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Introduction to Classical Geometries
This book follows Felix Klein’s proposal of studying geometry by looking at the symmetries (or rigid motions) of the space in question. In this way the classical geometries are studied: Euclidean, affine, elliptic, projective and hyperbolic. For simplicity the focus is on the two-dimensional case, which is already rich enough, though some aspects of the 3- or n-dimensional geometries are included. Once plane geometry is well understood, it is much easier to go into higher dimensions.
Introduction to biologic and biosimilar product development and analysis
Gives a concise introduction to development and analysis of pharmaceutical biologics for those in the pharmaceutical industry who are switching focus from small molecules to biologics processing, analysis, and delivery. In order to maintain a limited focus, Introduction to Biologic and Biosimilar Product Development and Analysis, will deal only with peptides, proteins and monoclonal antibodies.
Introduction to Bayesian Statistics
This is the second and translated edition of the German book “Einf ̈uhrung in die Bayes-Statistik, Springer-Verlag, Berlin Heidelberg New York, 2000”. It has been completely revised and numerous new developments are pointed out together with the relevant literature. The Chapter 5.2.4 is extended by the stochastic trace estimation for variance components. The new Chapter 5.2.6 presents the estimation of the regularization parameter of type Tykhonov regularization for inverse problems as the ratio of two variance components.The reconstruction and the smoothing of digital three-dimensional images is demonstrated in the new Chapter 5.3. The Chapter 6.2.1 on importance sampling for the Monte Carlo integration is rewritten to solve a more general integral. This chapter contains also the derivation of the SIR (sampling-importance-resampling) algorithm as an alternative to the rejection method for generating random samples. Markov Chain Monte Carlo methods are now frequently applied in Bayesian statistics.
Introduction to basics of pharmacology and toxicology ; Vol.3 : Experimental pharmacology : Research methodology and biostatistics
Elaborates on the general principles of experimental pharmacology. Describes about the screening methods for the evaluation of different categories of drugs. Summarizes the various aspects of research methodology and biostatistics.
Introduction to basics of pharmacology and toxicology ; Vol.2 : Essentials of systemic pharmacology : From principles to practice
Describes the pharmacology of drugs acting on different systems in the human body Analyses various human diseases and the pharmacological agents governing them Provides a valuable reference resource for academicians, researchers, and clinical practitioners Offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics.
Introduction to basics of pharmacology and toxicology ; Vol.1 : General and molecular pharmacology : Principles of drug action
Illustrates the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases.
Introduction aux méthodes numériques
Au cours de l’histoire, les méthodes de calcul ont été l’expression de pratiques sans cesse renouvelées. Le développement de l’informatique a largement contribué à une rapide progression de l’ensemble des techniques numériques. En moins de cinquante ans, le paysage algorithmique a été complètement transformé. Aujourd’hui, la plupart des logiciels que nous employons font appel à des méthodes de plus en plus efficaces. Dans les simulations, comme dans les modélisations, l’analyse numérique occupe une place centrale. Composants essentiels de la vie scientifique, les méthodes et algorithmes qui sont présentés ici, illustrés par de nombreux exemples, sont mis à la portée de tous. De l’approximation polynomiale à la résolution d’équations aux dérivées partielles par des méthodes de différences, de volumes et d’éléments finis, ce livre offre un large panorama des méthodes numériques actuelles.
Introducing Blockchain with Java : Program, Implement, and Extend Blockchains with Java
Includes numerous exercises and test questions to help you solidify what you have learned as you progress through the book, and provides ideas on expanding the codebase to make it your own. You will have access to a fully-functioning repository with Java code. You will have the knowledge necessary to program your own blockchains with Java and you will have a completed project for your portfolio. You will: Know the most important theoretical concepts of the blockchain / Code the blockchain in Java / Create a user interface with JavaFX / Implement SQLite DB using JDBC Driver / Create a P2P multi-threaded app / Create your own cryptocurrency app with full functionality / Implement blockchain technology on a P2P network from scratch using Java, JavaFX, and SQL
Intrinsic Molecular Mobility and Toughness of Polymers II
The series Advances in Polymer Science presents critical reviews of the present and future trends in polymer and biopolymer science including chemistry, physical chemistry, physics and material science . the authors highlight the dual role of segmental jumps and displacements to improve toughness by energy dissipation and relaxation of critical stresses and to influence without exception all damage mechanisms. The dynamic response of a chain segment to thermo-mechanical excitation strongly depends on in-chain cooperative motions. By combining the powerful techniques of multi-dimensional Nuclear Magnetic Resonance and of dielectric and dynamic mechanical analysis Monnerie,
Intrinsic Molecular Mobility and Toughness of Polymers I
The series Advances in Polymer Science presents critical reviews of the present and future trends in polymer and biopolymer science including chemistry, physical chemistry, physics and material science . the authors highlight the dual role of segmental jumps and displacements to improve toughness by energy dissipation and relaxation of critical stresses and to influence without exception all damage mechanisms. The dynamic response of a chain segment to thermo-mechanical excitation strongly depends on in-chain cooperative motions. By combining the powerful techniques of multi-dimensional Nuclear Magnetic Resonance and of dielectric and dynamic mechanical analysis Monnerie,
Intraseasonal Variability in the Atmosphere-Ocean Climate System
As the first comprehensive and authoritative review of intra-seasonal variability (ISV), this multi-author work balances coverage of observation, theory and modeling and provides a single source of reference for all those interested in this important, multi-faceted natural phenomenon and its relation to major short-term climatic variations. Commencing with an overview of ISV and observations from an historical perspective, the book offers successive chapters that deal with the role of ISV in monsoon variability on the monsoon regions of South Asia, East Asia and South America, in North America, and in the oceans. The coupling between ocean and atmosphere is considered, together with the function of angular momentum and Earth rotation.
Intraoperative complications in dental implants
Examines intraoperative complications associated with dental implant surgery, a critical and under-researched area in dental practice. The study focuses on identifying the most common intraoperative complications, their potential causes, and dental surgeons' strategies to manage these issues effectively. Through a comprehensive review of recent literature and a series of case studies, this research identifies specific risk factors and procedural challenges that lead to complications during the surgical phase of implant placement. Additionally, the thesis proposes a set of guidelines aimed at minimizing the occurrence of these complications.
Intramembrane-Cleaving Proteases (I-CLiPs)
The aim of this book is to provide an update on this emerging group of unusual but important proteases for both the specialist and those with a broader interest in proteases. Amongst the target audience will be protease researchers, enzymologists, those working in academia and the pharmaceutical industry on biological processes and diseases involving I-CLiPs.
Intracellular Mechanisms for Neuritogenesis
This book present in novel, distinct, but highly related aspects of the intracellular mechanisms required for the formation of a functional neurite, which include cytoskeletal organization, membrane traffic, and signal transduction.
Intertwingled : The work and influence of Ted Nelson
This engaging volume celebrates the life and work of Theodor Holm “Ted” Nelson, a pioneer and legendary figure from the history of early computing. Presenting contributions from world-renowned computer scientists and figures from the media industry, the book delves into hypertext, the docuverse, Xanadu, and other products of Ted Nelson’s unique mind.
Interstitial fibrosis in heart failure
Interstitial Fibrosis in Heart Failure, edited by Francisco J. Villarreal, M.D., Ph.D., provides a timely and integrative review of the basics of cardiac extracellular matrix structure. Topics covered include how cardiac remodeling influences its disposition, abundance and function; possible non-invasive techniques for diagnosis; and potential drug-based or molecular therapeutic strategies that may interrupt or even reverse the course of the development of cardiac fibrosis. This resource for both clinicians and scientists aims to cover state-of-the-art findings relevant to cellular and molecular processes underlying cardiac fibrosis including basic elements of structure, function, diagnosis and treatment.
Intersections de deux quadriques et pinceaux de courbes de genre 1 = Intersections of two quadrics and pencils of curves of genus 1
This research monograph focuses on the arithmetic, over number fields, of surfaces fibred into curves of genus 1 over the projective line, and of intersections of two quadrics in projective space. The first half contains a complete account of the technique initiated by Swinnerton-Dyer in 1993 for studying rational points on pencils of curves of genus 1, while incorporating and generalising most of its subsequent refinements. The second half, which builds upon the first, is devoted to quartic del Pezzo surfaces and higher-dimensional intersections of two quadrics.
Interplanetary Mission Analysis and Design
The book describes current mission analysis and design techniques that may be applied to a very wide range of interplanetary missions from those targeting the inner planets to those destined for the outer planets and Solar System escape trajectories.
Interphases and Mesophases in Polymer Crystallization I
Polyethylene forms a two-dimensional hexagonal phase, stable at 3 GPa depending on molecular length, which in recent years has been claimed to intervene in crystallization prior to the formation of the usual orthorhombic phase even at atmospheric pressure. This claim is evaluated and shown to be without substance. There is very little evidence that the theoretical possibility of thin lamellae being more stable in the hexagonal phase than the orthorhombic at atmospheric pressure, if the former has sufficiently low fold surface free energy, does occur in practice. But the existence of single crystals of the orthorhombic phase unambiguously shows that they did not have a hexagonal precursor; that would have made them threefold twins. The overwhelming mass of evidence is that orthorhombic and hexagonal phases crystallize independently in accordance with the phase diagram and kinetic competition during growth, as has been understood since the hexagonal phase was discovered.
Interorganisational Standards : Managing Web Services Specifications for Flexible Supply Chains
Standards play crucial roles in many different aspects of today’s economy. They can define meanings of semantics, product interfaces, process steps, or performance levels. Interorganisational standards are specifications that define business-related semantics and processes, which are made accessible to other organisations’ information systems. While modular organisation forms such as supply chain networks demand such standards for higher flexibility, XML-based Web Services offer a relatively new technological platform to develop such standards.
