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Multivariate Statistical Machine Learning Methods for Genomic Prediction
This book brings together the latest genome base prediction models currently being used by statisticians, breeders and data scientists. It provides an accessible way to understand the theory behind each statistical learning tool, the required pre-processing, the basics of model building, how to train statistical learning methods, the basic R scripts needed to implement each statistical learning tool, and the output of each tool. To do so, for each tool the book provides background theory, some elements of the R statistical software for its implementation, the conceptual underpinnings, and at least two illustrative examples with data from real-world genomic selection experiments.
Multiphase Reacting Flows : Modelling and Simulation
This book entitled ''Multiphase reacting flows: modelling and simulation'' contains the lecture notes of the CISM (International Centre for Mechanical Sciences) course held in Udine, Italy, on July 3-7, 2006, and it describes various modelling approaches for dealing with polydisperse multiphase reacting flows. A multiphase reacting system is characterized by the presence of multiple phases and in this book we focus on disperse multiphase systems, where one phase can be considered as a continuum, whereas the additional phases are dispersed in the continuous one. In other words, in this book we deal with multiphase systems constituted by particles, droplets or bubbles (i.e., solid particles suspended in a continuous liquid phase, liquid droplets in a gaseous phase, or gas bubbles in liquid.) The other important characteristic elements of the systems discussed in this book are the presence of one or more chemical reactions and the turbulent nature of the flow. The chemical reactions usually involve all the phases present in the system and might be responsible for the formation or disappearance of the disperse and/or continuous phases.
Move : Architecture in Motion - Dynamic Components and Elements
Dynamic components and adaptive elements are becoming increasingly important in contemporary architecture, and not just because of their visual effect. If architects and engineers are engaging more and more with the issue of movement – whether in the form of sun-tracking solar cells, lowerable walls, or intelligently programmed elevators – it’s because they are busy exploring responses to three challenges: How can we control and reduce the energy requirement of buildings? How can we expand the range of possible uses? And how can we represent, illustrate, accommodate, and control dynamic movements in buildings?
MooTools Essentials : The Official MooTools Reference for JavaScript™ and Ajax Development
Mootools is a light, modular JavaScript framework that makes adding Ajax, animations, and interactive elements to your site a breeze. But it's more than fancy effects and shortcuts; Mootools enhances the JavaScript language and makes writing clean, object–oriented code almost pleasant. Unlocking the power of Mootools, and therefore JavaScript, isn't that hard, but knowing where to start can be.
Molecular Targeting in Oncology
In Molecular Targeting in Oncology, authors present an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application. The volume covers the complexity of the rapidly developing area of targeted therapies for the treatment of patients with cancer and is structured in a way so readers may begin with chapters that most interest them and work through the rest of the chapters in the order of their choice. The volume is divided into five sections that cover the most important elements of drug development. The first section focuses on approaches using targeted therapies to inhibit cell growth. The second section describes how clinicians are evaluating targeted therapies in specific organ systems. The third section illustrates how various classes of pharmacologic and immunologic agents are developed for individual molecular targets. The fourth section details new drugs that have novel mechanisms of action. The final section looks to the future of targeted therapeutics and includes chapters on appropriate patient selection, use of combination therapy, dealing with tumor cell resistance, and more. Comprehensive and cutting-edge, Molecular Targeting in Oncology is an essential reference for those working in the field.
Molecular microbiology of heavy metals
Molecular Microbiology of Heavy Metals includes chapters on allocation of metals in cells, metal transporter, storage and metalloregulatory proteins, cellular responses to metal ion stress, transcription of genes involved in metal ion homeostasis, uptake of essential metals, metal efflux and other detoxification mechanisms. Also discussed are metal bioreporters for the nanomolar range of concentration and tools to address the metallome. Chapters in the second part cover specific metals such as Fe, Mn, Cu, Ni, Co, Zn and Mo as key nutrient elements and Ag, As, Cd, Hg and Cr as toxic elements.
Molecular genetics, structures, mechanisms, and functions : Applications and exploring the nucleus ; Vol.2
Continues the coverage of generic engineering, dealing with the concept of genes, their relationship with chromosomes, and their functional manifestation to the benefit of organisms at large and for human in particular. Topics include Mendel’s Laws of Inheritance, which explains the inheritance of traits visible through generations; , genome diversity and evolution genetic protein synthesis, recombination and evolution of DNA, transposable elements in genetics, chromosomal aberrations, and more. The volume also addresses genetic engineering in agricultural science for increased crop yields, to reduce costs for food or drug production, to reduce the need for pesticides, to enhance crop quality, etc.
Modellistica numerica per problemi differenziali = Numerical modeling for differential problems
This text introduces the basic concepts for the numerical modeling of partial differential problems. We consider the classic elliptic, parabolic and hyperbolic linear equations, but also other equations, such as those of diffusion and transport, of Navier-Stokes, and the conservation laws, and we provide numerous physical examples underlying these equations. Then we analyze numerical resolution methods based on finite elements, finite differences, finite volumes, spectral methods and domain decomposition methods. In particular, the algorithmic and computer implementation aspects are discussed and various easy-to-use programs are provided.
Modellistica Numerica per Problemi Differenziali = Numerical Modeling for Differential Problems
This text introduces the fundamental concepts for the numerical modeling of partial differential problems. We consider the classic linear elliptic, parabolic and hyperbolic equations, but also other equations, such as those of diffusion and transport, of Navier-Stokes, and the conservation laws. Numerous physical examples underlying these equations are provided, their main mathematical properties are studied, then numerical resolution methods based on finite elements, finite differences, finite volumes and spectral methods are proposed and analyzed. In particular, the algorithmic and computer implementation aspects are discussed and some easy-to-use programs in C ++ language are provided. The text does not presuppose an advanced mathematical knowledge of partial differential equations: the strictly indispensable concepts in this regard are reported in the Appendix. The volume is therefore suitable for students of scientific degree courses (Engineering, Mathematics, Physics, Chemistry, Information Sciences) and recommended for researchers from the academic and extra-academic world who want to approach this interesting branch of applied mathematics.
Modelling in Mathematical Programming : Methodology and Techniques
This book provides basic tools for learning how to model in mathematical programming, from models without much complexity to complex system models. It presents a unique methodology for the building of an integral mathematical model, as well as new techniques that help build under own criteria. It allows readers to structure models from the elements and variables to the constraints, a basic modelling guide for any system with a new scheme of variables, a classification of constraints and also a set of rules to model specifications stated as logical propositions, helping to better understand models already existing in the literature. It also presents the modelling of all possible objectives that may arise in optimization problems regarding the variables values. The book is structured to guide the reader in an orderly manner, learning of the components that the methodology establishes in an optimization problem. The system includes the elements, which are all the actors that participate in the system, decision activities that occur in the system, calculations based on the decision activities, specifications such as regulations, impositions or actions of defined value and objective criterion, which guides the resolution of the system.
Mixed Finite Elements, Compatibility Conditions, and Applications : Lectures given at the C.I.M.E. Summer School held in Cetraro, Italy June 26–July 1, 2006
Since the early 70's, mixed finite elements have been the object of a wide and deep study by the mathematical and engineering communities. The fundamental role of this method for many application fields has been worldwide recognized and its use has been introduced in several commercial codes. An important feature of mixed finite elements is the interplay between theory and application. Discretization spaces for mixed schemes require suitable compatibilities, so that simple minded approximations generally do not work and the design of appropriate stabilizations gives rise to challenging mathematical problems.
Micronutrients and macronutrients as nutraceuticals
Explains in detail the properties of micronutrients and macronutrients and their diverse uses as nutraceuticals for their beneficial properties, such as their antioxidant activity and immunity-boosting properties and how they can be incorporated into the human diet for optimum health, for growing beneficial bacteria in the gut, and inhibition of pathogens. Interestingly, the authors look at how disease-promoting habits often unfold in childhood, even prenatally, and employing nutrigenomics early on goes a long way toward curbing these chronic diseases later on in life.
Microbial Sulfur Metabolism
In nature, sulfur occurs in many different oxidation states and is one of the most versatile elements in life. It is an integral part of many important cell constituents, such as the amino acids cysteine and methionine, and many sulfur compounds serve as the basis for energy-related processes in prokaryotes. In recent years, new methods have been applied to study the biochemistry and molecular biology of reactions of the global sulfur cycle, the microorganisms involved and their physiology, metabolism and ecology. These activities have uncovered fascinating new insights for the understanding of aerobic and anaerobic sulfur metabolism.
Microbial Linear Plasmids
Microbial Linear Plasmids constitutes the first attempt to comprehensively assemble current knowledge of different types of such elements, highlight recent developments in the field, and challenge the distinction between viruses and linear plasmids.
Methods and Tools for Drought Analysis and Management
Implementation of effective drought management policies requires both advanced technologies and appropriate methods. Monitoring and forecasting systems, practical tools for risk assessment, as well as simple and objective criteria to select and implement appropriate drought mitigation measures are key elements for a successful drought management strategy.These key issues have been tackled by universities and public agencies involved in the EU projects Sedemed and Sedemed II (Programme Interreg IIIB MEDOCC), aimed at the definition of an integrated network for real time monitoring of drought, the development of common methodologies for drought analysis and forecasting, as well as the definition of proper mitigation strategies for the Mediterranean countries.The book presents the main outcomes of such projects with a special focus on: drought monitoring and forecasting echniques at different spatial scales; new or modified agrometeorological indices and remote sensing technique for drought identification and characterization; tools to improve surface water resources management under drought conditions; methods and tools for groundwater resources monitoring and management, based on hydrogeological and hydrodynamics characteristics of aquifers; general criteria to select and implement mitigation strategies to prevent or minimize drought impacts.
Metal-containing molecules and nanomaterials : from diagnosis to therapy
Since the discovery and successful deployment of salvarsan to treat syphilis, as well as cisplatin as a cancer drug, the field of metallodrugs has been flourishing. In addition to therapeutic applications, metals and metal-containing molecules have properties, such as an electrochemical or an optical signal, used to diagnose biologically relevant molecules or unravel cellular metabolism. Metals are part of the essential elements for life, and of increased attention in nutraceuticals. Most of the current diagnosis processes, therapeutics and nutraceuticals are based on organic molecules. MILS-26 reviews the most recent metal-containing molecules and nanomaterials for diagnosis and therapy
Metakaolin and Fly Ash as Mineral Admixtures for Concrete
Deals with modern theoretical concepts related to the impact of fly ash and metakaolin admixtures on structure formation processes of concrete. Results of the effect of fly ash, metakaolin and their composition on properties of self-compacting and self-leveling concrete are presented. Based on mathematical models, obtained using mathematical experiments planning methodology, the impact of the main factors and their combination on workability, strength and other properties that determine efficiency and durability of concrete are analyzed. Using calculated dependencies, a methodology for designing optimal compositions of concrete containing active mineral admixtures and superplasticizers is proposed. Features of industrial production of concrete for the proposed compositions are discussed. The book is intended for specialists working in the production of concrete and reinforced concrete products and elements. It can also be used by construction engineers to design compositions of cost-effective self-compacting and self-leveling concrete as well as to determine the rational direction of using technogenic raw materials like ash and metakaolin.
Metaheuristics for Hard Optimization : Methods and Case Studies
Metaheuristics for Hard Optimization comprises of three parts. The first part is devoted to the detailed presentation of the four most widely known metaheuristics: the simulated annealing method, tabu search, the evolutionary algorithms, and ant colony algorithms. Each one of these metaheuristics is actually a family of methods, of which the essential elements are discussed. In the second part, the book presents some other less widespread metaheuristics, then, extensions of metaheuristics and some ways of research are described . The problem of the choice of a metaheuristic is posed and solution methods are discussed. The last part concentrates on three case studies from telecommunications, air traffic control, and vehicle routing.
Metaheuristic Optimization via Memory and Evolution : Tabu Search and Scatter Search
Tabu Search (TS) and, more recently, Scatter Search (SS) have proved highly effective in solving a wide range of optimization problems, and have had a variety of applications in industry, science, and government. The goal of METAHEURISTIC OPTIMIZATION VIA MEMORY AND EVOLUTION: Tabu Search and Scatter Search is to report original research on algorithms and applications of tabu search, scatter search or both, as well as variations and extensions having "adaptive memory programming" as a primary focus. Individual chapters identify useful new implementations or new ways to integrate and apply the principles of TS and SS, or that prove new theoretical results, or describe the successful application of these methods to real world problems.The chapters of this book provide a series of landmarks along the way as we investigate and seek to better understand the elements of tabu search and scatter search that account for their successes in an astonishingly varied range of applications.
Metaheuristic Optimization Algorithms in Civil Engineering : New Applications
Discusses the application of metaheuristic algorithms in a number of important optimization problems in civil engineering. Advances in civil engineering technologies require greater accuracy, efficiency and speed in terms of the analysis and design of the corresponding systems. As such, it is not surprising that novel methods have been developed for the optimal design of real-world systems and models with complex configurations and large numbers of elements.
