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Genome instability in cancer development
Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These important findings not only explain the occurrence of certain hereditary tumours, but they also set the stage for the development of anti-cancer drugs that specifically target activated oncogenes.
Génetique statistique = Statistical genetics
Presents the main statistical tools useful in genetics: significance tests, analysis methods based on the likelihood function, EM algorithm, modeling, analysis of variance, hierarchical classifications, multiple comparisons, etc. All of them shed light on a number of biological phenomena such as carcinogenesis, population genetics, Hardy-Weinberg equilibrium, natural selection, mutations, heredity, coalescence processes, and even evolution. This book is intended for mathematicians and biologists alike. Written with a great concern for clarity, it is also accessible to non-specialists who will be able, thanks to it, to strengthen their theoretical base and above all to develop their know-how through very concrete applications.
Genetic algorithms: theory, design and programming
We present a series of scientific contributions that delve into the intricate theoretical foundations and practical nuances of genetic algorithms (GAs). Beyond the academic realm, GAs have demonstrated profound applications in societal decision-making and engineering optimization, showcased through real-world examples and case studies. A dedicated section on programming principles offers a thorough guide for implementing GAs across diverse languages. This edition, tailored for researchers and academics, serves as a testament to the scientific advancements within the field, inviting readers to explore the nuanced journey from theoretical constructs to pragmatic applications in the dynamic landscape of GAs.
Generalized Convexity, Generalized Monotonicity and Applications ; Proceedings of the 7th International Symposium on Generalized Convexity and Generalized Monotonicity
This volume contains a collection of refereed articles on generalized convexity and generalized monotonicity. The first part of the book contains invited papers with applications of (generalized) convexity to such diverse fields as algebraic dynamics of the Gamma function values, discrete optimization, Lipschitzian stability of parametric constraint systems, and monotonicity of functions. The second part contains contributions presenting the latest developments in generalized convexity and generalized monotonicity: its connections with discrete and with continuous optimization, multiobjective optimization, fractional programming, nonsmooth Aanalysis, variational inequalities, and its applications to concrete problems such as finding equilibrium prices in mathematical economics, or hydrothermal scheduling.
Generalized collocations methods : Solutions to nonlinear problems
This book examines various mathematical tools—based on generalized collocation methods—to solve nonlinear problems related to partial differential and integro-differential equations. Covered are specific problems and models related to vehicular traffic flow, population dynamics, wave phenomena, heat convection and diffusion, transport phenomena, and pollution. Based on a unified approach combining modeling, mathematical methods, and scientific computation, each chapter begins with several examples and problems solved by computational methods; full details of the solution techniques used are given. The last section of each chapter provides problems and exercises giving readers the opportunity to practice using the mathematical tools already presented.
General Relativity
This book offers an alternative to other textbooks on the subject, providing a more specific discussion of numerous general relativistic effects for readers who have knowledge of classical mechanics and electrodynamics, including special relativity. Coverage includes gravitational lensing, signal retardation in the gravitational field of the Sun, the Reissner-Nordström solution, selected spin effects, the resonance transformation of an electromagnetic wave into a gravitational one, and the entropy and temperature of black holes. The book includes numerous problems at various levels of difficulty, making it ideal also for independent study by a broad readership of advanced students and researchers.
Gastrointestinal malignancies
Details the advances in drug discovery and delivery and the present need for emerging technologies. Throughout the text new micro and nanofabrication techniques are described, including methods such as electrohydrodynamic processes, additive manufacturing, and microfluidics, which have the potential to produce drug delivery systems that were not possible a few years ago. This book is of great use to both entry-level and experienced researchers in the field of emerging technologies for the manufacturing of drug delivery devices.
Gas Transport in Porous Media
This book presents a compilation of state-of-the art studies on gas and vapor transport processes in porous and fractured media. A broad set of models and processes is presented, including advection/diffusion, the Dusty Gas Model, enhanced vapor diffusion, phase change, coupled processes, solid/vapor sorption, and vapor-pressure lowering. Numerous applications are also presented that illustrate these processes and models in current problems facing the scientific community.
Gas Cyclones and Swirl Tubes : Principles, Design, and Operation
These are cyclones used as gas-solid separators for dedusting and as gas-liquid separators for demisting, and as such they are widely used in industry. The optimization of cyclone performance for any given task is an often-sought goal but is seldom achieved in practice. Understanding cyclone performance as a function of a cyclone's size, geometry, feed properties, feed flow rates and the system of which it is a part, is essential if one wishes to successfully design, operate, troubleshoot or predict cyclone performance.
Game Theory : Decisions, Interaction and Evolution
This introduction to game theory is written from a mathematical perspective. Its primary purpose is to be a first course for undergraduate students of mathematics, but it also contains material which will be of interest to advanced students or researchers in biology and economics.An understanding of basic calculus and probability is assumed but no prior knowledge of game theory is required. Detailed solutions are provided for the numerous exercises.
Galling Arthropods and Their Associates ; Ecology and Evolution
The book addresses recent developments in the ecology, evolution, systematics, physiology, and biodiversity of gall-inducing arthropods, with individual contri butions ranging in scope from detailed descriptions to profoundly synthetic stud ies. One underlying theme of the book is the various impacts of gall induction that indirectly affect insect communities on the host plant. The other important contri bution is the highly intricate and dynamic interactions between galling arthropods and their uniquely specialized host plants. Included also are chapters that discuss biodiversity and distribution patterns of gall-inducing arthropods, and biological control of invasive gall-inducing arthropods and of invasive trees. We believe that this book makes an important contribution to the knowledge of galling arthropods and their associates and to the development of robust, general principles of the ecology and evolution of these organisms.
Fuzzy systems and knowledge discovery ; Vol. 4223 ; Third International Conference, FSKD 2006, Xi'an, China, September 24-28, 2006, Proceedings
ICNC-FSKD 2006 featured the most up-to-date research results in com- tational algorithms inspired from nature, including biological, ecological, and physical systems. It is an exciting and emerging interdisciplinary area in which a wide rangeof techniques and methods arebeing studied for dealing with large, complex, and dynamic problems.
Fuzzy systems and knowledge discovery ; Vol. 3614 ; 2nd International Conference, FSKD 2005, Changsha, China, August 27-29, 2005, Proceedings, Part II
This book and its sister volume, LNAI 3613 and 3614, constitute the proce- ings of the Second International Conference on Fuzzy Systems and Knowledge Discovery (FSKD 2005), jointly held with the First International Conference on Natural Computation (ICNC 2005, LNCS 3610, 3611, and 3612) from - gust 27–29, 2005 in Changsha, Hunan, China. FSKD 2005 successfully attracted 1249 submissions from 32 countries/regions (the joint ICNC-FSKD 2005 received 3136 submissions). After rigorous reviews, 333 high-quality papers, i. e. , 206 long papers and 127 short papers, were included in the FSKD 2005 proceedings, r- resenting an acceptance rate of 26. 7%. The ICNC-FSKD 2005 conference featured the most up-to-date research - sults in computational algorithms inspired from nature, including biological, e- logical, and physical systems. It is an exciting and emerging interdisciplinary area in which a wide range of techniques and methods are being studied for dealing with large, complex, and dynamic problems. The joint conferences also promoted cross-fertilization over these exciting and yet closely-related areas, which had a signi?cant impact on the advancement of these important technologies. Speci?c areas included computation with words, fuzzy computation, granular com- tation, neural computation, quantum computation, evolutionary computation, DNA computation, chemical computation, information processing in cells and tissues, molecular computation, arti?cial life, swarm intelligence, ants colony, arti?cial immune systems, etc. , with innovative applications to knowledge d- covery, ?nance, operations research, and more.
Fuzzy systems and knowledge discovery ; Vol. 3613 ; 2nd International Conference, FSKD 2005, Changsha, China, August 27-29, 2005, Proceedings, Part I
This book and its sister volume, LNAI 3613 and 3614, constitute the proce- ings of the Second International Conference on Fuzzy Systems and Knowledge Discovery (FSKD 2005), jointly held with the First International Conference on Natural Computation (ICNC 2005, LNCS 3610, 3611, and 3612) from - gust 27–29, 2005 in Changsha, Hunan, China. FSKD 2005 successfully attracted 1249 submissions from 32 countries/regions (the joint ICNC-FSKD 2005 received 3136 submissions). After rigorous reviews, 333 high-quality papers, i. e. , 206 long papers and 127 short papers, were included in the FSKD 2005 proceedings, r- resenting an acceptance rate of 26. 7%. The ICNC-FSKD 2005 conference featured the most up-to-date research - sults in computational algorithms inspired from nature, including biological, e- logical, and physical systems. It is an exciting and emerging interdisciplinary area in which a wide range of techniques and methods are being studied for dealing with large, complex, and dynamic problems. The joint conferences also promoted cross-fertilization over these exciting and yet closely-related areas, which had a signi?cant impact on the advancement of these important technologies. Speci?c areas included computation with words, fuzzy computation, granular com- tation, neural computation, quantum computation, evolutionary computation, DNA computation, chemical computation, information processing in cells and tissues, molecular computation, arti?cial life, swarm intelligence, ants colony, arti?cial immune systems, etc. , with innovative applications to knowledge d- covery, ?nance, operations research, and more.
Fuzzy multi-criteria decision making : Theory and applications with recent developments
In trying to make a satisfactory decision when imprecise and multicriteria situations are involved, a decision maker has to use a fuzzy multicriteria decision making method. Fuzzy Multi-Criteria Decision Making (MCDM) presents fuzzy multiattribute and multiobjective decision-making methodologies by distinguished MCDM researchers. In summarizing the concepts and results of the most popular fuzzy multicriteria methods, using numerical examples, this work examines all the fuzzy multicriteria methods recently developed, such as fuzzy AHP, fuzzy TOPSIS, interactive fuzzy multiobjective stochastic linear programming, fuzzy multiobjective dynamic programming, grey fuzzy multiobjective optimization, fuzzy multiobjective geometric programming, and more.
Fuzzy Logic in Action : Applications in Epidemiology and Beyond
The volume addresses the most significant topics in the broad areas of epidemiology, mathematical modeling and uncertainty, embodying them within the framework of fuzzy set and dynamic systems theory.
Fuzzy Logic : A Spectrum of Theoretical & Practical Issues
This book exclusively surveys the active on-going research of the current maturity of fuzzy logic over the last four decades. Many world leaders of fuzzy logic have enthusiastically contributed their best research results into five theoretical, philosophical and fundamental sub areas and nine distinctive applications, including two PhD dissertations from two world class universities dealing with cutting-edge research areas of bioinformatics and geological science. Beyond the scope of survey and collection of the book, one important spin off is the emerging and recognition of a major scientific paradigm shift from the conventional mathematics to the mathematics of uncertainty, which arguably holds the key to solving very difficult and complex problems in biological and social sciences alike. The book, loaded with historical perspective, creative thinking, critical reviewing, and uniquely constructed strategy for future growth of this dynamic research area, is an invaluable resource for active researchers at all levels, university administrators, foundation directors, funding agency program chiefs, research & development planners and technological assessors.
Future tech : How to capture value from disruptive industry trends
In Future Tech, the author reveals that true change only results from combining the forces of science and technology, policy and regulation, new business models (i.e. sharing economy) and social dynamics (whether or not people adopt it). Whether these four forces align explains why some technologies, such as AI, blockchain, robotics, synthetic biology and 3D printing, stick and why others fail.
Future space-transport-system components under high thermal and mechanical loads : results from the DFG Collaborative Research Center TRR40
This book presents the findings of Collaborative Research Center Transregio 40 (TRR40), initiated in July 2008 and funded by the German Research Foundation (DFG). Gathering innovative design concepts for thrust chambers and nozzles, as well as cutting-edge methods of aft-body flow control and propulsion-component cooling, it brings together fundamental research undertaken at universities, testing carried out at the German Aerospace Center (DLR) and industrial developments from the ArianeGroup
Future Satellite Gravimetry and Earth Dynamics
Currently, a first generation of dedicated satellite missions for the precise mapping of the Earth’s gravity field is in orbit (CHAMP, GRACE, and soon GOCE). The gravity data from these satellite missions provide us with very new information on the dynamics of planet Earth. In particular, on the mass distribution in the Earth’s interior, the entire water cycle (ocean circulation, ice mass balance, continental water masses, and atmosphere), and on changes in the mass distribution. The results are fascinating, but still rough with respect to spatial and temporal resolution. Technical progress in satellite-to-satellite tracking and in gravity gradiometry will allow more detailed results in the future. In this special issue, Earth scientists develop visions of future applications based on follow-on high-precision satellite gravimetry missions.
