Page 24
Page 24
The Passionate Society : The Social, Political and Moral Thought of Adam Ferguson
Adam Ferguson (1723-1816) was a major figure of the Scottish Enlightenment whose thought was, in many respects, original and distinctive. This book is a study of his ideas and of the intellectual forces that shaped them.Though somewhat overlooked in the nineteenth century, Ferguson was rescued from obscurity in the first half of the twentieth century by scholars interested in the origins of sociology and early critiques of modernity. Ferguson’s interest in the mechanics of social life and especially social change led him to many groundbreaking insights. In fact, he is sometimes identified as the 'Father of Modern Sociology'.
The Paraoxonases : Their Role in Disease Development and Xenobiotic Metabolism
Research into the paraoxonase (PON) multigene family has really only blossomed in the last 10 years. Before this time only PON1 was known and research was restricted to toxicologists investigating the metabolism of organophosphate insecticides and nerve gases and a few “mad” scientists searching for “natural” substrates. Since this time two new members PON2 and PON3 have been discovered, all 3 PONs have been shown to act as antioxidants and the PON family has taken centre stage as major players in the development of a wide variety of diseases such as cardiovascular disease, diabetes mellitus, rheumatism, Alzheimer and many more while remaining important in determining organophosphate toxicity.
The Papillomaviruses
This volume reviews the remarkable confluence of science, medicine, and public health that recently culminated in the approval of vaccines that prevent many human papillomavirus infections, the first vaccines specifically designed to prevent human cancer. Basic laboratory studies of viral DNA replication, gene expression, protein function, and virus-host interactions have provided fundamental insights into these important processes.
The Pangenome: Diversity, Dynamics and Evolution of Genomes
The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded.
The Palgrave Handbook of Twentieth and Twenty-First Century Literature and Science
Illustrates the evolution of literature and science, in collaboration and contestation, across the twentieth and twenty-first centuries. The essays it gathers question the charged rhetoric that pits science against the humanities while also demonstrating the ways in which the convergence of literary and scientific approaches strengthens cultural analyses of colonialism, race, sex, labor, state formation, and environmental destruction.
The Palgrave Handbook of Critical Menstruation Studies
This handbook, the first of its kind, provides a comprehensive and carefully curated multidisciplinary genre-spanning view of the state of the field of Critical Menstruation Studies, opening up new directions in research and advocacy. It is animated by the central question: ‘“what new lines of inquiry are possible when we center our attention on menstrual health and politics across the life course?” The chapters—diverse in content, form and perspective—establish Critical Menstruation Studies as a potent lens that reveals, complicates and unpacks inequalities across biological, social, cultural and historical dimensions.
The Palgrave handbook of applied ethics and the criminal law
Consists of essays on contemporary issues in criminal law and their theoretical underpinnings. Some of the essays deal with the relationship between morality and criminalization. Others deal with criminalization in the context of specific crimes such as fraud, blackmail, and revenge pornography. The contributors also address questions of responsible agency such as the effects of addiction or insanity, and some deal with punishment, its mode and severity, and the justness of the state's imposition of it. These chapters are authored by some of the most distinguished scholars in the fields of applied ethics, criminal law, and jurisprudence
The Painlevé Handbook
This book introduces the reader to methods allowing one to build explicit solutions to these equations. A prerequisite task is to investigate whether the chances of success are high or low, and this can be achieved without any a priori knowledge of the solutions, with a powerful algorithm presented in detail called the Painlevé test. If the equation under study passes the Painlevé test, the equation is presumed integrable. If on the contrary the test fails, the system is nonintegrable or even chaotic, but it may still be possible to find solutions.
The Pain Management Workbook : Powerful CBT and Mindfulness Skills to Take Control of Pain and Reclaim Your Life
You'll find a comprehensive outline of this effective biopsychosocial approach, as well as scientifically supported interventions rooted in cognitive- behavioral therapy (CBT), mindfulness, and neuroscience to help you take control of your pain--and your life! You'll learn strategies for creating a pain plan for home and work, reducing reliance on medications, and breaking the pain cycle. Also included are tips for improving sleep, nutrition for pain, methods for resuming valued activities, and more.
The p53 Tumor Suppressor Pathway and Cancer
The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging ?eld ?rst considered p53 as a viral antigen and then as an oncogene that cooperates with activated ras in transforming primary cells in culture. Fueling the concept of p53 acting as a transforming factor, p53 expression was markedly elevated in various transformed and tumorigenic cell lines when compared to normal cells. In a simple twist of fate, most of the studies conducted in those early years inadvertently relied on a point mutant of p53 that had been cloned from a normal mouse genomic library. A bona ?de wild-type p53 cDNA was subsequently isolated, ironically, from a mouse teratocarcinoma cell line. A decade after its discovery, p53 was shown to be a tumor suppressor that protects against cancer. It is now recognized that approximately half of all human tumors arise due to mutations within the p53 gene. As remarkable as this number may seem, it signil cantly underrepresents how often the p53 pathway is targeted during tumorigenesis. It is my personal view, as well as many in the p53 ?eld, that the p53-signaling pathway is corrupted in nearly 100% of tumors. If you are interested in understanding cancer and how it develops, you must begin by studying p53 and its pathway. After demonstrating that p53 functions as a tumor suppressor the ?eld exploded and p53 became a major focus of scientists around the world.
The Oxford handbook of law and politics
This book gathers together leading scholars in the field to assess key literatures shaping the discipline today and to help set the direction of research in the decade ahead. The study of law and politics is one of the foundation stones of the discipline of political science, and it has been one of the most productive areas of cross-fertilization between the various subfields of political science and between political science and other cognate disciplines.
The ortho-perio patient : Clinical evidence & therapeutic guidelines
Provides a broad analysis of the topic from both the periodontal and orthodontic perspectives. The authors systematically analyze the scientific and clinical interactions of these specialties by reviewing all the available evidence and using case studies to demonstrate the principles discussed in theory. The result is a text that outlines the treatment fundamentals and shows how to improve the therapeutic outcomes involving orthodontic-periodontic interventions.
The Origins of Language : Unraveling Evolutionary Forces
Developments in cognitive science indicate that human and nonhuman primates share a range of behavioral and physiological characteristics that speak to the issue of language origins. This volume has three major themes, woven throughout the chapters. First, it is argued that scientists in animal behavior and anthropology need to move beyond theoretical debate to a more empirically focused and comparative approach to language. Second, those empirical and comparative methods are described, revealing underpinnings of language, some of which are shared by humans and other primates and others of which are unique to humans. New insights are discussed, and several hypotheses emerge concerning the evolutionary forces that led to the "design" of language. Third, evolutionary challenges that led to adaptive changes in communication over time are considered with an eye toward understanding various constraints that channeled the process.
The Organized Crime Community : Essays in Honor of Alan A. Block
In his social investigative writings on "the serious crime community" which describes the loose merger of corporate interests, organized crime and political crime, professor Alan A. Block of Penn State University has proven to be one of the most inspiring criminologists in the field. An international group of pupils and friends dedicate this book to him which contains original contributions on the troubled concept of organized crime, the social history of crime groups in the United States, corruption in the United Nations Oil-for-Food Program in Iraq, the struggle against identity fraud, the world of drugs and the adverse consequences of criminalization, the money-laundering control movement, International Tribunals against war crimes and a Jewish studies chapter on the role of bystanders during the Holocaust.
The Onlife Manifesto : Being Human in a Hyperconnected Era
What is the impact of information and communication technologies (ICTs) on the human condition? In order to address this question, in 2012 the European Commission organized a research project entitled The Onlife Initiative: concept reengineering for rethinking societal concerns in the digital transition. This volume collects the work of the Onlife Initiative. It explores how the development and widespread use of ICTs have a radical impact on the human condition. ICTs are not mere tools but rather social forces that are increasingly affecting our self-conception (who we are), our mutual interactions (how we socialise); our conception of reality (our metaphysics); and our interactions with reality (our agency).
The olfactory system
Cover topics such as techniques for manipulating and measuring olfactory cilia function; approaches for investigating spatial RNA expression in olfactory mucosa; the use of chromatin immunoprecipitation with olfactory neurons; in vivo methods to label and identify activated olfactory neurons; defining organization in the olfactory bulbs and cortex; and the use of optical recording in the mouse olfactory bulb for acute or chronic experiments.
The NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis, and Cancer
Recent research indicates that the immune system and inflammatory reactions are governed and regulated by powerful neuronal mediators derived from the central and peripheral nervous system. The NPY family of peptides is a diverse group of neuropeptides that acts via multiple receptors, Y1-Y5, which are widespread not only in neurons but also in a variety of non-neural and immune cells. These peptides have been known as important regulators of many essential systems, such as blood pressure and cardiac function, food consumption and energy homeostasis. However, in recent years, they have also become recognized for their role as potent modulators of cell growth and immune functions with broad implications in chronic inflammatory diseases, cancer and angiogenesis. In this book, experts in the field analyze recent evidence supporting the role of NPY family of peptides in regulation of the immune/inflammatory system with special reference to its medical and therapeutic implications.
The Nidoviruses : Toward Control of SARS and other Nidovirus Diseases
Based on the 10th International Nidovirus Symposium: Towards Control of SARS and other Nidovirus Diseases, this book includes articles by major contributors to this area of research. It covers such topics as RNA synthesis; protein synthesis, structure and processing; viral assembly and release; pathogenesis of non-human coronaviruses; and more.
The Next Wave in Computing, Optimization, and Decision Technologies
The first section contains two papers on network models. The second section focuses in integer and mixed integer programming. The third section contains papers in which heuristic search and metaheuristics are applied. Three papers using stochastic modeling comprise the fourth section. In the fifth section, the unifying theme is software and modeling. The sixth section contains four papers on classification, clustering, and ranking. Each article in the volume has been carefully reviewed and revised accordingly. Computer Science and Operations Research continue to have a synergistic relationship and this book represents the results of the cross-fertilization between OR/MS and CS/AI. It is this interface of OR/CS that makes possible advances that could not have been achieved in isolation. Taken collectively, these articles are indicative of the state-of-the-art in the interface between OR/MS and CS/AI and of the high-caliber research being conducted by members of the INFORMS Computing Society.
The New Worlds: Extrasolar Planets
Exoplanet, extrasolar planet, exoEarth, exojupiter: neologisms still absent from many dictionaries. These terms are, however, current among astronomers, and are heard in their answers to a question already two millennia old: are there planets like ours elsewhere in the Universe? Greek atomists such as Epicurus were convinced of the existence of an infinite number of solar systems like our own, but it was only in 1995 that a real answer began to emerge.
