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Innovative Endocrinology of Cancer
Deals with developments in such topics as mechanisms of hormonal carcinogenesis, epidemiology and risk factors, hormone production by tumor tissue and hormonal sensitivity of the latter, genesis, dichotomy and endocrinology of cancer in females, and pharmacogenomics and proteomics in oncoendocrinology.
Inhibitors of protein kinases and protein phosphates
The aims of this volume are to highlight the tremendous pharmacological potential of protein kinase and protein phosphatase inhibitors, to provide a thorough overview of the most remarkable achievements in the field and to illustrate how beneficial these studies can be for the advancement of both basic knowledge on biological regulation and deregulation and for the clinical treatment of a wide spectrum of diseases.
Hypertension in the Elderly
Topics range from basic concepts, epidemiology and trials, and evaluation and management, to pharmacological treatment, special populations, and adherence, all presented with an emphasis on the optimal management of patients. The authors examine in detail the mechanisms of hypertension in the elderly, particularly age-related changes in vascular stiffness, and methodically review the lifestyle and outcomes trials that were conducted in older persons. The problems of clinical evaluation, secondary hypertension, and target organ damage are also fully addressed, and a practical approach is provided for correctly determining blood pressure, one of the most important tasks in evaluating an older patient. Extensive discussions of pharmacological therapy detail the role of individual drug classes, including diuretics and b-blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, calcium antagonists, a-1 blockers, and combination drug therapies. Additional chapters focus on special populations, such as African Americans, patients with diabetes, and patients with arthritis, as well as on the clinician's role in improving therapeutic adherence in older patients. Offers family practitioners and general internists an up-to-date, user-friendly reference on the diagnosis, treatment, and complications of hypertension in the elderly.
Human battle against obesity
Obesity is one of the most common preventable diseases and it is a medical condition in which excess fat has accumulated in the body, mostly in the subcutaneous tissues. Clinical obesity is considered to be present when a person has a body mass index of 30 or over. Obesity results from a chronic positive energy balance regulated by a complex interaction between endocrine tissues and the central nervous system, This activity reviews the pathophysiology of obesity, inflammatory markers secreted by excessive fat deposition in adipose tissue, and their effects on chronic diseases such as hypertension, diabetes, and dyslipidemia.
Hormones, metabolism and the benefits of exercise
The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.
Honey and olive oil in diabetic foot therapy
At the beginning of the 21st Century diabetic foot is Observed, although eminently preventable, represent one of the commonest causes of hospital inpatient in Western countries. Diabetic foot is a pathological condition that might affect the feet in patients with diabetes. Foot ulcers are defined as lesions involving a skin break with loss of epithelium: they can extend into the dermis and deeper layers sometimes involving bone and muscle...
Herbals as nutraceuticals : Their role in healthcare
Herbal nutraceuticals demonstrate a variety of therapeutic benefits and have been found to prevent, treat, and even cure a range of diseases. This new book provides insight into nutraceuticals and their function in human health, highlighting their antimicrobial and immune-inflammatory properties. It describes the nutraceutical properties of various medicinal herbs and details the role of nutraceuticals in treating diseases such as Alzheimer's, Parkinson's, obesity, diabetes, cancer, cardiovascular diseases, skincare issues, and more.
Healthcare solutions using machine learning and informatics
Covers novel and innovative solutions for the healthcare that apply machine learning and biomedical informatics technology. The healthcare sector is one of the most critical in society. This book presents a series of artificial intelligence, machine learning, intelligent IoT-based solutions for medical image analysis, medical big data processing, disease predictions. Machine learning and artificial intelligence use cases in healthcare presented in the book give researchers, practitioners, and students a wide range of practical examples of cross-domain convergence. The wide variety of topics covered include: Artificial Intelligence in healthcare Machine learning solutions for such disease as diabetes, arthritis, cardiovascular disease, and COVID-19 Big data analytics solutions for healthcare data processing Reliable biomedical applications using AI models Intelligent IoT in healthcare. The book explains fundamental concepts as well as the advanced use cases illustrating how to apply emerging technologies such as machine learning, AI models, data informatics into practice to tackle challenges in the field of healthcare with real-world scenarios. Chapters contributed by noted academicians and professionals examine various solutions, frameworks, applications, case studies, and best practices in the healthcare domain
Handbook of nutrition and pregnancy
This book discusses relevant topics in the scientific community such as determining to what extent prenatal and perinatal environmental factors are linked to childhood and adult obesity and chronic diseases. This book also examines issues that are common to both the developed and the developing worlds and includes chapters that are specific to nutritional and reproductive factors seen mainly in developing countries. These chapters discuss contemporary issues that impact both the woman and the developing infant. Also covered in several chapters is a review of nutritional as well as physiological factors that either increase or decrease the potential for high risk pregnancies such as gestational diabetes mellitus, Type I and Type II diabetes mellitus, preeclampsia, anemia, and so forth.
Handbook of nutrition and ophthalmology
The Handbook of Nutrition in Ophthalmology is the first general text on nutrition and eye health created for physicians, nutritionists, and researchers. Dr. Richard D. Semba provides important links between the epidemic of obesity and implications it has for eye disease and blindness. The volume addresses three broad themes throughout. The first is that a healthy diet as a major lifelong habit will likely have an impact on reducing a substantial portion of visual impairment and blindness. The second is that a historical perspective is essential to understanding current challenges in ophthalmology, medicine, and public health. The third theme is that many nutrients play a role in oxidative stress and inflammation, and this theory has emerged as a major underlying hypothesis in the pathogenesis of eye diseases.
Handbook of Life Course Health Development
Synthesizes and analyzes the growing knowledge base on life course health development (LCHD) from the prenatal period through emerging adulthood, with implications for clinical practice and public health. It presents LCHD as an innovative field with a sound theoretical framework for understanding wellness and disease from a lifespan perspective, replacing previous medical, biopsychosocial, and early genomic models of health. Interdisciplinary chapters discuss major health concerns (diabetes, obesity), important less-studied conditions (hearing, kidney health), and large-scale issues (nutrition, adversity) from a lifespan viewpoint. In addition, chapters address methodological approaches and challenges by analyzing existing measures, studies, and surveys. The book concludes with the editors’ research agenda that proposes priorities for future LCHD research and its application to health care practice and health policy.
Handbook of Diabetes Management
Over 18 million Americans are afflicted. Nearly as many are at risk. Diabetic conditions account for one-fifth of the nation’s chronic health care burden. A public health crisis of this magnitude demands professional resources that apply evidence-based practical knowledge and anticipate the challenges that lie ahead. The Handbook of Diabetes Management is one such reference, addressing the complexity of the disease, the diversity of the populations it affects, and the continued improvement of care systems.
Glucose Sensing
This volume incorporates authoritative analytical fluorescence-based glucose sensing reviews specialized enough to be attractive to professional researchers, yet also appealing to the wider audience of scientists in related disciplines of fluorescence. Glucose Sensing is an essential reference for any lab working in the analytical fluorescence glucose sensing field. All academics, bench scientists, and industry professionals wishing to take advantage of the latest and greatest in the continuously emerging field of glucose sensing, and diabetes care & management, will find this volume an invaluable resource.
Global Health Collaboration : Challenges and Lessons
Details the innovative work of the Pan Institution Network for Global Health in creating collaborative research-based answers to large-scale health issues. Equitable partnerships among member universities representing North America, Africa, Asia, and Europe reverse standard cross-national dynamics to develop locally relevant responses to health challenges as well as their underlying disparities. Case studies focusing on multiple morbidities and effects of urbanization on health illustrate open dialogue in addressing HIV, maternal/child health, diabetes, and other major concerns. These instructive examples model collaborations between global North and South as meaningful steps toward the emerging global future of public health.
Genomics in Endocrinology : DNA Microarray Analysis in Endocrine Health and Disease
Genomics in Endocrinology focuses on exciting new advances in endocrinology resulting from DNA microarray studies and includes a comprehensive introduction to the use of DNA microarrays in endocrinology. The volume provides the basis for further understanding of the usefulness of microarray analyses in endocrinology research.
Gene Therapy for Cancer
The possibility of treating cancer, a disease defined by genetic defects, by introducing genes targeting these very alterations has led to an immense interest in gene therapy for cancer. Although incremental successes have been realized, enthusiasm for gene therapy has declined due to an increasing number of obstacles. These obstacles include vector systems that do not reach systemic metastases, therapeutic genes with redundant mec- nisms allowing for cellular resistance, and toxicities in clinical trials leading to premature closure of these studies. Different tactics to overcome or circumvent these obstacles have catalyzed the development of a wide range of gene therapy approaches. Thus far, almost two-thirds of gene therapy trials have focused on cancer. This reflects the concept that gene therapy approaches for the treatment of cancer do not necessarily require long-term expression of the gene as is necessary for the treatment of primary genetic defects like hemophilia or juvenile diabetes.
Fundamentals of Geriatric Medicine : A Case-Based Approach
This handbook addresses the complexity of disease prevention and presentation in elderly patients, as well as geriatric pharmacology. Medicare and Medicaid, and conditions common to elderly patients, including depression, dementia, and hypertension, are also covered. Numerous graphs and tables are included throughout the book to assist the reader in processing the information presented and incorporating it into clinical practice. This practical guide is an essential resource for all those caring for the elderly.
Flexibility : A concise guide to conditioning, performance enhancement, injury prevention, and rehabilitation
This groundbreaking book is a definitive guide to flexibility and revises the conceptual framework of the field. In Flexibility: A Concise Guide, the authors provide a fresh perspective on flexibility, one that challenges current thinking and professional practice, from the conceptual foundations of research to the practical applications of stretching techniques in a number of domains.
Feldman and Pike's vitamin D; Vol. 2 : Health, disease and therapeutics
Covers the evidence for new roles of vitamin D, ranging from organ transplantation to cancer, diabetes, inflammatory bowel disease, multiple sclerosis, and renal disease. The coverage is appropriately broad, drawing on aspects of internal medicine, pediatrics, nutrition, orthopedics, oncology, neurology, obstetrics and gynecology, and immunology, as well as, new areas for vitamin D including sports medicine, opthalmology, veterinary medicine and ICU care – including COVID-19. Clinical researchers will gain a strong understanding of the molecular basis for a particular disease and better understand future directions for research in this still-growing field.
Fatty acids
Fatty acid metabolism, including the de novo synthesis, uptake, oxidation, and derivation of fatty acids, plays several important roles at cellular and organ levels. Recent studies have identified characteristic changes in fatty acid metabolism in idiopathic pulmonary fibrosis (IPF) lungs, which implicates its dysregulation in the pathogenesis of this disorder. Here, we review the evidence for how fatty acid metabolism contributes to the development of pulmonary fibrosis, focusing on the profibrotic processes associated with specific types of lung cells, including epithelial cells, macrophages, and fibroblasts. We also summarize the potential therapeutics that target this metabolic pathway in treating IPF.
