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CADD and informatics in drug discovery
Updates knowledge on recent advances in computational and bioinformatics tools/techniques and their practical applications in modern drug design and discovery programme. Also it encompasses fundamental principles, advanced methodologies and applications of various CADD approaches including several cutting-edge areas / presenting recent developments covering ongoing trends in the field of computer-aided drug discovery. Having contributions by a global team of experts, the book is expected to be an ideal resource for drug discovery scientists, medicinal chemists, pharmacologists, toxicologists, phytochemists, biochemists, biologists, RandD personnel, researchers, students, teachers and those working in the field of drug discovery. It will fill the knowledge gaps that exist in the current CADD approaches and methodologies/ protocols being widely used in both academic and research practices. Further, a special focus on current status of various computational drug design approaches (SBDD, LBDD, De-novo drug design, Pharmacophore-based search), bioinformatics tools and databases, computational screening and modeling of phytochemicals/natural products, artificial intelligence and machine learning, and network pharmacology and system biology would certainly guide researchers, students or readers to conduct their research in the emerging area(s) of interest. It is also expected to be highly beneficial to different stakeholders working in the pharmaceutical and biotechnology industries (RandD), the academic as well as research sectors. .
Business Plan: Telepherique Du Bludan
Telepherique Du Bludan is one of the most prominent tourist attractions that targets tourists and visitors from all over the world and it’s a unique and unconventional experience. Bludan area has a strategic location and we should give it more spotlights since it has a wonderful weather in the winter and in the summer, In order to stimulate domestic tourism, we have implemented a project to construct a cable car in the Bludan area in an entertainment complex, and this is something that does not exist in Syria and encourages tourism in the winter to transport people to heights for the possibility of enjoying snow and practicing snow activities, and in summer it can be used to transport people to the top of the height and get a beautiful view in great weather And enjoyment in outdoor activities that are not found in Syria, and this adds a competitive advantage to our project.
Buildings for Education: A Multidisciplinary Overview of The Design of School Buildings
This book presents theoretical and practical research relating to the vast, publicly financed program for the construction of new schools and the reorganization of existing educational buildings in Italy.
Building codes illustrated : A guide to understanding the 2018 International Building Code ; 6th ed.
Provides brand new chapters on plumbing fixture counts, elevators, special construction, and existing buildings while updating the remainder of the material to align with recent changes to the IBC. includes: Thorough introductions to navigating the Code, use and occupancy, special uses and occupancies, and building heights and areas / Full explorations of the types of construction, fire resistive construction, interior finishes, fire-protection systems, and means of egress / Practical discussions of accessibility, interior environment, exterior walls, roof assemblies, and structural provisions / In-depth examinations of special inspections and tests, soils and foundations, building materials and systems, and elevators
Broadband Fixed Wireless Access : A System Perspective
Broadband Fixed Wireless Access provides a systematic overview of the emerging WiMax technology, and much of the material is based on the practical experiences of the authors in building broadband wireless systems. This material will be of significant interest to network architects and developers of broadband fixed wireless access products. With the adoption of the IEEE 802.16 standard and the advent of next generation equipment, the WiMax technology has been growing in interest. The authors discuss applications at microwave frequencies between 2 and 11 GHz that could be attractive options for operators without an existing access infrastructure for reaching end users with broadband services. This introductory volume demystifies the technology and provides technical exposure to the various system trade-offs. Additionally.
Blockchain and crypto currency : Building a high quality marketplace for crypto data
This book contributes to the creation of a cyber ecosystem supported by blockchain technology in which technology and people can coexist in harmony. Blockchains have shown that trusted records, or ledgers, of permanent data can be stored on the Internet in a decentralized manner.
Bird species : How they arise, modify and vanish
The average person can name more bird species than they think, but do we really know what a bird “species” is? This open access book takes up several fascinating aspects of bird life to elucidate this basic concept in biology. From genetic and physiological basics to the phenomena of bird song and bird migration, it analyzes various interactions of birds – with their environment and other birds. Lastly, it shows imminent threats to birds in the Anthropocene, the era of global human impact.This book brings together various disciplines involved in observing bird species come into existence, modify, and vanish. It is a rich resource for bird enthusiasts who want to understand various processes at the cutting edge of current research in more detail. At the same time it offers students the opportunity to see primarily unconnected, but booming big-data approaches such as genomics and biogeography meet in a topic of broad interest. Lastly, the book enables conservationists to better understand the uncertainties surrounding “species” as entities of protection.
Bioactive and therapeutic dental materials
Special attention has been given to bioactive materials developed to induce cells differentiation/stimulation, hard tissue formation and exert antimicrobial actions. New innovations are necessary to continue to help reinforcing existing technologies and to introduce new paradigms for treating dental disease and restoring teeth seriously compromised by caries lesions via biomimetic and more biological operative approaches. Dental bioactive materials is arguably the latest research area in dentistry and thus the amount of new research is overwhelming. However, in this day and age of evidence based practice it important for this new information to be distilled into a practical and understandable format.
Bilinear integrable systems : From classical to quantum, continuous to discrete ; Proceedings of the NATO Advanced Research Workshop on Bilinear Integrable Systems: From Classical to Quantum, Continuous to Discrete St. Petersburg, Russia, 15-19 September 2002
Trained as a physicistin his home university Kyushu University, Professor Hirota earned his PhD in’61 at Northwestern University with Professor Siegert in the field of “QuantumStatistical mechanics”. He wrote a widely appreciated Doctoral dissertation on“Functional Integral representation of the grand partition function”. As a youngresearcher, he entered the RCA Company in Tokyo to do research on semi-conductor plasmas. Professor Hirota was led to model the Toda lattice as a non-linear networkof ladder-type LC circuits. The self-dual case led to equations very reminiscentof the Sine-Gordon equation, with much the same features (existence of onesoliton, soliton-soliton interaction, etc)
Bidding Strategies in Agent-Based Continuous Double Auctions
Presents a new bidding strategy for agents to adopt in CDAs and propose tools to enhance the performance of existing bidding strategies in CDAs. The superior performance of the new bidding strategy as well as the tools presented in this book are illustrated through extensive experiments.
Becoming virtual : Knowledge management and transformation of the distributed organization
This book examines the capabilities needed to transform a globally distributed organization into a virtual organization (an organization that exists and operates across time and distance with the support of global communications technologies such as the Internet). It introduces techniques for definition of goals for virtualization, for monitoring progress toward virtualization and for studying the impact of virtualization on social uncertainty, knowledge sharing and knowledge transfer, organizational memory, transactive memory, communities of practice and organizational commitment, power and control. These techniques are applied in an extended case study of a development aid organization's attempts to use knowledge management for virtualization over a two year period. The multidisciplinary team of authors examines virtualization from points of view ranging from the organizational to the technological to the sociological and psychological.
Beauty’s Appeal : Measure and Excess
Beauty fulfils human existence. As it registers in our aesthetic experience, beauty enhances nature’s enchantment around us and our inward experience lifting our soul toward moral elevation. Carried by creative imagination (Imaginatio Creatrix), beauty participates in the moulding of the forms of the intellective constitution of the mind in tandem with praxis and seeks deeper enigmas of the real in the labyrinth of the cosmos. Yet with the evolution of human development and in technological inventions, beauty, while suffusing all modalities of experience, seems to undergo transformations and expansion. Are there perduring norms and modalities of beauty or are we carried along blindly by human development? Is there a measure intrinsic to our human ontopoietic unfolding and the growth of human life that we may follow instead of the whim of fancy and excess? The present collection of art-explorations seeks the elemental ties of Human Condition. Together, the authors aim to answer the questions posed above.
Barcelona : urban architecture and community since 2010
Highlights some of the most exciting structures built in Barcelona since 2010, bringing readers on a guided tour of surprising residential buildings, intriguing museums and extraordinary community spaces. The projects, including many additions to existing buildings, are documented with photos, floor plans and texts. Supplementary interviews introduce readers to key players in Barcelona’s architectural scene, while essays shed light on little-known aspects of the city’s urban development and transport planning.
Balkan Sprachbund Morpho-Syntactic Features
This book discusses the morpho-syntactic Balkan Sprachbund features in nine languages in which they are most numerous. It contains a wealth of Balkan linguistic material, collected from both the existing literature sources and from the author’s own field work.
Autonomous vehicles technological trends
The automotive industry has always been synonymous with research and innovation, but nowadays the industry is adding pressure and is establishing the agenda of the researchers from the field. Visions have been provided, and the hardware and the software exist; the only question remaining is: “who is going to deliver”? To answer this question, we encouraged scientists, researchers, industry specialists, and academics to share their vision of autonomous vehicles. What will the platform look like? What kind of hardware and software is most suitable? Who will make the connection between these two interdependent environments (and how), so that in the end the AI will define the process? These are the pressing issues of the current moment, and this Special Issue will help all those interested in the topic to promote their vision and ideas.
Autonomous intelligent systems : Multi-agents and data mining ; 2nd International workshop, AIS-ADM 2007, St. Petersburg, Russia, June 3-5, 2007, Proceedings
MAS offiers powerful metaphors for information system conceptualization, a range of new techniques, and technologies specifically focused on the design and implementation of lar- scale open distributed intelligent systems. KDD also provides intelligent inf- mation technology with powerful ideas, algorithms, and software means to help cope with the main problem of artificial intelligence, formulated in the we- known question “Where does the knowledge come from?”, thus actually making modern applications intelligent and adaptive. The evident recent trend in both science and industry is to integrate and take advantage of both technologies. The existing experience with combined application of multi-agent technology to design architectures of distributed (- erarchical and peer-to-peer) data mining and KDD systems, as well as the u- lization of data mining and KDD achievements to provide enhanced intelligence of MAS, confirms the fact that both technologies are capable of mutual enri- ment and their integrateduse may result in intelligent information systems with new emergent properties.
Automatic Quantum Computer Programming : A Genetic Programming Approach
Computer science will be radically transformed if ongoing efforts to build large-scale quantum computers eventually succeed and if the properties of these computers meet optimistic expectations. Nevertheless, computer scientists still lack a thorough understanding of the power of quantum computing, and it is not always clear how best to utilize the power that it is understood. This dilemma exists because quantum algorithms are difficult to grasp and even more difficult to write. Despite large-scale international efforts, only a few important quantum algorithms are documented, leaving many essential questions about the potential of quantum algorithms unanswered.
Automated machine learning : Methods, systems, challenges
This book presents the first comprehensive overview of general methods in Automated Machine Learning (AutoML), collects descriptions of existing systems based on these methods, and discusses the first series of international challenges of AutoML systems. The recent success of commercial ML applications and the rapid growth of the field has created a high demand for off-the-shelf ML methods that can be used easily and without expert knowledge. However, many of the recent machine learning successes crucially rely on human experts, who manually select appropriate ML architectures (deep learning architectures or more traditional ML workflows) and their hyperparameters. To overcome this problem, the field of AutoML targets a progressive automation of machine learning, based on principles from optimization and machine learning itself.
Auditory Perception of Sound Sources
Auditory Perception of Sound Sources covers higher-level auditory processes that are perceptual processes. The chapters describe how humans and other animals perceive the sounds that they receive from the many sound sources existing in the world. This book will provide an overview of areas of current research involved with understanding how sound-source determination processes operate. This book will focus on psychophysics and perception as well as being relevant to basic auditory research.
Atlas of Sarcoidosis : Pathogenesis, Diagnosis and Clinical Features
An Atlas of Sarcoidosis: Pathogenesis, Diagnosis and Clinical Features combines illustrations and clinical images of the authors' extensive practices, so that readers have unparalleled access to a comprehensive collection of sarcoidosis images. The atlas is designed to complement and provide a visual supplement to already existing texts on sarcoidosis. Each organ involvement is dealt in a brief and easy to comprehend manner. Various radiographic and laboratory abnormalities are then linked to the clinical features in order to encourage a smooth and easy practical integration at the bedside and to help practising pulmonologists, dermatologists and other clinicians who require a comprehensive visual encyclopedia of sarcoidosis images.
