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Genomic Disorders : The Genomic Basis of Disease
In Genomic Disorders: The Genomic Basis of Disease, distinguished experts and pioneers in the field of genomics and genome rearrangements summarize and synthesize the tremendous amount of data now available in the postgenomic era on the structural features, architecture, and evolution of the human genome.
Genome editing in neurosciences
Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technology, which has the precision and scalability to tackle the complexity of the brain. This Colloque Médecine et Recherche has brought together experts from around the world that are applying genome editing to address important challenges in neuroscience, including basic biology in model organisms that has the power to reveal systems-level insight into how the nervous system develops and functions as well as research focused on understanding and treating human neurological disorders.
Genome Editing : Gene Therapy or Gene Optimization?
Genome editing technology is considered one of the most revolutionary techniques lately. The ability of modifying the human genome has been one of the biggest dreams for therapist for the reason that the genetic modification with exogenous DNA can be considered a problem solver for many diseases and disorders (genetic disorders), especially those with high risks and low survival rates, on this case, gene therapy appears as the tool to be used, with its many protocols and approaches. Gene therapy is based on delivering a therapeutic gene throw suitable vectors, which is most of the time-modified viruses to carry the therapeutic genes to the target cells and so on providing the functional copy of the defective gene.
Genetic testing in reproductive medicine
Illustrates the importance and significance of molecular genetic testing in reproductive disorders. The present book covers the genetic testing in various reproductive system anomalies, including disorders of sexual development, male infertility (Y deletions, autosomal mutations, sperm DNA fragmentation), female infertility (PCOS and POF), mitochondrial DNA testing for oocyte quality, recurrent pregnancy loss, pre-term birth, endometrial receptivity, prenatal genetic screening, reproductive carrier screening, preimplantation genetic screening, endometrial cancer, cervical cancer and other related reproductive health disorders. Microbiome testing and its contribution to genetic testing in reproductive medicine are also discussed. Covers ethical, moral and technical challenges in genetic testing in reproductive medicine. The book aims to set up a standard with regard to genetic testing in the reproductive medicine field, encourage further data generation, and provide food for thought in the areas of lacunae.
Genetic basis of oral health conditions
This book explains the genetic basis of a wide range of dental disorders, including dental caries, periodontitis, congenital anomalies, malocclusions, orofacial pain, dental implant failure, and cancer. The information provided in this book will assist in the delivery of effective personalized dental care through optimization of preventive strategies.
Genetic Basis for Respiratory Control Disorders
The objective of the book is to supply state-of-the-art contributions about all aspects of respiratory control genetics, from the molecular to the system level. The book aims to review the full spectrum of available knowledge, which starts with early physiological studies in health and disease in humans and studies in rodents that suggested a hereditary component to respiratory control. The spectrum extends to recent work elucidating crucial molecular aspects of respiratory control development, from early embryonic specifications in the neural tube to the function of respiratory rhythm generators.
Gastroesophageal reflux disease : Principles of disease, diagnosis, and treatment
Gastroesophageal reflux disease (GERD) is one of the most common disorders with an increasing prevalence and incidence in the last two decades. This book presents clinically relevant information for gastroenterologists, internists, surgeons, residents and also nurses, who frequently care for GERD patients.
Gastroesophageal reflux disease : From pathophysiology to treatment
Offers a state-of-the-art description of the pathophysiology, diagnosis and treatment of gastroesophageal reflux disease (GERD). Although GERD is one of the most common gastrointestinal disorders, its diagnosis and management are often challenging. Expert physicians provide an evidence- and experience-based analysis in each chapter.
Fundamentals of craniofacial malformations ; Vol.1 : Disease and diagnostics
Opens by considering general topics such as developmental biology and disease classification and then examines in depth the biological basis of the various malformations, including craniosynostoses, cleft-lip and palate with complex orofacial clefts, branchio-oculo-facial syndromes, rare syndromes, soft tissue malformations, and dysgnathia. Psychological aspects, including psychological evaluation methods and therapies and quality of life issues, are then addressed. Finally, all relevant clinical, radiological, and genetic investigations are described and important diagnostic issues are explored.
Fundamentals of anatomy and physiology of speech, language, and hearing
Each topic is explored in bullet-point form with augmentative paragraph information, in-depth box features, and detailed illustrations. High-resolution Anatomage virtual dissection table figures derived from real cadavers offer an unparalleled glimpse into the anatomical structures of the human body, featuring true-to-life colors and an impressive level of detail. Topics explored include respiration, phonation, articulation, swallowing, resonance, hearing, balance, neuroanatomy, and neurophysiology.
From Stochastic Calculus to Mathematical Finance : The Shiryaev Festschrift
The Festschrift is a collection of papers, including several surveys, written by his former students, co-authors and colleagues. These reflect the wide range of scientific interests of the teacher and his Moscow school. The topics range from the disorder problems to stochastic calculus and their applications to mathematical economics and finance. A full biobibliography of Shiryaev's works is included. The book represents the modern state of art of many aspects of a quickly maturing theory and will be an essential source and reading for researchers in this area.
From Melancholia to Depression : Disordered Mood in Nineteenth-Century Psychiatry
This book maps a crucial but neglected chapter in the history of psychiatry: how was melancholia transformed in the nineteenth century from traditional melancholy madness into a modern biomedical mood disorder
Frailty and Kidney Disease : A Practical Guide to Clinical Management
This book is of importance in nephrology, specifically nephrogeriatrics, since frailty is a condition affecting many elderly patients and which is becoming increasingly common in medical practice. As such, there is a considerable need for information to assist professionals treating these patients. The book includes chapters on the frailty syndrome (definition, evaluation and treatment), the main geriatric syndromes (gait disorder, falls, incontinence, and delirium), the main renal syndromes (acute renal injury, chronic kidney disease) as well as dialysis and kidney transplant, and the relationship between geriatrics and renal syndromes.
Forefoot Reconstruction
For a long time, forefoot surgery had many disadvantages including a painful postoperative period and recurrence of deformities. New techniques – notably Scarf, the first metatarsal osteotomy and the Weil osteotomy of the lesser metatarsal – provide a significant improvement in the treatment of static forefoot disorders. The great toe osteotomy has also been greatly improved. Since 1991, the author has introduced these techniques in many countries, while developing and studying the corresponding implants and the postoperative period. He has also developed surgical management techniques that bridge these different osteotomies. More than 1000 surgeons around the world are using these techniques, which are now widely taught. In this second edition of the book the general presentation is clearer and more pleasant and many pictures have been replaced. Several topics are emphasized, notably the great toe proximal phalanx osteotomy, the joint preservative surgery in severe forefoot disorders, including revision after failed bunionectomy and rheumatoid forefoot following the "ms” point for an accurate and effective metatarsal shortening. Lastly, new procedures are exposed, particularly in Claw toe and hammer with the PIP plantar release and the surgery of the middle phalanx and also the Weil osteotomy of the first metatarsal in hallux limitus.
Forces, Growth and Form in Soft Condensed Matter : At the Interface between Physics and Biology
This volume comprises the proceedings of a NATO Advanced Study Institute held at Geilo, Norway, 24 March - 3 April 2003, the seventeenth ASI in a series held every two years since 1971. The objective of this ASI was to identify and discuss areas where synergism between modern physics, soft condensed matter and biology might be most fruitful. The main pedagogical approach was to have lecturers focussing on basic understanding of important aspects of the relative role of the various interaction- electrostatic, hydrophobic, steric, conformational, van der Waals etc. Soft condensed matter and the connection between physics and biology have been the themes of several earlier Geilo Schools. A return to these subjects thus allowed a fresh look and a possibility for defining new directions for research. Examples of soft materials, which were discussed at this ASI, included colloidal dispersions, gels, biopolymers and charged polymer solutions, polyelectrolytes, protein/membrane complexes, nucleic acids and their complexes. Indeed, most forms of condensed matter are soft and these substances are composed of aggregates and macromolecules, with interactions that are too weak and complex to form crystals spontaneously. A characteristic feature is that small external forces, slight perturbations in temperature, pressure or concentration, can all be enough to induce significant structural changes. Thermal fluctuations are almost by definition strong in soft materials and entropy is a predominant determinant of structure, so that disorder, slow dynamics and plastic deformation are the rule. Hence the phrase ‘soft condensed matter’ has been coined.
Food addiction
This approach acknowledges the apparent parallels between substance use disorders and overeating of highly palatable, high-caloric foods. Although this idea seems to be relatively new, research on food addiction actually encompasses several decades, a fact that often remains unrecognized. Scientific use of the term addiction in reference to chocolate even dates back to the 19th century. In the 20th century, food addiction research underwent several paradigm shifts, which include changing foci on anorexia nervosa, bulimia nervosa, obesity, or binge eating disorder. Thus, the purpose of this review is to describe the history and state of the art of food addiction research and to demonstrate its development and refinement of definitions and methodologies
Food - drug interactions
The effect of drug on a person may be different than expected because that drug interacts with another drug the person is taking (drug-drug interaction), food, beverages, dietary supplements the person is consuming (drug-nutrient/food interaction) or another disease the person has (drug-disease interaction). A drug interaction is a situation in which a substance affects the activity of a drug, i.e. the effects are increased or decreased, or they produce a new effect that neither produces on its own. These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances. Regarding food-drug interactions physicians and pharmacists recognize that some foods and drugs, when taken simultaneously, can alter the body's ability to utilize a particular food or drug, or cause serious side effects.
Flow cytometry in hematopathology : A visual approach to data analysis and interpretation
Although instrumentation and laboratory techniques for flow cytometry (FCM) immunophenotyping of hematopoietic malignancies are well documented, there is relatively little information on how best to perform data analysis, a critical step in FCM testing. In Flow Cytometry in Hematopathology: A Visual Approach to Data Analysis and Interpretation, three physicians highly experienced in laboratory hematopathology and FCM offer a unique systematic approach to FCM data analysis and interpretation based on the visual inspection of dual parameter FCM graphics. This step-by-step approach to optimal FCM data analysis is demonstrated by means of numerous FCM graphics derived from actual well-documented clinical cases.The focus of the additional material is on the TCR-Vb eight-tube kit which has greatly facilitated the evaluation mature T-cell disorders, and on the DNA dye DRAQ5 for improved grading of malignant lymphoma. The authors also include notes on "tricks of the trade" and pitfalls to avoid. The discussion, covering leukemias, lymphomas, and other conditions, moves from simple to complex specimens, with an emphasis on visual pattern analysis.
Flavonoids as nutraceuticals
Flavonoids are well-known plant metabolites that have extraordinary properties that can be used for treating health issues. The pharmaceutical importance of flavonoids is due to their anti-depressant, anti-viral, anti-inflammatory, and antioxidant capacities. They are also of great importance when it comes to neuroprotection, cardiovascular disorders, and many types of cancer. Flavonoids are also easily available and produce less harmful side effects than some conventional therapeutics. This new volume examines the growing use of flavonoids for prevention and treatment of diseases and discusses their beneficial mechanisms. Chapters in the volume address diverse uses as anti-aging tools, as anti-inflammatory agents, for treating pregnancy-induced disorders, as a promising tool to combat infection of Covid-19, etc. The book explores their specific therapeutic antiviral potentials, the gene expression by flavonoids, and the role of flavonoids in agriculture.
Fishs clinical psychopathology : Signs and symptoms in psychiatry
The fifth edition of this modern classic presents the clinical descriptions and psychopathological insights for which this text is renowned, and adds suggested questions to assist with eliciting key symptoms. It also covers recent revisions of diagnostic classification systems, including the World Health Organization's ICD-11: International Classification of Diseases. Clear and readable, this new edition provides concise descriptions of the signs and symptoms of mental illness and astute accounts of the varied manifestations of disordered psychological function. Designed for use in clinical practice, this is an essential text for students of medicine, trainees in psychiatry, and practising psychiatrists.
