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Multi-slice and Dual-source CT in Cardiac Imaging : Principles - Protocols - Indications - Outlook
Cardiac diseases, and in particular coronary artery disease, are the leading cause of death and morbidity in industrialized countries. The development of non-invasive imaging techniques for the heart and the coronary arteries has been considered a key element in improving patient care. A breakthrough in cardiac imaging using CT occurred in 1998, with the introduction of multi-slice computed tomography (CT). Since then, amazing advances in performance have taken place with scanners that acquire up to 64 slices per rotation. This book discusses the state-of-the-art developments in multi-slice CT for cardiac imaging as well as those that can be anticipated in the future
Multidetector-Row CT Angiography
Multidetector-row CT has dramatically improved the results of computed tomography in all clinical applications, but its beneficial impact has been most striking in vascular imaging. The simplicity of acquisition and the wide availability of equipment make this modality especially suitable for routine clinical application. In this book the basic aspects of multidetector-row CT angiography are comprehensively reviewed. Individual chapters are included on technical principles, image processing techniques and contrast agent administration. All clinical applications are then discussed in depth, with lucid descriptions of the examination technique for particular clinical indications and of the findings that characterize specific diseases. Limitations and advantages in comparison with other imaging modalities are considered. A large number of high-quality black and white and color illustrations help to explain the clinical findings.
Multidetector-Row Computed Tomography : Scanning and Contrast Protocols
Multidetector-row computed tomography (MDCT) has advanced the approach to diagnostic assessment of many pathologies and now plays an integral role in imaging of both abdominal and cardiovascular diseases. The possibility to acquire diagnostic images with shorter scan duration, longer scan ranges, and/or thinner sections, MDCT has facilitated the opening of new horizons, such as interventional MDCT and functional imaging in stroke and oncology. In addition, advanced postprocessing techniques now permit high quality volumetric imaging in combination with maximum intensity projections, volume rendering, curved planar reformations and multiplanar reconstructions. This volume gathers contributions by internationally renowned specialists in the field who, through presenting their clinical experience, provide a thorough overview not only of MDCT and its practical applications, but also of workflow management in everyday clinical practice. Focussing on scanning and contrast protocols, the current advantages and disadvantages of non-enhanced vs. enhanced MDCT are discussed, along with insights into likely future developments. The volume represents an up-to-date source of technical and practically-oriented clinical information which should prove of great benefit to all who wish to improve or consolidate their knowledge and expertise in MDCT.
MRI of the Heart and Vessels
In recent years magnetic resonance imaging (MRI) has enriched the technological potential available for the characterization of cardiovascular pathologies, adding substantial advantages to other non-invasive techniques. This technique, which is intrinsically digital and has reduced operator dependency, allows the performance of image analysis in a quantitative and reproducible manner. In virtue of its added diagnostic value and inherent refinements that allow construction of two- and three-dimensional images, MRI is gaining a primary role in the histopathological and physiopathological understanding of a large number of pathologies concerning the heart and vessels. This text is addressed both to MRI operators seeking specific technical information and to clinicians who wish to have a better understanding of the diagnostic and management advantages that MRI can offer.
Mortality and Maldevelopment : Part I : Congenital cardiovascular malformations
The most frequent of them all are the many types of malformations of the cardiovascular system, the heart and its blood vessels.Study of these conditions during the twentieth century took many forms, revolving about examination and analysis of their causes, genetic, nongenetic, and complex. To aid in unraveling the complexities of this causation, various influences on their frequency are considered, among them social conditions, maternal health, birthweight, newborn maturity. And of course the known and possible environmental bases of their occurrence are fully described.
Molecular Sensors for Cardiovascular Homeostasis
This book reveals state-of-the-science of several newly discovered ion channel families and their role in the pathogenesis of cardiovascular diseases.It offers comprehensive and up-to-date information for a deeper understanding of the relationship between macro- and micro-environments, ion channels, and pathophysiological responses, and for developing novel therapies for treating devastating cardiovascular illnesses.
Molecular mechanisms in nutritional epigenetics
The field of nutritional epigenetics/nutri-epigenetics has expanded significantly, shedding light on how environmentally-driven epigenetic pathways can be modulated through nutrition and eating habits. The book provides a comprehensive introduction to the various epigenetic mechanisms affected by dietary compounds and focuses on specific topics such as the relationship between diet and the gut microbiome, the impact of diet on cardiovascular disease and psychopathology and the role of diet in pregnancy.
Modern Anesthetics
Some important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient’s purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. in this book the very mechanism of anesthetic action at the biophase” was discussed within the theoretical framework of the “u- tary theory of narcosis”.
Modeling of Biological Materials
This interdisciplinary collection of surveys highlights the central role played by the mathematical modeling of mechanical properties having an effect on the biology, chemistry, and physics of living matter. One of the main goals of the book is to present—in a single, self-contained resource—topics that are widely scattered across the literature in a variety of journals having mutually nonintersecting communities of readers, such as applied mathematicians, engineers, biologists, and physicians. Readers coming from diverse backgrounds are provided with basic modeling ideas and tools to address important problems in the medical and health sciences. Presented are appropriate models as well as their implementation through numerical and computer simulations, which may lead to potential technological innovations useful in medicine.
Mitral valve diseases
The heart is a pump consisting of 4 chambers:2 atria and 2 ventricles and 4 valves one of them is mitral valve which is located betweenthe left atrium and the left ventricle and prevents the backward flow of blood.Ithas several unique features: Mitral annulus, two leaflets, the chordae tendineaeand papillary muscles. The mitral valve may become stenotic or may regurgitate. Regurgitation(or leakage of the valve): When the valve (s) do not close completely. Stenosis (or narrowing of the valve): When the valve (s) opening becomes narrowed. Mitral stenosis is categorized as mild, moderate or severe it is typically causedby (Rheumatic fever, A congenital heart, Calcium deposits .....) and it caused severalsymptoms such as: dyspnea, hemoptysis, fatigue, Chest pain and others Where as the Signs and symptoms of mitral valve regurgitation, can include: Abnormal heart sound, Shortness of breath, Heart palpitations, Fatigue, edma, Coughing.
Mitochondria and the Heart
The function of the heart is highly dependent on oxidative energy that is generated in mitochondria. Defects in mitochondrial structure and function can be found in association with cardiovascular diseases. Mitochondria and the Heart discusses the role that mitochondria plays in cardiovascular disease, including biogenesis and function of cardiac mitochondria during normal growth, development and aging. In addition, nonbioenergetic, biogenesis and degradation pathways are explored. Understanding these pathways and the effects that mitochondrial defects have in cardiac pathology is extremely important in establishing the diagnosis and treatment of mitochondrial-based cardiac diseases.
Microcirculation in Cardiovascular Diseases
This book offers an extensive review of the most recent data on the pathophysiological role of structural and functional alterations in the microcirculation, particularly focusing on hypertension and diabetes. It covers several relevant and innovative aspects, including the possible mechanisms involved in the development of microvascular remodeling and rarefaction, the technical approaches available for the detection of microvascular alterations, including non-invasive evaluations, the prognostic role of changes in small resistance artery structure, the possibility of preventing or regressing such alterations with appropriate treatment, and the potential clinical advantages of such intervention.
Menopause
As people live longer, women are spending most of their lives in menopause, affected by a variety of estrogen-related conditions such as osteoporosis, cognitive and cardiovascular decline, increased risk of breast cancer and other symptoms that decrease the overall quality of life. Unfortunately, hormonal therapy was found to be less effective in decreasing the severity of some of these conditions than previously thought and may actually increase the risk of cancer. The aim of this research was to put a spotlight on natural treatments for menopause like changing life style and herbal medicines.
MDCT : A Practical Approach
Computed tomography (CT) is the most rapidly evolving medical imaging technology. This book describes current examination techniques and advanced clinical applications of state-of-the-art multidetector computed tomography (MDCT) scanners in chapters contributed by several distinguished radiologists and clinicians. Each chapter is written from a practical perspective so that radiologists, residents, medical physicists, and radiology technologists can obtain relevant information about MDCT applications in neuroradiology, cardiac imaging, chest, abdominal, and musculoskeletal radiology subspecialties. Each coauthor provides pertinent illustrations and tables for better understanding of current and advanced applications of MDCT scanners. Readers will benefit from the experience these authors describe in chapters on MDCT technology, contrast administration techniques, contrast adverse effects and their management, and advanced applications of MDCT.
Ion channels as targets in drug discovery
Built around ion channel research and, more specifically, ion channels as important therapeutic drug targets. Under the editorial leadership of Gary Stephens in academic research and Edward Stevens from industry, the aim is to bring these strands together to provide a cutting-edge translational reference on ion channel drug discovery. Exploiting our knowledge of ion channel structure and function has clear current and future potential to intervene and correct the pathophysiology associated with debilitating conditions, including cardiovascular disease, diabetes, cystic fibrosis, pain, epilepsy, and neurodegenerative disorders. Individual chapters have a disease focus, also providing a “case study story” that will also appeal to a clinical audience
Introduction to basics of pharmacology and toxicology ; Vol.2 : Essentials of systemic pharmacology : From principles to practice
Describes the pharmacology of drugs acting on different systems in the human body Analyses various human diseases and the pharmacological agents governing them Provides a valuable reference resource for academicians, researchers, and clinical practitioners Offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics.
Intracranial vascular malformations and aneurysms : From diagnostic work-up to endovascular therapy ; 2nd ed.
This book describes the pathoanatomical, pathophysiological, and imaging features of vascular malformations and aneurysms of the brain and the modern, minimally invasive endovascular methods and techniques employed in their treatment.
Intracranial vascular malformations and aneurysms : From diagnostic work-up to endovascular therapy ; 1st ed.
This book describes the pathoanatomical, pathophysiological, and imaging features of vascular malformations and aneurysms of the brain and the modern, minimally invasive endovascular methods or techniques employed in their treatment. Individual chapters are devoted to venous malformations, capillary telangiectasias and cavernomas, pial arteriovenous malformations, dural arteriovenous malformations, and intracranial aneurysms. Each chapter is subdivided into four principal sections on pathology, clinical presentation, diagnostic imaging, and therapy, ensuring a standardized approach throughout. The book is richly illustrated with numerous informative CT, MR and DSA images.
Intensive and Critical Care Medicine : Reflections, Recommendations and Perspectives
The volume will provide an update on problems concerning respiration, cardiovascular medicine, monitoring, organizational aspects and quality of care; other important aspects will be discussed, from critical patients' treatment and informed consent to costs managements, research and auditing, severity scores and control of infections in intensive care. Sepsis and organ dysfunction will be dealt with in detail. A brief account of records of the World Federation of Intensive and Critical Care Medicine introduces some of the drawbacks encountered during its thirty-year-old history.
Integrating lifestyle medicine in cardiovascular health and disease prevention
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States and around the world. Major risk factors for CVD result from poor lifestyle habits and practices, but the area of lifestyle medicine has emerged to help clinicians and their patients understand the power of positive lifestyle habits and actions.
