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Basis and Treatment of Cardiac Arrhythmias
Incorporating the information related to mechanisms and treatment of cardiac arrhythmia, this book discusses genetics of arrhythmias, cell signalling molecules as potential therapeutic targets and trafficking to the membrane. These approaches and implementations of anti-arrhythmic therapy derive from many decades of research.
Basic Science Techniques in Clinical Practice
Medical researchers including doctors, nurses, medical students and allied health professionals are required to undertake a period of research as part of their career pathway. Basic Science Techniques in Clinical Practice covers the main areas, allowing anyone to set up and complete research projects and this information can easily be translated to clinical projects. Written by international authors to provide a flavor from many institutions, the book’s appeal is cross-sectional, both at hospital and primary care levels worldwide.
Basic & Clinical Biostatistics
Provides medical students, researchers, and practitioners with the knowledge needed to develop sound judgment about data applicable to clinical care. This fifth edition has been updated throughout to deliver a comprehensive, timely introduction to biostatistics and epidemiology as applied to medicine, clinical practice, and research. Particular emphasis is on study design and interpretation of results of research.
Barriers and Biases in Computer-Mediated Knowledge Communication : And How They May Be Overcome
This books deals with computer-mediated cooperation and communication scenarios in teaching and learning situations, leisure activities (e.g. laypersons looking for expert information on the internet), and net-based communication at work. Such scenarios will become increasingly important. But the successful use of such computer-mediated settings is not trivial. Cooperative learning and work itself requires special skills and strategies. And the technical settings with sometimes restricted, sometimes new possibilities for communication add problems on top of the cooperation itself. What are the barriers in computer-mediated communication for cooperative learning and work? Which are the most relevant biases in computer-mediated information processing? Based on empirical research the contributors from psychology, education and computer sciences offer different perspectives on the nature and causes of such barriers.
Balancing Exploration and Exploitation by Creating Organizational Think Tanks
Key for successful knowledge management is a balance between exploration and exploitation. Danger arises when exploration is neglected in favour of exploitation since that may result in an organization which lacks innovation capability. In order to prevent this, an idea has been put forward in recent knowledge management research called ambidexterity, which means the simultaneous and balanced pursuing of both exploration and exploitations activities. Tatjana-Xenia Puhan follows up on this idea by concluding that ambidexterity need not necessarily be implemented in one single organization but can also be realised in a network of associated organizations. The interorganizational ambidexterity is based on co-specialisation: one organisation is devoted solely to exploration while associated organizations focus on their competences in exploitation. Furthermore, the author develops the concept of think tanks as organizations that concentrate on radical innovations while their network associates exploit this newly generated knowledge commercially.
Bacteriophage therapy : a potential solution for antibiotic resistance crisis
For many years, humans have been fighting with bacteria, in a matter of fact, bacteria have been winning for the last decade, becoming resistant to every weapon we have; The antibiotics. In order to win the fight humans had to think of alternative ways, like viruses. There is a special type of viruses that have been in a war with bacteria for millenniums, Bacteriophages. Bacteriophages (or phages), the most abundant viral entity of the planet. On the basis of their unique characteristics and anti-bacterial property, phages are being the freshly evaluated taxonomically. Phages replicate inside the host either by lytic or lysogenic mode after infecting and using the cellular machinery of a bacterium. Phage became an important agent for combating pathogenic bacteria in clinical treatments and its related research gained momentum. However, due to recent rise of bacterial resistance on antibiotics, applications of phage (phage therapy) become an unavoidable option of research. In this dissertation, the advantage and limitations of Bacteriophages for use in humans will be discussed. Furthermore, this dissertation deals with recent development of its application in the areas of biotechnology.
Bacterial signal transduction : Networks and drug targets
Interactions among different TCSs enable one system to respond to multiple signals, which is important for bacteria to minutely adjust themselves to complex environmental changes. Such interactions are found or predicted in various bacteria in this book. Over the past decade, a vast amount of exciting new information on the signal transduction pathway in bacteria has been brought to light. Reports on these develop› ments have been put together in this book, Bacterial Signal Transduction: Networks andDrug Targets. This book Offers an incentive for graduate students, academic scientists, and researchers in the pharmaceutical industry to further elucidate the TCS networks and apply them in the search for novel drugs.
Bacterial secretion systems : Methods and protocols
Cover techniques used to study secretion systems. Chapters focus on identifying and localizing the different subunits, defining interactions within subunits, monitoring conformational changes, purifying and imaging of large complexes, defining the assembly pathway by fluorescence microscopy and the role of energy during assembly and/or secretion, identifying secreted effectors as well as using reporters to follow effector transport. Written in the highly
Bacterial resistance to disinfectants
Bacterial resistance to disinfection is an escalating concern within healthcare facilities, as it poses a significant threat to patient safety and infection control. This research paper aims to explore the various mechanisms underlying bacterial resistance to disinfection, including intrinsic and acquired resistance, as well as the phenomenon of cross-resistance to antibiotic which poses a serious threat worldwide...
Bacterial Biofilms
This volume tends to focus on the biology of biofilms that affect human disease. It opens with chapters that provide the reader with current perspectives on biofilm development, physiology, environmental and regulatory effects, the role of quorum sensing, and resistance/phenotypic persistence to antimicrobial agents during biofilm growth. The next chapters are devoted to common problematic biofilms, those that colonize venous and urinary catheters. The final series of chapters examines biofilm formation by four species that are important pathogens and well studied models, one of which, Yersinia pestis, cleverly adopts a biofilm state of growth within its insect vector to promote disease transmission to mammalian hosts.
Axon growth and guidance
The complexarchitectureofneuronal networks togetherwith the extraordinary associated functions make the nervous system a fascinating biological structure. The considerable work performed to explore this cellular machinery is nowadays successfulbecause the mysteryofnervous system developmentisbeing unravelled. As described in their outstanding review published 10 years ago in Science.' Marc Tessier-Lavigne and Corey Goodman-the pioneers of the molecular era of axon guidance-summarized the assembly of nervous system connections as a subtle game of attraction and repulsion of neuronal growth cones. The cellular ballet ensuring the formation of billions of synapses, which ultimately gives rise to the highest cognitive functions, is primarily orchestrated by a step-by-step mechanism of growth driven by multiple molecular cues. While our general concept of axon guidance remains identical, a profound evolution ofour knowledge ofthe molecular identityofthe guidance cues together with their interactions and signalling pathways occurred over the past ten years.
Axial flux permanent magnet brushless machines
This book deals with the analysis, construction, design, control and applications of AFPM machines. The authors present their own research results, as well as significant research contributions made by others.
Axial flux permanent magnet brushless machines
Axial Flux Permanent Magnet (AFPM) brushless machines are modern electrical machines with a lot of advantageous merits over their conventional counterparts. They are increasingly used in power generation, domestic appliances, industrial drives, electric vehicles, and marine propulsion drives and many other applications. This book deals with the analysis, construction, design, optimisation, control and applications of AFPM machines. The authors present their own research results, as well as significant research contributions made by others. This monograph will be of interest to electrical engineers and other engineers involved in the design and application of AFPM brushless machine drives. It will be an important resource for researchers and graduate students in the field of electrical machine and drives.
Aviation Noise Impact Management : Technologies, Regulations, and Societal Well-being in Europe
This book provides a view into the state-of-the-art research on aviation noise and related annoyance. The book will primarily focus on the achievements of the ANIMA project (Aviation Noise Impact Management through Novel Approaches), but not exclusively.
Average-Cost Control of Stochastic Manufacturing Systems
This book is concerned with hierarchical control of manufacturing systems under uncertainty. It focuses on system performance measured in long-run average cost criteria, exploring the relationship between control problems with a discounted cost and that with a long-run average cost in connection with hierarchical control. A new theory is articulated that shows that hierarchical decision making in the context of a goal-seeking manufacturing system can lead to a near optimization of its objective. The approach in the book considers manufacturing systems in which events occur at different time scales.
Avalanche Dynamics : Dynamics of Rapid Flows of Dense Granular Avalanches
Avalanches, debris, mudflows and landslides are common and natural phenomena that occur worldwide, predominantly in mountainous regions. With an emphasis on snow avalanches, this book sets out to provide a survey and discussion about the motion of avalanche-like flows from initiation to run out. An important aspect of this book is the formulation and investigation of a simple but appropriate continuum mechanical model for the realistic prediction of geophysical flows of granular material. This will help the practitioners in the field to better understand the physical input and provide them with a tool for their work. Originating from many lectures the authors have given over the years, this instructive volume brings the reader to the forefront of research - an aim also supported by an extensive bibliogrpahy of almost 500 entries.
Autonomy oriented computing : From problem solving to complex systems modeling
Autonomy Oriented Computing explores the important theoretical and practical issues in AOC, by analyzing methodologies and presenting experimental case studies. The book serves as a comprehensive reference source for researchers, scientists, engineers, and professionals in all fields concerned with this promising new development in computer science. It can also be used as a main or supplementary text in graduate and undergraduate programs across a broad range of computer-related disciplines, including Robotics and Automation, Amorphous Computing, Image Processing and Computer Vision, Programming Paradigms, Computational Biology, and many others. The first part of the book, Fundamentals, describes the basic concepts and characteristics of an AOC system, and then it enumerates the critical design and engineering issues faced in AOC system development. The second part of the book, AOC in Depth, provides a detailed analysis of methodologies and case studies to evaluate the use of AOC in problem solving and complex system modeling. The final chapter reviews the essential features of the AOC paradigm and outlines a number of possibilities for future research and development.
Autonomy and human rights in health care : An international perspective
Autonomy and Human Rights in Healthcare: An International Perspective is a group of essays published in memory of David Thomasma, one of the leading humanists in the field of bioethics during the twentieth century. A pioneer in the field of multidisciplinary research, having integrated major theological and philosophical traditions in the west with modern science, Thomasma was a role model to the authors who have devoted essays to his major avenues of inquiry. The authors represent many different countries and disciplines throughout the globe. The volume deals with the pressing issue of how to ground a universal bioethics in the context of the conflicted world of combative cultures and perspectives.
Autonomous vehicles technological trends
The automotive industry has always been synonymous with research and innovation, but nowadays the industry is adding pressure and is establishing the agenda of the researchers from the field. Visions have been provided, and the hardware and the software exist; the only question remaining is: “who is going to deliver”? To answer this question, we encouraged scientists, researchers, industry specialists, and academics to share their vision of autonomous vehicles. What will the platform look like? What kind of hardware and software is most suitable? Who will make the connection between these two interdependent environments (and how), so that in the end the AI will define the process? These are the pressing issues of the current moment, and this Special Issue will help all those interested in the topic to promote their vision and ideas.
Autonomous Systems - Self-Organization, Management, and Contro ; Proceedings of the 8th International Workshop held at Shanghai Jiao Tong University, Shanghai, China, October 6–7, 2008
The International Workshop on "Autonomous Systems - Self-Organization, Management, and Control " is the eighth in a successful series of workshops that were established by Shanghai Jiao Tong University and Technische Universitat Berlin. The goal of these workshops is to bring together researchers from both universities in order to present research results to an international community.
