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Bioactives and pharmacology of Legumes
A variety of bioactives and therapeutics from the legume family (Fabaceae or Leguminosae) are thoroughly detailed. For each species included in the volume, a brief introduction is given, the plant’s bioactive compounds are listed, and its chemical structures shown, followed by their pharmacological activities. Many of these plants have medicinal activities that include antiviral, antimicrobial, antioxidant, anticancer, anti-inflammatory, and antidiabetic, hepatoprotective, nephroprotective and cardioprotective. The biochemical characteristics of the 37 plants included, such as the type of starch, protein, and fibers, can be exploited as binders, excipients, thickeners, and dispersants in the formulation of various products in the pharmaceutical industry. The published literature on the pharmacological activities on each species is reviewed and presented in a concise and clear manner.
Bioactives and pharmacology of lamiaceae
Provides a wealth of information on plants in the Lamiaceae family, noted for their essential oils and bioactives and pharmacological properties. The chapters investigate a wide variety of species, providing for each an introduction, characteristics, properties, distribution, traditional uses, and current and potential pharmacological applications. Aiming to be a resource for the development of new drugs based on species within the Lamiaceae family, the volume discusses 26 species, including bungleweed (Ajuga), Malabar catmint (Anisomeles malabarica), beechwood (Gmelina arborea), Brazilian mint (Hyptis crenata), rosemary (Rosmarinus officinalis L.), holy basil (Ocimum tenuiflorum), and many more.
Bioactive and therapeutic dental materials
Special attention has been given to bioactive materials developed to induce cells differentiation/stimulation, hard tissue formation and exert antimicrobial actions. New innovations are necessary to continue to help reinforcing existing technologies and to introduce new paradigms for treating dental disease and restoring teeth seriously compromised by caries lesions via biomimetic and more biological operative approaches. Dental bioactive materials is arguably the latest research area in dentistry and thus the amount of new research is overwhelming. However, in this day and age of evidence based practice it important for this new information to be distilled into a practical and understandable format.
Bigel : An innovative drug delivery system
Bigel is a promising drug delivery system that modifies the pharmacotherapeutic characteristics of knowing active pharmaceutical ingredient (API).It is a mix between hydrogel and organogel (oleogel). The objective of the present work demonstrates the ability of bigel to overcome the disadvan- tages of both types of gels, including the limited ability to cross lipophilic barriers of the skin for hydrogels and the low patient compliance for organogels due to their stickiness and oily residues. Materials andmethods : Carbomer934, PolyvinylpyrrolidoneK 90 and Castor oil where mixed in a high shear mixer using diferent weight percentages of each. Hence,13 for mulations (BG1 to BG13) prepared by simplex mixture design modelis used to study the inuenceofafore- mentioned ingredients on appearance, dynamicviscosity, pH, stability, microscopicstructure of bigel and to understand the chemical interactions between bigel components, Fouriertrans- form infrared (FTIR) analysis will bereported.
Bee products and their applications in the food and pharmaceutical industries ; 1st ed.
Focuses on the health benefits of selected bee products by looking more closely at their pharmacological potentials and therapeutic applications in coping with various diseases. The book explores some of these products, such as royal jelly, propolis and bee venom, which is highly attractive to the food supplement sector due to the biological actions that are proved by scientific studies. Bee products also attract the cosmetics industry by utilizing those products in various applications such as hair products, toothpaste, sunscreen creams, lip balsams, or facial moisturizing creams. Each chapter focuses on a particular health benefit, providing more compact and detailed information about each activity for a specific interest. The mainframe of the book is based on the medicinal and pharmacological functions of bee products, with the therapeutic applications for each bee product supporting the mechanism of action of their biological functions.
Basis and Treatment of Cardiac Arrhythmias
Incorporating the information related to mechanisms and treatment of cardiac arrhythmia, this book discusses genetics of arrhythmias, cell signalling molecules as potential therapeutic targets and trafficking to the membrane. These approaches and implementations of anti-arrhythmic therapy derive from many decades of research.
Basic principles of drug discovery and development ; 2nd ed.
Presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields.
Basic concepts in medicinal chemistry
Designed to help students incrementally build their knowledge of fundamental concepts of medicinal chemistry and their applications to therapeutic decisions, it is progressively organized. Specific sections of the text have been updated to make potentially confusing concepts easier to understand. Numerous examples and review questions further reinforce learning and analytical skills.
Barile's clinical toxicology : Principles and mechanisms ; 3rd ed.
Examines the complex interactions associated with clinical toxicological events as a result of therapeutic drug administration or chemical exposure. Special emphasis is placed on signs and symptoms of diseases and pathology caused by toxins and clinical drugs. Includes the source, pharmacological and toxicological mechanism of action, detection and identification in body fluids, and treatment of exposure. An overview of protocols for managing various toxic ingestions, and the antidotes and treatments associated with their pathology, are discussed. In addition, effect of toxins on a limited number of body systems and drug-induced adverse drug reactions are also covered
Bacteriophage therapy: From lab to clinical practice
Details new and updated experimental approaches for isolating, formulating, and engineering bacteriophage medicinal products. Authored by leading experts and written in the highly successful Methods in Molecular Biology series format, each chapter includes introductions to their respective topics, lists of the necessary materials and reagents, step-by-step reproducible laboratory protocols, and valuable tips for troubleshooting and avoiding known pitfalls.
Bacteriophage therapy : a potential solution for antibiotic resistance crisis
For many years, humans have been fighting with bacteria, in a matter of fact, bacteria have been winning for the last decade, becoming resistant to every weapon we have; The antibiotics. In order to win the fight humans had to think of alternative ways, like viruses. There is a special type of viruses that have been in a war with bacteria for millenniums, Bacteriophages. Bacteriophages (or phages), the most abundant viral entity of the planet. On the basis of their unique characteristics and anti-bacterial property, phages are being the freshly evaluated taxonomically. Phages replicate inside the host either by lytic or lysogenic mode after infecting and using the cellular machinery of a bacterium. Phage became an important agent for combating pathogenic bacteria in clinical treatments and its related research gained momentum. However, due to recent rise of bacterial resistance on antibiotics, applications of phage (phage therapy) become an unavoidable option of research. In this dissertation, the advantage and limitations of Bacteriophages for use in humans will be discussed. Furthermore, this dissertation deals with recent development of its application in the areas of biotechnology.
Autoimmunity : Methods and protocols
Brings together a comprehensive and up-to-date collection of protocols that reflect the diverse experimental strategies. Chapters detail T-cell, macrophage characterization, neutrophil functional assays, organoid culture methods, spatial transcriptomics, RNA FISH, microRNA profiling, and ribosome profiling. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Atlas of Neuromuscular Diseases : A Practical Guideline
A comprehensive outline of neuromuscular diseases, written by experienced American and European authors. It discusses all aspects of neuromuscular disorders including the cranial nerves, spinal nerves, motor neurone disease, the nerve plexus, peripheral nerves, mononeuropathies, entrapment syndromes, polyneuropathies, the neuromuscular junction, and muscle disease. Each chapter is uniformly structured into anatomy, symptoms, signs, pathogentic possibilities, diagnosis and differential diagnosis, therapy and prognosis. Additionally the diagnostic tools and investigations used in neuromuscular disease are explained and a practical guide is given how to advance from symptoms to syndromes. For each disease the therapeutic options are described. It contains large number of clinical and histologic pictures from the practical experience of the authors and also a number of artists drawings to facilitate the understanding of anatomic structures.
Atlas of confocal laser scanning in-vivo microscopy in ophthalmology : principles and applications in diagnostic and therapeutic
Confocal microscopy with laser scanning technology yields in-vivo images of ocular and ocular adnexal surfaces that are so brilliant that they rival histology in terms of quality.This unique atlas and textbook demonstrates normal in-vivo anatomy of the cornea, limbus and conjunctiva, quantifies various cellular structures using cell-density calculations and establishes correlations between novel optical sections of various diseases of the ocular surface and clinical findings.
Aspirin and omeprazole pellets
The objective of this study was to combine Aspirin and Omeprazole which are often used together in a singular capsule. Aspirin is a common drug for relieving minor aches, pains, and fevers. People also use it as an anti-inflammatory or a blood thinner. Because of its regular and continuous usage, it may cause peptic ulcers. Peptic ulcers are open sores that develop on the inside lining of your stomach and the upper portion of your small intestine which can be uncomfortable and painful. Consequently, people with ulcers resort to omeprazole to treat them...
Arum palaestenium in cancer therapies
Cancer is a very complicated sequence of disease conditions progressing gradually with a generalized loss of growth control.1–3 There were only a few options of cancer treatment for patients for many decades which include surgery, radiation therapy, and chemotherapy as single treatments or in combination.4,5 But recently, many pathways involved in cancer therapy progression and how they can be targeted has improved dramatically, with combinatorial strategies, involving multiple targeted therapies or “traditional” chemotherapeutics, such as the taxanes and platinum compounds, being found to have a synergistic effect.6 New approaches, such as drugs, biological molecules, and immune-mediated therapies, are being used for treatment.
Artrite reumatoide e spondiloentesoartriti : Diagnostica per immagini e imaging follow-up = Rheumatoid Arthritis and Spondyloentesoarthritis : Follow-up imaging and imaging
Recent technological evolutions in diagnostic imaging have allowed him to grasp the anatomical and functional alterations that characterize the onset phase of degenerative and inflammatory arthropathies. In the context of the latter, in particular, imaging is not only fundamental in the diagnosis of the early stage of arthritis but also in defining their evolution and response to modern therapeutic treatment. The evaluation of a new imaging semeiology, which makes considerable use of the use of contrast medium in relation to both power Doppler and magnetic resonance imaging, has made it possible to narrow the gap between histology and imaging in rheumatological diagnostics.
Artificial intelligence in drug design
Looks at applications of artificial intelligence (AI), machine learning (ML), and deep learning (DL) in drug design. The chapters in this book describe how AI/ML/DL approaches can be applied to accelerate and revolutionize traditional drug design approaches such as: structure- and ligand-based, augmented and multi-objective de novo drug design, SAR and big data analysis, prediction of binding/activity, ADMET, pharmacokinetics and drug-target residence time, precision medicine and selection of favorable chemical synthetic routes. How broadly are these approaches applied and where do they maximally impact productivity today and potentially in the near future.
Artificial intelligence based cancer nanomedicine : Diagnostics, therapeutics and bioethics
Nanomedicine is evolving with novel drug formulations devised for multifunctional approaches towards diagnostics ad therapeutics. Nanomedicine-based drug therapy is normally explored at a fixed dose. The drug action is time-dependent, dose-dependent and patient-specific. To overcome challenges of nanomedicine testing, artificial intelligence (AI) serves as a helping tool for optimizing the drug and dose parameters. Real time conversions between these two features enables upgradation of patient data acquisition and improved design of nanomaterials. In this scenario, AI-based pattern analysis and algorithms models can greatly improve accuracy of diagnostics and therapeutics.
Artificial intelligence : The revolution of drug discovery
The successful application of AI is dependent on the availability of high-quality data, the addressing of ethical concerns, and the recognition of the limitations of AI-based approaches. Moreover artificial intelligence has been a game changer in the past decade. AI proved his worth by making the impossible possible in a short period of time. The health care industry has adopted artificial intelligence technology to deal with the ever-changing therapeutic and drug requirements of patients every day, as we encounter new viruses for which no antidote has been prepared, such as the Corona virus, diseases such as malaria, and the most important problem is the resistance to antibiotics by superbugs that are constantly developing new resistance mechanisms causing harm and confusion.
