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New Concepts of Antiviral Therapy
Antiviral drugs are important tools for treatment or prevention of viral infections. These drugs were first used for monotherapy, but nowadays combinations of antiviral agents are often part of a standard treatment as evidenced by e.g. HAART (highly active antiretroviral therapy). However, in almost every case of antiviral therapy, drug resistant viruses appear. In addition, the low oral bioavailability, toxicity and the number of severe side effects still pose significant problems. All of the latter issues limit the clinical usefulness and drive the need for improved antiviral strategies. These strategies include new drugs and targets, novel modes of action, vector-based treatments and even the block of defined genes by inhibiting mRNA formation (siRNA).
New Aspects of Zirconium Containing Organic Compounds
Metal carbene complexes have made their way from organometallic curiosities to valuable reagents and catalysts. They offer novel synthetic opportunities in carbon-carbon bond formation based on either carbene-centered reactions or on metal-templated processes which makes them indispensable in modern synthetic methodology. The most prominent metal carbenes are now either commercially available or easy to synthesize and handle with modern laboratory techniques. This volume organized in eight chapters written by the leading scientists in the field illustrates the theoretical background, non-classical nucleophilic and cycloaddition patterns, chromium-templated benzannulation and photo-induced reactions, rhodium-catalyzed carbene transfer as well as the principles and applications of olefin metathesis which has coined the progress in synthetic methodology over the past decade. Designed for researchers in academia and industry as well as graduate students it presents the state-of-the-art potential of carbene complexes in modern organic synthesis.
Neuroprotection : Method and protocols
Contains cutting-edge molecular biology methods on neuroprotective mechanisms and specific preclinical models of the CNS injury, iseases and planning translation. Chapters guide readers through neuropathology, neuroprotection, Alzheimer’s disease, amyotrophic lateral sclerosis, ALS, Huntington’s disease , multiple sclerosis, Parkinson’s disease, spinal cord injury, traumatic brain injury, and ischemic brain injury. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Neurobiology : Methods and protocols
Serves as a guide for students in the field of neurobiology, and be a bridge between basic science researchers, doctors, and surgeons in clinical practice. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Net-Centric Approaches to Intelligence and National Security
Net-Centric Approaches to Intelligence and National Security considers the web architectures and recent developments that make net-centric approaches for intelligence and national security possible. The development of net-centric approaches for intelligence, national & homeland security applications has become a major concern in many areas such as defense intelligence and national and international law enforcement agencies, especially since the terrorist attacks of 9/11. Net-Centric Approaches to Intelligence and National Security presents developments in information integration and recent advances in web services including the concept of the semantic web. Discovery analysis and management of web-available data pose a number of interesting challenges for research in web-based management systems. Intelligent agents and data mining are among the techniques employed. A number of specific systems that are net-centric based in various areas of military applications, intelligence and law enforcements are presented utlilizing one or more of such techniques Net-Centric Approaches to Intelligence and National Security is designed for a professional audience of researchers and practitioners in industry. This volume is also suitable for graduate-level students in computer science.
Negotiation, auctions, and market engineering ; International Seminar, Dagstuhl Castle, Germany, November 12-17, 2006, Revised Selected Papers
This book contains a selection of papers presented at the International Seminar "Negotiation and Market Engineering", held at Dagstuhl Castle, Germany, in November 2006.The 17 revised full papers presented in this volume were carefully selected and reviewed after the seminar. The papers deal with the complexity of negotiations, auctions, and markets as economic, social, and IT systems. The authors give a broad overview on the major issues to be addressed and the methodologies used to approach them, covering highly interdisciplinary research from computer science, economics, business administration, and mathematics.
Nanomaterials and Nanosystems for Biomedical Applications
The book includes expert reviews on the advances and current problems associated with the implants and nanodevices along with their applications in medicine, pharmaceutics, cancer therapy, gene transfer and drug delivery. The editor, M. R. Mozafari (PhD), has been working in the field of nanobiotechnology for the past 14 years and has produced more than 60 publications.
Nanocarrier Technologies : Frontiers of Nanotherapy
Nanobiotechnology is one of the key technologies of the 21st century. It is a combination of nanoscience and biotechnology and covers areas ranging from gene transfer and nanoencapsulation to food technology. Nanocarriers are a leading nanobiotechnology tool with the ability to provide protection, site-specific delivery, enhanced bioavailability and controlled release of pharmaceuticals, genetic material, imaging agents, nutraceuticals and cosmetics to name a few. For this reason, the study of nanocarriers, their properties and applications has attracted a great deal of interest over recent years. Designed as an advanced survey of the field, this book describes the key research parameters of nanocarrier technologies including their preparation methods, evaluation of their safety and efficiency, their interaction with biologicals and their application in biotechnology, drug delivery, gene therapy and food technology areas.
Muscle hypertrophy and role of anabolic hormones in bodybuilding
The goal of our research first of all to give an overall view on the physiology of muscles and we will focus on natural elements such as diet and exercises to improve your aim without using chemical drugs, we will also include other factors affecting hypertrophy muscle such as genetic ones since the variation in between two sportive persons might be more than 50 percent determined by heredity which is a very important element and may lead a sportive man to elevate the doses to reach the same development of ideal muscles.
Multi-Scale Approaches in Drug Discovery : From Empirical Knowledge to In silico Experiments and Back
Drug discovery is an expensive, time-consuming process and the modern drug discovery community is constantly challenged not only with discovering novel bioactive agents to combat resistance from known diseases and fight against new ones, but to do so in a way that is economically effective. Advances in both experimental and theoretical/computational methods envisage that the greatest challenges in drug discovery can be most successfully addressed by using a multi-scale approach, drawing on the specialties of a whole host of different disciplines. Multi-Scale Approaches to Drug Discovery furnishes chemists with the detail they need to identify drug leads with the highest potential before isolating and synthesizing them to produce effective drugs with greater swiftness than classical methods may allow. This significantly speeds up the search for more efficient therapeutic agents.
Multiple Sclerosis: Autoimmunity and Management
Multiple sclerosis (MS) is an immune-mediated inflammatory disease that attacks myelinated axons in the central nervous system, destroying the myelin and the axon in variable degrees and producing significant physical disability within 20–25 years in more than 30% of patients. The hallmark of MS is symptomatic episodes that occur months or years apart and affect different anatomic locations. Also, see the Autoimmune Disorders: Making Sense of Nonspecific Symptoms slideshow to help identify several diseases that can cause a variety of nonspecific symptoms. MS is diagnosed on the basis of clinical findings and supporting evidence from ancillary tests. Treatment consists of immunomodulatory therapy for the underlying immune disorder and management of symptoms, as well as nonpharmacologic treatments, such as physical and occupational therapy. Disease-modifying therapies have shown beneficial effects in patients with relapsing MS, including reduced frequency and severity of clinical attacks. These agents appear to slow the progression of disability and the reduce accumulation of lesions within the brain and spinal cord.
Multimodal Concepts for Integration of Cytotoxic Drugs
The first part of this book summarizes the rationale and the preclinical data for combined treatment with ionizing radiation and pharmaceutical agents. Individual chapters focus on different forms of combined treatment, with due consideration being given to a range of drugs and to emerging combinations with small molecules and antibodies, derived from recent advances in molecular oncology. The second part of the book comprises a series of disease-specific chapters in which the clinical results of combined modality treatment are presented. In addition, the topics of acute and late toxicity, supportive treatment and tolerance in elderly patients are reviewed.
Multifunctional systems for combined delivery, biosensing and diagnostics
Multifunctional Systems for Combined Delivery, Biosensing, and Diagnostics explores how multifunctional nanocarriers are being used in combined delivery and diagnostics in contemporary medicine. Particular attention is given to efforts to i) reduce the side effects of therapeutic agents, ii) increase the pharmacological effect, and iii) improve aqueous solubility and chemical stability of different therapeutic agents. The chapters focus on applications of nanostructured materials and nanocarriers, highlighting how these can be used effectively in both diagnosis and delivery.
Multifunctional Pharmaceutical Nanocarriers
Various pharmaceutical nanocarriers, such as nanospheres,nanocapsules, liposomes, micelles, cell ghosts, lipoproteins and some others are widely used for experimental (and already clinical) delivery of therapeutic and diagnostic agents. The use of nanoparticulate pharmaceutical carriers to enhance the in vivo efficiency of many drugs well established itself over the past decade both in pharmaceutical research and clinical setting.
Multi-Agent-Based Simulation VIII ; International Workshop, MABS 2007, Honolulu, HI, USA, May 15, 2007, Revised and Invited Papers
This book constitutes the thoroughly refereed post-proceedings of the 8th International Workshop on Multi-Agent-Based Simulation, MABS 2007, held in Honolulu, HI, USA in May 2007 as an associated event of AAMAS 2007, the main international conference on autonomous agents and multi-agent systems.The 10 revised full papers presented were carefully reviewed and selected from 20 submissions.The papers are organized in topical sections on architectures; teams, learning, education; economy, trust and reputation.
Multi-Agent-Based Simulation VI ; International Workshop, MABS 2005, Utrecht, The Netherlands, July 25, 2005, Revised and Invited Papers
This book constitutes the thoroughly refereed post-proceedings of the 6th International Workshop on Multi-Agent-Based Simulation, MABS 2005, held in Utrecht, The Netherlands in July 2005 as an associated event of AAMAS 2005, the main international conference on autonomous agents and multi-agent systems. The 12 revised full papers presented together with 1 invited talk were carefully reviewed. The papers are organized in topical sections on coalition emergence, theories and models, applications, and environments.
Multi-Agent Systems and Applications V ; 5th International Central and Eastern European Conference on Multi-Agent Systems, CEEMAS 2007, Leipzig, Germany, September 25-27, 2007, Proceedings
The technical research paper section of the proceedingscontains pure - search papers as well as research results in application settings. The goal is to demonstrate the real-life value and commercial reality of multi-agent systems as well as to foster the communication between academia and industry in this eld.
Multi-Agent Systems and Applications IV ; 4th International Central and Eastern European Conference on Multi-Agent Systems, CEEMAS 2005, Budapest, Hungary, September 15-17, 2005, Proceedings
In the very competitive field of agent oriented conferences and workshops nowadays (such as AAMAS, WI/IAT, EUMAS, CIA, MATES) the special profile of CEEMAS is that it is trying to bridge the gap between applied research achievements and theoretical research activities. Our ambition is to provide a forum for presenting theoretical research with an evident application potential, implemented application prototypes and their properties, as well as industrial case studies of successful (but also unsuccessful) agent technology deployments. This is why the CEEMAS proceedings volume provides a collection of research and application papers. The technical research paper section of the proceedings (see pages 11–499) contains pure research papers as well as research results in application settings while the application papers section (see pages 500–530) contains papers focused on application aspects. The goal is to demonstrate the real life value and commercial reality of multi-agent systems as well as to foster communication between academia and industry in this field.
Multi-Agent Systems and Applications ; 9th ECCAI Advanced Course ACAI 2001 and Agent Link's 3rd European Agent Systems Summer School, EASSS 2001, Prague, Czech Republic, July 2-13, 2001. Selected Tutorial Papers
The Advanced Course on Artificial Intelligence ACAI 2001 with the subtitle M ulti- Agent Systems and Their Applications , held in Prague, Czech Republic, was a joint event of ECCAI (the European Coordinating Committee for Artificial Intelligence) and AgentLink, the European Network of Excellence for Agent-Based Computing. Whereas ECCAI organizes two-week ACAI courses on different topics every second year, AgentLink s European Agent Systems Summer School (EASSS) has been an annual event since 1999. This year, both of these important events were merged together, giving weight to the fact that multi-agent systems currently represent one of the hottest topics in AI research. The name, ACAI 2001 Summer School, is intended to emphasize that this event continues the tradition of regular ECCAI activities (ACAI), as well as the EASSS summer schools of AgentLink.
Multiagent System Technologies ; Vol. 4196 ; 4th German Conference, MATES 2006, Erfurt, Germany, September 19-20, 2006, Proceedings
This book constitutes the refereed proceedings of the 4th German Conference on Multiagent Systems Technologies, MATES 2006, co-located with Net.ObjectDays (NoDe 2006). The 15 revised full papers presented were carefully reviewed and selected from 52 submissions. The papers are organized in topical sections on agent communication and interaction, applications and simulation, agent planning, agent-oriented software engineering, as well as trust and security.
