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Antisense RNA Design, Delivery, and Analysis
This volume gathers a variety of models, delivery systems, and approaches that can be used to assess RNA technology for exploiting antisense as a therapeutic intervention. Beginning with a section on the design of antisense technology and their delivery, the book continues by covering model systems developed to evaluate efficacy, both in vivo and in vitro, as well as methods to evaluate preclinically the toxicity associated with these new potential drugs, and intellectual property considerations. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Antioxidants effects in health : The bright and the dark side ; 1st ed.
Examines the role that antioxidants play in a variety of health and disease situations. The book discusses antioxidants’ historical evolution, their oxidative stress, and contains a detailed approach of 1) endogenous antioxidants, including endogenous sources, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; 2) synthetic antioxidants, including sources, chemistry, bioavailability, legal status, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; and 3) natural antioxidants, including sources, chemistry, bioavailability, mechanisms of action, possible prooxidant activity; beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies. Throughout the boo, the relationship of antioxidants with different beneficial and detrimental effects are examined, and the current controversies and future perspectives are addressed and explored. Antioxidants Effects in Health: The Bright and the Dark Side evaluates the current scientific evidence on antioxidant topics, focusing on endogenous antioxidants, naturally occurring antioxidants and synthetic antioxidants. It will be a helpful resource for pharmaceutical scientists, health professionals, those studying natural chemistry, phytochemistry, pharmacognosy, natural product synthesis, and experts in formulation of herbal and natural pharmaceuticals.
Anti-Obesity drugs
As a chronic and relapsing disease, obesity impairs metabolism and causes diabetes, cardiovascular diseases and cancer. Although behavioral modification is important for the treatment of obesity, it is difficult to achieve an ideal weight or sustain the process of long-term weight loss. Therefore, the obesity control guidelines strongly recommend lifestyle interventions along with medical treatment for patients who are overweight. There is sufficient evidence supporting that pharmacotherapy in combination with behavior-based interventions can result in significant weight loss and improvement of the health.
Antimicrobial peptides and human disease
Microbes are in our midst soon after birth. Thankfully, the number of harmless (and often beneficial) microbes far outnumber those that would do us harm. Our ability to ward-off pathogens in our environment, including those that can colonize our exterior and/or interior surfaces, depends on the integrative action of the innate and adaptive immunity systems. This volume of CTMI, entitled Antimicrobial Peptides and Human Disease, is dedicated to the role of antimicrobial peptides (AMPs) in the innate host defense system of homo sapiens.
Anti-Inflammatory diet
An anti-inflammatory diet may serves as a complementary treatment for many conditions that worsen with chronic inflammation, and an anti-inflammatory diet focuses on fresh fruits and vegetables. Combine a variety of foods that are rich in nutrients, provide a range of antioxidants, and contain healthy fats. Such as fatty fish, green tea, berries, and special herbs such as curcumin, ginger, and licorice. ..
Antifouling Paint Biocides
This volume describes the state-of-the-art advances regarding antifouling paint biocides and provides thorough evaluation of research and information on major topics such as occurrence and levels, environmental fate, analytical techniques and methods for the monitoring and control, environmental modeling, ecotoxicological effects and risk assessment placing emphasis on the knowledge acquired over the last 10 years. The contamination of the aquatic environment by antifouling compounds has been a topic of increasing importance during the last few years. The major classes of antifouling active biocides are discussed including the old-fashioned organotin compounds, the modern organic booster biocides and the promising naturally occurring antifoulant products. Therefore, the reader will get a balanced view of this developing field. Chapters were written by leading experts in their field who critically surveyed all the major areas of progress. This volume is an important resource and can constitute a good grounding in the field of antifouling paint biocides.
Antidiabetic plants for drug discovery pharmacology, secondary metabolite profiling, and ingredients with insulin mimetic activity
Takes an in-depth look at the potential pharmacological applications of 11 important antidiabetic plants, examining their antihyperglycemic, hypoglycemic, and anti-lipidemic properties along with current genome editing research perspectives. Plant natural products, or phytoconstituents, are promising candidates for antidiabetic pharmacological actions. The phytoconstituents, such as fl avonoids, terpenoids, saponins, carotenoids, alkaloids and glycosides, play vital roles in the current and future potent antidiabetic drug development programs. Each chapter reviews a particular plant with antidiabetic properties, explaining the therapeutic aspects, its active antidiabetic compounds, and relevant genome editing technology.
Antidiabetic medicinal plants and herbal treatments
Diabetes is a chronic condition associated with metabolic disorder. Persons suffering from diabetes have shown accelerated levels of blood sugar which often harms the heart, blood vessels, eyes, kidneys, and nerves. Over the past few decades, the prevalence of diabetes has been progressively increasing. Synthetic drugs are used to treat diabetic patients to help control the disorder, but it is shown that numerous medicinal plants and herbal drugs are widely used in several traditional systems of medicine to prevent and treat diabetes. They are reported to produce beneficial effects in combating diabetes and alleviating diabetes-related complications. These plants contain phtyonutrients and phytoconstituents demonstrating protective or disease preventive properties. In many developing countries, herbal drugs are recommended by traditional practitioners for diabetes treatment because the use of synthetic drugs is not affordable.
Anticancer activity in heterocyclic organic structures : A pathway to novel drug development : Part 1
New Directions in Organic & Biological Chemistry, explores the development of cancer therapeutics, focusing on molecular chemistry and advanced drug design approaches. Written by experts in theoretical chemistry and molecular chemistry, they bridge the gap between theoretical chemistry, molecular biology, and drug development. In Part I, they focus on the fundamental properties of heterocyclic compounds and innovative methodologies being employed to enhance therapeutic potential. By exploring various classes of heterocyclic compounds and diverse anticancer mechanisms.
Antibody-drug conjugates and cellular metabolic dynamics
Summarizes the related research achievements in Antibody-drug conjugates (ADCs) and their cell metabolism kinetics. The book has three main parts. The first part describes the basic theory of ADCs, including the basic concept and structure of ADCs, and the relationship between the targets of ADCs and their specific functions. The second part mainly introduces the endocytosis and intracellular metabolism of ADCs, including the relationship between endocytosis and ADC activity, the endocytosis and intracellular transport of ADCs, the distribution and metabolism of ADC in vivo. Then it discusses the new formats and research technology of ADCs, including the application of miniaturized antibodies in ADC synthesis, novel carriers for ADC design, the technology and application of site-specific conjugation, and approaches for analyzing the drug: antibody ratio (DAR), the study of pharmacokinetics of ADCs.
Antibiotics : Methods and protocols
Provides state-of-the-art and novel methods on antibiotic isolation and purification, identification of antimicrobial killing mechanisms, as well as methods for the analysis and detection of microbial responses and adaptation strategies. Antibiotics: Methods and Protocols, Second Edition, guides readers through updated and entirely new chapters on production and design, mode of action, and response and resistance. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Antibacterial effects of Algae
An alarm increase in the rate of emerging of resistance bacteria have been causing a great public concern worldwide. This problem of increasing resistance has necessitated the search for safe and effective factors that may be used to treat persistent bacterial infections or modify the currently available antibiotic. This study deals with the antimicrobial potential assessment of ulva flexuosa , ulva flexuosa was collected from at MAZAR ELKHODER. Crude organic extracts were prepared using methanolic and chloroformic extract and tested against 6 indicator microorganisms using the disk diffusion method and also applied against biofilm ( dental plaque).
Anterior knee pain and patellar instability
This multidisciplinary book reviews the diagnosis and management of anterior knee pain and patellar instability in an eminently clinical and practical manner. The book reviews the therapeutic alternatives, both surgical and non-surgical, emphasizing the considerable importance of minimal intervention and non-surgical methods. Similarly, anterior knee pain following ACL reconstruction is covered in detail.
Another side of drugs
Drug interactions remain an important consequence of pharmacologic intervention. It is clear that the pharmacologic response of a drug can be markedly influenced by concurrent administration of another therapeutic agent or food. These interactions may result in a decreased therapeutic effect or in an increase in the amount and extent of untoward reactions. Despite the well-described and real clinical consequences of certain drug interactions, this aspect of patient care often continues to be overlooked.
Animals in space : From research rockets to the space shuttle
Animals in Space will explain why dogs, primates, mice and other rodents were chosen and tested, at a time when dedicated scientists from both space nations were determined to establish the survivability of human subjects on both ballistic and orbital space flights. It will also recount the way this happened; the secrecy involved and the methods employed, and offer an objective analysis of how the role of animals as spaceflight test subjects not only evolved, but subsequently changed over the years in response to a public outcry led by animal activists. It will explore the ways in which animal high-altitude and space flight research impacted on space flight biomedicine and technology, and how the results - both successful and disappointing - allowed human beings to then undertake that same hazardous journey with far greater understanding and confidence.
Animal cell technology meets genomics ; Proceedings of the 18th ESACT Meeting. Granada, Spain, May 11-14, 2003
Reflects the spirit and scientific excellence of the 18th ESACT meeting in different chapters. This book presents, in form of short papers, a high number of the contributions to the meeting, and has been prepared with the aim to provide a relevant reference of the research efforts in Animal Cell Technology
Anestetici locali in analgesia ostetrica : Il modello MLAC : dalla teoria alla pratica clinica = Local anesthetics in obstetric analgesia : The MLAC model : from theory to clinical practice
This monograph contains a detailed description of the MLAC method and its applications and an extensive and updated review of the most significant studies on the subject and their clinical implications. Studies that use the up-down sequential allocation method have made a significant contribution to clarifying numerous questions that the anesthetist asks himself every day in the delivery room and today rightly flank traditional studies representing, together with them, the primary source of updating and knowledge that are indispensable for good clinical practice based not only on experience but also on evidence and scientific rationale.
ANEMONA : A Mulit-agent Methodology for Holonic Manufacturing Systems
ANEMONA is a multi-agent system (MAS) methodology for holonic manufacturing system (HMS) analysis and design, based on HMS requirements. The development process of ANEMONA provides clear and HMS-specific modeling guidelines for HMS designers, and complete development phases for the HMS life cycle.
Androgen Excess Disorders in Women
The field of androgen excess disorders has advanced substantially since the original publication of this book. The Androgen Excess Society (AES) was founded to bring together investigators in the field. A better understanding of the screening, progression, and molecular genetics of nonclassic adrenal hyperplasia (NCAH) has improved the clinical care and diagnostic accuracy of these patients. New criteria for the diagnosis of the polycystic ovary syndrome (PCOS) were proposed in Rotterdam, criteria that have resulted in controversy and, hopefully, initiation of new studies. The association of insulin resistance with PCOS has been strengthened, and the role of metformin in tre- ing the infertility of the PCOS has been validated. Risks for diabetes and, more cont- versially, cardiovascular disease in women with PCOS have received substantial investigation. Our understanding of the epidemiology and economic impact of these disorders has expanded, emphasizing their critical importance.
Ancient Philosophy of the Self
This volume explores the various ways in which selfhood was approached and conceptualised in antiquity. They also describe how the ancient philosophers understood human agents as capable of causing changes and being affected in and by the world. The themes of persistence, identity, self-examination and self-improvement recur in many of these essays. The articles of the collection combine systematic and historical approaches to ancient sources that range from Socrates to Plotinus and Augustine.
