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Artificial neural network-based optimized design of reinforced concrete structures
Introduces AI-based Lagrange optimization techniques that can enable more rational engineering decisions for concrete structures while conforming to codes of practice. It shows how objective functions including cost, CO2 emissions, and structural weight of concrete structures are optimized either separately or simultaneously while satisfying constraining design conditions using an ANN-based Lagrange algorithm. Any design target can be adopted as an objective function. Many optimized design examples are verified by both conventional structural calculations and big datasets. Uniquely applies the new powerful tools of AI to concrete structural design and optimization Multi-objective functions of concrete structures optimized either separately or simultaneously Design requirements imposed by codes are automatically satisfied by constraining conditions Heavily illustrated in color with practical design examples
Artificial intelligence in drug design
Looks at applications of artificial intelligence (AI), machine learning (ML), and deep learning (DL) in drug design. The chapters in this book describe how AI/ML/DL approaches can be applied to accelerate and revolutionize traditional drug design approaches such as: structure- and ligand-based, augmented and multi-objective de novo drug design, SAR and big data analysis, prediction of binding/activity, ADMET, pharmacokinetics and drug-target residence time, precision medicine and selection of favorable chemical synthetic routes. How broadly are these approaches applied and where do they maximally impact productivity today and potentially in the near future.
Artificial intelligence for multisource geospatial information
Collects 10 original research contributions published in the Special Issue entitled “Artificial Intelligence for Multisource Geospatial Information” of the ISPRS International Journal of Geo-Information. The focus is on different methods of Geospatial Artificial Intelligence (GeoAI) based on deep learning using different network architectures, clustering, soft computing, and semantic approaches. They are proposed to deal with a variety of Geospatial Big Data (GBD), such as georeferenced texts and photos in social networks, remote sensing images, cartographic maps, multidimensional geo databases, metadata in spatial data infrastructures, and for different tasks, such as for multisource georeferenced text integration and geodata flexible querying, for social sensing by applying sentiment analysis, clustering and geo analysis, for segmentation of roads, clouds and snow, and for detection of small targets and people on the streets.
Applied High-Speed Plate Penetration Dynamics
High-speed impact dynamics is of interest in the fundamental sciences, e.g., astrophysics and space sciences, and has a number of important applications in military technologies, homeland security and engineering.
Applications of nanotechnology in drug discovery and delivery
Presents complete coverage of the application of nanotechnology in the discovery of new drugs and efficient target delivery of drugs. The book highlights recent advances of nanotechnology applications in the biomedical sciences, starting with chapters that provide the basics of nanotechnology, nanoparticles and nanocarriers. Part II deals with the application of nanotechnology in drug discovery, with an emphasis on enhanced delivery of pharmaceutical products, with Part III discussing toxicological and safety issues arising from the use of nanomaterials
Apoptotic pathways as targets for novel therapies in cancer and other diseases
The book attempts to review, summarize, and speculate on the apoptotic pathways, how are they regulated and how targeted therapies are being used to treat a wide variety of diseases. Special emphasis is placed on cancer since new treatments either being developed or currently in the clinical setting are showing great promise to increase survival rates for cancer patients.
Anxiety and Anxiolytic Drugs
The present volume gives a comprehensive overview on the current state of basic and clinical research on Anxiety and Anxiolytic Drugs. Using newly developed methods and techniques researchers are now beginning to understand the molecular mechanisms of anxiety, anxiety disorders and their treatment. In parallel, new drug targets have been generated and the first clinical studies with new compounds have been started. In 20 chapters written by numerous experts in the field comprehensive information on all relevant topics is provided.
Anti-viral metabolites from medicinal plants
Covers general concepts of anti-viral metabolites, classifications, ethnopharmacology, chemistry, clinical and preclinical studies focusing on different medicinal plants against various types of viral infections. Various plants have been used in medicine since ancient times and are known for their strong therapeutic effects. The book will describe potential antiviral properties of medicinal plants against a diverse group of viruses, and provide an insight to the potential plants possess for broad-spectrum antiviral effects against emerging viral infections.The book aims to target a broad audience including virologists, molecular biologist, microbiologist and scientists working with natural products as well as researchers, students, healthcare experts involved in pharmaceutical and medical field.
Antioxidants effects in health : The bright and the dark side ; 1st ed.
Examines the role that antioxidants play in a variety of health and disease situations. The book discusses antioxidants’ historical evolution, their oxidative stress, and contains a detailed approach of 1) endogenous antioxidants, including endogenous sources, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; 2) synthetic antioxidants, including sources, chemistry, bioavailability, legal status, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; and 3) natural antioxidants, including sources, chemistry, bioavailability, mechanisms of action, possible prooxidant activity; beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies. Throughout the boo, the relationship of antioxidants with different beneficial and detrimental effects are examined, and the current controversies and future perspectives are addressed and explored. Antioxidants Effects in Health: The Bright and the Dark Side evaluates the current scientific evidence on antioxidant topics, focusing on endogenous antioxidants, naturally occurring antioxidants and synthetic antioxidants. It will be a helpful resource for pharmaceutical scientists, health professionals, those studying natural chemistry, phytochemistry, pharmacognosy, natural product synthesis, and experts in formulation of herbal and natural pharmaceuticals.
Antibody-drug conjugates and cellular metabolic dynamics
Summarizes the related research achievements in Antibody-drug conjugates (ADCs) and their cell metabolism kinetics. The book has three main parts. The first part describes the basic theory of ADCs, including the basic concept and structure of ADCs, and the relationship between the targets of ADCs and their specific functions. The second part mainly introduces the endocytosis and intracellular metabolism of ADCs, including the relationship between endocytosis and ADC activity, the endocytosis and intracellular transport of ADCs, the distribution and metabolism of ADC in vivo. Then it discusses the new formats and research technology of ADCs, including the application of miniaturized antibodies in ADC synthesis, novel carriers for ADC design, the technology and application of site-specific conjugation, and approaches for analyzing the drug: antibody ratio (DAR), the study of pharmacokinetics of ADCs.
Antibiotics : Methods and protocols
Provides state-of-the-art and novel methods on antibiotic isolation and purification, identification of antimicrobial killing mechanisms, as well as methods for the analysis and detection of microbial responses and adaptation strategies. Antibiotics: Methods and Protocols, Second Edition, guides readers through updated and entirely new chapters on production and design, mode of action, and response and resistance. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Antiangiogenic Agents in Cancer Therapy
Antiangiogenesis remains a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge. Antiangiogenic Agents in Cancer Therapy, Second Edition provides a current, up-dated perspective on the state of the art of angiogenesis and therapy with a compendium of scientific findings and approaches to the study of angiogenesis in cancer. Leaders in the field present chapters on such topics as the environmental influences and the genetic and physiologic abnormalities that mediate angiogenesis and its role in the progression of malignant disease, working models of tumor angiogenesis, and the role of angiogenesis inhibition in the therapy of malignant disease in humans. Comprehensive and cutting-edge, Antiangiogenic Agents in Cancer Therapy, Second Edition is an ideal, valuable guide to the most recent advances in the field, and a collection that will be useful for many years to come.
Analysis file of drug-induced lung injury : expert opinion for analysis of big data
Describes the pathologic conditions of drug-induced lung injuries, monitoring strategies, and guides on how to interpret the evidence. It also dives into particular drugs that caused the disorder, such as EGFR inhibitors, anti-EGFR antibodies, mTOR inhibitors, proteasome inhibitors, immune checkpoint inhibitors, neoangiogenesis inhibitors, and other molecular targeted drugs. It outlines the analysis and interpretation of the post-marketing survey on surveillance of each drug for inducing pulmonary lesions presenting diffuse haziness. The data and analysis from this survey are valuable since a guideline is yet to be established due to limited clinical evidence and cases. As new drugs are developed, establishing treatment and event management is crucial.
Alzheimer's disease : Peptide vaccine and immunotherapy
Peptide vaccines and immunotherapies against aggregating proteins involved in the pathogenesis and progression of Alzheimer's disease (AD) the ẞ-amyloid peptide (Aẞ) and tau are promising therapeutic avenues against AD. Two decades of effort has led to the controversial United States Food and Drug Administration (FDA) approval of the monoclonal antibody Aducamumab (Aduhelm), which has subsequentially sparked the revival and expedited review of promising monoclonal antibody immunotherapies that target Aẞ.
Algebraic Geometry and Geometric Modeling
Algebraic Geometry provides an impressive theory targeting the understanding of geometric objects defined algebraically. Geometric Modeling uses every day, in order to solve practical and difficult problems, digital shapes based on algebraic models. In this book, we have collected articles bridging these two areas. The confrontation of the different points of view results in a better analysis of what the key challenges are and how they can be met. We focus on the following important classes of problems: implicitization, classification, and intersection. The combination of illustrative pictures, explicit computations and review articles will help the reader to handle these subjects.
Aging and Senescence
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and biochemical processes conserved in evolution. Although recent developments in molecular biology are far from understanding the biological basis of aging, research suggests that targeting the aging process itself could ameliorate many age-related pathologies.
Advertising management : Concepts, theories, research and trends
Explores the concept of advertising and the different ways advertising is understood and evaluated. It dives deep into planning, designing, and executing advertising campaigns on different mediums. It discusses the theoretical and research parts of advertising by critically examining how over the years various hierarchical models and theories are developed by advertising experts. It examines various models and theories that explain why and how advertising is successful in persuading customers target audiences to buy a product or accept an idea for behavioural change.
Advances in Unmanned Aerial Vehicles : State of the Art and the Road to Autonomy
There has been tremendous emphasis in unmanned aerial vehicles, both of fixed (airplanes) and rotary wing (vertical take off and landing, helicopters) types over the past ten years. Applications span both civilian and military domains, the latter being the most important at this stage. This edited book provides a solid and diversified reference source related to basic, applied research and development on small and miniature unmanned aerial vehicles, both fixed and rotary wing. As such, the book offers background information on the evolution of such vehicles over the years, followed by modeling and control fundamentals that are of paramount importance due to unmanned aerial vehicle model complexity, nonlinearity, coupling, inhirent instability and parameter values uncertainty. Aspects of navigation, including visual-based navigation and target tracking are discussed, followed by applications to attitude estimation on micro unmanned aerial vehicles, autonomous solar unmanned aerial vehicle, biomimetic sensing for autonomous flights in near-earth environments, localization of air-ground wireless sensor networks, decentralized formation tracking, design of an unmanned aerial vehicle for volcanic gas sampling and design of an on-board processing controller for miniature helicopters.
Advances in Targeted Cancer Therapy
This volume is the first book to cover the general topic of targeted cancer therapy. It presents a range of targets such as tumor angiogenesis, cell cycle control and cell signalling, COX-2, apoptosis/cell survival, invasion and metastasis and approaches like kinase inhibitors, antisense, and antibody-based therapeutics. The emphasis is on preclinical development, including target validation, development of biomarkers, strategies for combination approaches, and development of resistance. The particular challenges involved in translating these data to clinical application are discussed.
Advances in radar systems for target detection and tracking
Radar systems can provide the all-weather and all-time detection and tracking of targets of interest, and they have been extensively applied by the remote sensing community, in applications such as geological exploration, disaster forecasting, traffic monitoring, urban planning, environmental sciences, hydrology, littoral zones, oceans, etc. This reprint contains the several advance research studies on radar systems for target detection and tracking. It includes multipath ghost suppression, maneuvering target tracking, target detection, and other topics.
