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Ion channels as targets in drug discovery
Built around ion channel research and, more specifically, ion channels as important therapeutic drug targets. Under the editorial leadership of Gary Stephens in academic research and Edward Stevens from industry, the aim is to bring these strands together to provide a cutting-edge translational reference on ion channel drug discovery. Exploiting our knowledge of ion channel structure and function has clear current and future potential to intervene and correct the pathophysiology associated with debilitating conditions, including cardiovascular disease, diabetes, cystic fibrosis, pain, epilepsy, and neurodegenerative disorders. Individual chapters have a disease focus, also providing a “case study story” that will also appeal to a clinical audience
Invited Lectures from the 13th International Congress on Mathematical Education
The book presents the Invited Lectures given at 13th International Congress on Mathematical Education (ICME-13). The papers present the work of prominent mathematics educators from all over the globe and give insight into the current discussion in mathematics education. The Invited Lectures cover a wide spectrum of topics, themes and issues and aim to give direction to future research towards educational improvement in the teaching and learning of mathematics education. This book is of particular interest to researchers, teachers and curriculum developers in mathematics education.
Investigating Spoken English : A Practical Guide to Phonetics and Phonology Using Praat
Combining coverage of the key concepts and tools within phonetics and phonology with a systematic introduction to Praat, this textbook provides a lively and engaging 'way in' to the discipline. The author first covers the fundamentals of the articulatory and acoustic aspects of speech and introduces Praat as the main tool for examining and visualising speech. Next, the unit of analysis is gradually expanded (from syllables to words to turns and dialogues) and excerpts of real dialogues exemplify the core concepts for discovering how speech works.
Intrusion and Malware Detection and Vulnerability Assessment 2nd International Conference, DIMVA 2005, Vienna, Austria, July 7-8, 2005, Proceedings
Represents an increase of approximately 25% compared with the n- ber of submissions last year. All submissions were carefully reviewed by at least three Program Committee members or external experts according to the cri- ria of scienti?c novelty, importance to the ?eld, and technical quality. The ?nal selection took place at a meeting held on March 18, 2005, in Zurich, Switz- land. Fourteen full papers were selected for presentation and publication in the conference proceedings. In addition, three papers were selected for presentation in the industry track of the conference. The program featured both theoretical and practical research results, which were grouped into six sessions. Philip Att?eld from the Northwest Security Institute gave the opening keynote speech. The slides presented by the authors are available on the DIMVA 2005 Web site at http://www.dimva.org/dimva2005 We sincerely thank all those who submitted papers as well as the Program Committee members and the external reviewers for their valuable contributions.
Introduction to Variance Estimation
The book provides instruction on the methods that are vital to data-driven decision making in business, government, and academe. It will appeal to survey statisticians and other scientists engaged in the planning and conduct of survey research, and to those analyzing survey data and charged with extracting compelling information from such data. It will appeal to graduate students and university faculty who are focused on the development of new theory and methods and on the evaluation of alternative methods. Software developers concerned with creating the computer tools necessary to enable sound decision-making will find it essential.
Introduction to the theory of computation
Gain a solid understanding of the fundamental mathematical properties of computer hardware, software, and applications with a blend of practical and philosophical coverage and mathematical treatments, including advanced theorems and proofs.
Introduction to software design with Java
Provides an in-depth introduction to software design, with a focus on object-oriented design, and using the Java programming language. Its goal is to help readers learn software design by discovering the experience of the design process. To this end, the text follows a continuous narrative that introduces each element of design know-how in context, and explores alternative solutions in that context. This narrative is complemented by hundreds of code fragments and design diagrams.
Introduction to Scientific Programming with Python
This book offers an initial introduction to programming for scientific and computational applications using the Python programming language. The presentation style is compact and example-based, making it suitable for students and researchers with little or no prior experience in programming.
Introduction to robotics : Mechanics and control ; 3rd ed.
Includes material from traditional mechanical engineering, control theoretical material and computer science. It includes coverage of rigid-body transformations and forward and inverse positional kinematics
Introduction to robotics : Mechanics and control ; 2nd ed.
Written for senior level or first year graduate level robotics courses, this text includes material from traditional mechanical engineering, control theoretical material and computer science. It includes coverage of rigid-body transformations and forward and inverse positional kinematics
Introduction to Reconfigurable Computing : Architectures, Algorithms, and Applications
“Introduction to Reconfigurable Computing” provides a comprehensive study of the field Reconfigurable Computing. It provides an entry point to the novice willing to move in the research field reconfigurable computing, FPGA and system on programmable chip design. The book can also be used as teaching reference for a graduate course in computer engineering, or as reference to advance electrical and computer engineers. It provides a very strong theoretical and practical background to the field of reconfigurable computing, from the early Estrin’s machine to the very modern architecture like coarse-grained reconfigurable device and the embedded logic devices.
Introduction to Programming with Fortran : with coverage of Fortran 90, 95, 2003 and 77
Introduction to Programming with Fortran contains: lots of clear and simple examples highlighting the key language features of the most recent versions of Fortran – Fortran 2003, 95 and 90. practical examples based on ISO TR 15580 and ISO TR 15581 which are widely supported and cover the ISO TR on Enhanced Modules – particularly important to large code suites common problems that occur when programming which are highlighted via clear examples and solutions Introduction to Programming with Fortran is an essential introduction for beginners as well as a concise reference for professionals. Overall the book gives a very effective hands-on coverage of Fortran, valuable to students and practitioners alike.
Introduction to organic and medicinal chemistry
Designed to be an undergraduate reference textbook for students of chemistry who aim to select degree modules geared towards medicinal chemistry. The first two chapters offer an overview of basic organic chemistry, followed by organic synthesis in Chapter 3, with an emphasis on the importance of synthetic procedures in relation to the chemistry of drug design. In Chapter 4, the book covers foundational aspects of biochemistry and biomedical science to provide a basis for students understanding where and how drugs work on selected targets. Later, the book explains how medicines have been created for selected topics in medicinal chemistry – namely against pathogens, cancer and neurological targets.
Introduction to Optics
Since the discovery of the laser in 1960 and optical fibers in 1970, optics has undergone dramatic changes that accentuate its multi-disciplinary character. This text covers essential concepts and reports the key developments and progress in current knowledge in the field. Inspired by the style of Richard Feynman, the method of presentation emphasizes "telling" optics, rather than deducing it from fundamental laws, as well as tactfully using mathematical tools so as not to obscure the physical phenomena of interest. For its excellent teaching approach, the book received the Arnulf-Francon Award of the French Optical Society. The concepts are formulated in a way such that the necessary mathematical tools do not hinder comprehension of the phenomena. Global in vision, the book can also be used as a reference. In addition to the traditional aspects of optics, it includes the tools and methods currently used by researchers and engineers, as well as explanation and implications of the most recent developments.
Introduction to Operating System Design and Implementation : The OSP 2 Approach
This book exposes students to many essential features of operating systems while at the same time isolating them from low-level, machine-dependent concerns. With its accompanying software, the book contains enough projects for up to three semesters.
Introduction to Nursing Informatics
In the series, eminent experts, as editors or authors, offer their accounts of innovations in health informatics. Increasingly, these accounts go beyond hardware and software toaddresstheroleofinformationinin?uencingthetransformationofheal- caredeliverysystemsaroundtheworld.Theseriesalsowillincreasinglyfocus on “peopleware” and the organizational, behavioral, and societal changes that accompany the diffusion of information technology in health services environments.
Introduction to Lie Algebras
This book provides an elementary introduction to Lie algebras. It starts with basic concepts. A section on low-dimensional Lie algebras provides readers with experience of some useful examples. This is followed by a discussion of solvable Lie algebras and a strategy towards a classification of finite-dimensional complex Lie algebras. The next chapters cover Engel's theorem, Lie's theorem and Cartan's criteria and introduce some representation theory. The root-space decomposition of a semisimple Lie algebra is discussed, and the classical Lie algebras studied in detail. The authors also classify root systems, and give an outline of Serre's construction of complex semisimple Lie algebras. An overview of further directions then concludes the book and shows the high degree to which Lie algebras influence present-day mathematics.The only prerequisite is some linear algebra and an appendix summarizes the main facts that are needed. The treatment is kept as simple as possible with no attempt at full generality.
Introduction to Geometric Computing
The geometric ideas in computer science, mathematics, engineering, and physics have considerable overlap and students in each of these disciplines will eventually encounter geometric computing problems. The topic is traditionally taught in mathematics departments via geometry courses, and in computer science through computer graphics modules. This text isolates the fundamental topics affecting these disciplines and lies at the intersection of classical geometry and modern computing.
Introduction to Focused Ion Beams : Instrumentation, Theory, Techniques and Practice
Introduction to Focused Ion Beams is geared towards techniques and applications. The first portion of this book introduces the basics of FIB instrumentation, milling, and deposition capabilities. The chapter dedicated to ion-solid interactions is presented so that the FIB user can understand which parameters will influence FIB milling behavior. The remainder of the book focuses on how to prepare and analyze samples using FIB and related tools, and presents specific applications and techniques of the uses of FIB milling, deposition, and dual platform techniques. This is the only text that discusses and presents the theory directly related to applications and the only one that discusses the vast applications and techniques used in FIBs and Dual platform instruments.
