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A short guide to clinical pharmacokinetics
Consists of seven chapters that cover various aspects of pharmacokinetics and its clinical applications. The chapters are structured to provide clear objectives and keywords are bolded throughout the text to facilitate understanding. The topics covered include the significance of pharmacokinetics in clinical practice, factors affecting pharmacokinetic parameters, pharmacokinetic drug interactions, therapeutic drug monitoring, dosage adjustment in different population groups, the influence of hepatic diseases on pharmacokinetics and the impact of pharmacogenomics on pharmacokinetics and pharmacodynamics.
A Roadmap for Formal Property Verification
Develops the answers to these questions and fits them into a roadmap for formal property verification – a roadmap that shows how to glue FPV technology into the traditional validation flow. A Roadmap for Formal Property Verification explores the key issues in this powerful technology through simple examples – you do not need any background on formal methods to read most parts of this book.
A Risk-Benefit Perspective on Early Customer Integration
Customer integration in the early innovation phase has been considered the method of choice in theory and practice. Growing experience with the concept has shown unexpected side effects that may even outweigh its recognized advantages. Therefore, management needs to be able to assess in advance whether the involvement of customers will add overall value to each particular innovation project. To support but not to replace the final managerial decision, a mathematical formula is developed. It can be applied to all kinds of process structures, takes into account the risks and benefits contingent on a company's situation as well as risk-reducing and benefit-increasing measures and translates them into numerical values. The resulting figure indicates the prospective value of customer integration in a specific project.
A Remarkable Collection of Babylonian Mathematical Texts : Manuscripts in the Schøyen Collection: Cuneiform Texts I
This new text from Jöran Friberg, the leading expert on Babylonian mathematics, presents 130 previously unpublished mathematical clay tablets from the Norwegian Schøyen collection, and provides a synthesis of the author's most important work. Through a close study of these tablets, Friberg has made numerous amazing discoveries, including the first known examples of pre-Classical labyrinths and mazes, a new understanding of the famous table text Plimpton 322, and new evidence of Babylonian familiarity with sophisticated mathematical ideas and objects, such as the three-dimensional Pythagorean equation and the icosahedron.
A Reappraisal of the Ascending Systems in Man, with Emphasis on the Medial Lemniscus
Based on material assembled by Dr Jaap HR Schoen who was one of the few neuroanatomists to apply the Nauta method to human material. Gaining insight in the consequences of longitudinal damage to the human spinal cord is necessary before reimplantation of the avulsed rootlets or an autologous transplant can be performed in man.
A primer on theoretical soil mechanics
A Primer to Theoretical Soil Mechanics is about adapting continuum mechanics to granular materials. The field of continuum mechanics offers many fruitful concepts and methods, however there is declining interest in the field due to its complex and fragmented nature. This book's purpose is therefore to facilitate the understanding of the theoretical principles of soil mechanics, as well as introducing the new theory of barodesy.
A Primer for the Exercise and Nutrition Sciences : Thermodynamics, Bioenergetics, Metabolism
Provides a fresh approach to the study of energy expenditure by introducing the latest concepts in open system thermodynamics and cellular to whole-body energy exchange. A journey is undertaken by the reader, beginning with what energy is and where the energy in glucose is found, and ending with the concept of high versus low intensity exercise in augmenting weight loss.
A Primal Perspective on the Philosophy of Religion
This book challenges this widespread assumption and demonstrates how primal religions have something significant to offer on virtually every theme discussed in the philosophy of religion. Through this book the primal religous tradition stakes its claim for a place at the table.Despite the absence of written texts, primal religions have an implicit philosophy.This study shows how materials of primal religious experience can be incorporated in the categories of modern philosophy of religion. The book contends that the primal perspective can widen and deepen the horizons of philosophy of religion and enhance the philosophical appreciation of religion as a universal phenomenon.
A Practical Guide to Lightcurve Photometry and Analysis
A Practical Guide to Lightcurve Photometry and Analysis provides, for those with access to even a modest telescope and CCD camera, all the information needed to take part in the scientific study of asteroids and variable stars.A Practical Guide to Lightcurve Photometry and Analysis contains all the material needed for readers to understand the theory, and avoid the practical pitfalls of lightcurve photometry. Detailed examples are given for obtaining data, and of course for the exciting and rewarding task of analyzing the data to determine the physical properties of the object.
A Pocket Guide to Epidemiology
A Pocket Guide to Epidemiology is a useful addition to the ready reference genre of epidemiological texts. … The text offers a comprehensive look at the salient fundamentals of epidemiology. … Organized logically and replete with classic examples, the text offers a firm foundation in epidemiological methodology. … this guide offers more examples and may be a better choice for the reader who desires to become better acquainted with epidemiology.
A Platform-Centric Approach to System-on-Chip (SOC) Design
The book proposes a new methodology for realizing platform-centric design of complex systems, and presents a detailed plan for its implementation. The proposed plan allows component vendors, system integrators and product developers to collaborate effectively and efficiently to create complex products within budget and schedule constraints.
A Multidisciplinary Approach to Capability in Age and Ageing
This book provides insight on how to interpret capability in ageing – one’s individual ability to perform actions in order to reach goals one has reason to value – from a multidisciplinary approach. the book describes this demographic trends as well as the large global challenges and important societal implications this will have such as a worldwide increase in the number of persons affected with dementia, and in the ratio of retired persons to those still in the labor market. Through contributions from many different research areas, it discussed how capability depends on interactions between the individual (e.g. health, genetics, personality, intellectual capacity), environment (e.g. family, friends, home, work place), and society (e.g. political decisions, ageism, historical period).
A Modern Theory of Factorial Design
Factorial design plays a fundamental role in efficient and economic experimentation with multiple input variables and is extremely popular in various fields of application, including engineering, agriculture, medicine and life sciences. Factorial experiments are often used in case studies in quality management and Design for Six Sigma (DFSS).Factorial design plays a fundamental role in efficient and economic experimentation with multiple input variables and is extremely popular in various fields of application, including engineering, agriculture, medicine and life sciences. Factorial experiments are often used in case studies in quality management and Design for Six Sigma (DFSS).
A Modern Introduction to Probability and Statistics : Understanding Why and How
A Modern Introduction to Probability and Statistics has numerous quick exercises to give direct feedback to the students. In addition the book contains over 350 exercises, half of which have answers, of which half have full solutions. A website at www.springeronline.com/1-85233-896-2 gives access to the data files used in the text, and, for instructors, the remaining solutions. The only pre-requisite for the book is a first course in calculus; the text covers standard statistics and probability material, and develops beyond traditional parametric models to the Poisson process, and on to useful modern methods such as the bootstrap.
A Modern Course in Aeroelasticity
In this new edition, the fundamental material on classical linear aeroelasticity has been revised. Also new material has been added describing recent results on the research frontiers dealing with nonlinear aeroelasticity as well as major advances in the modelling of unsteady aerodynamic flows using the methods of computational fluid dynamics and reduced order modeling techniques.
A Mathematical Introduction to Conformal Field Theory
The first part of this book gives a detailed, self-contained and mathematically rigorous exposition of classical conformal symmetry in n dimensions and its quantization in two dimensions. In particular, the conformal groups are determined and the appearance of the Virasoro algebra in the context of the quantization of two-dimensional conformal symmetry is explained via the classification of central extensions of Lie algebras and groups. The second part surveys some more advanced topics of conformal field theory, such as the representation theory of the Virasoro algebra, conformal symmetry within string theory, an axiomatic approach to Euclidean conformally covariant quantum field theory and a mathematical interpretation of the Verlinde formula in the context of moduli spaces of holomorphic vector bundles on a Riemann surface.
A Logical Approach to Philosophy : Essays in Honour of Graham Solomon
The papers in this collection are united by an approach to philosophy. They illustrate the manifold contributions that logic makes to philosophical progress, both by the application of formal methods to traditional philosophical problems and by opening up new avenues of inquiry as philosophers sort out the implications of new and often surprising technical results. Contributions include new technical results rich with philosophical significance for contemporary metaphysics, attempts to diagnose the philosophical significance of some recent technical results, philosophically motivated proposals for new approaches to negation, investigations in the history and philosophy of logic, and contributions to epistemology and philosophy of science that make essential use of logical techniques and results.
A life cycle for clusters? : The dynamics of agglomeration, change, and adaption
The phenomenon of non-random spatial concentrations of firms in one or few related sectors (clusters) is intensively debated in economic theory and policy. The euphoria about successful clusters however neglects that historically, many thriving clusters did deteriorate into old industrial areas. This book studies the determinants of cluster survival by analyzing their adaptability to change in the economic environment. Linking theoretic knowledge with empirical observations, a simulation model (based in the N/K method) is developed, which explains when and why the cluster's architecture assists or hampers adaptability. It is found that architectures with intermediate degrees of division of labour and more collective governance forms foster adaptability. Cluster development is thus path dependent as architectures having evolved over time impact on the likelihood of future survival.
A Language of Contemporary Architecture : An Index of Topology and Typology
Provides an index of ideas, theories, projects, and definitions that string into a methodology for evaluating the contemporary language of architecture described as “contemporism” through a review of topology (form) and typology (system and elements). Trying to answer the postmodern question of how to move beyond modernism through a thread of architectural styles that tried to respond to deficiencies from the modern promise and contextual changes. Yet, the question remains, should this ongoing struggle to move beyond modernism be a stylistic battle? Has the present architectural practice ever left the modernist tendencies, and is there a structure for a contemporary language in architecture?. Presents a collection of highly illustrated projects that have worked under these parameters to break away from modernism in order to present a holistic integration of topology and typology as a language for “contemporism.” The index is illustrated with individual spreads, which can be read sequentially or independently, and encourages the reader to make their own connections. It also includes interviews and contributions from Toyo Ito, Anthony Vidler, Ben van Berkel, Christian Kerez, and Greg Lynn.
A History of Plastic Surgery
Te frst section deals with anatomy and the healing of wounds, discusses You have in your hands a work that should become a old and new plastic surgical procedures, and outlines the milestone of our understanding of medical history. In it history of anaesthesia. Te second covers the methods Professor Paolo Santoni-Rugiu and Mr Philip Sykes trace used from ancient times to reconstruct various areas of the development of plastic surgery and much of medi- the body and is the most extensive. Te last section d- cine in general, over three millennia. With his extensive cusses the history of cosmetic surgery and the origin of knowledge of clinical plastic surgery, no one could be present day procedures. better placed than the senior author to gather this valu- Te pages ring with the names of giants of the medical able material from historical documents.
