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Chemoinformatics : Theory, Practice, & Products
Chemoinformatics: Theory, Practice & Products covers theory, commercially available packages and applications of Chemoinformatics. Chemoinformatics is broadly defined as the use of information technology to assist in the acquisition, analysis and management of data and information relating to chemical compounds and their properties.The book also provides a summary of currently available, state-of-the-art, commercial Chemoinformatics products, with a specific focus on databases, toolkits, and modelling technologies designed for drug discovery.
Chemistry of selected natural products and heterocyclic compounds
Covers the fundamental classification, nomenclature, occurrence, isolation, extraction, occurrence, detection, biosynthesis, medicinal/industrial significance, conversion and inter-conversions, etc.
Chemistry of natural products : phytochemistry and pharmacognosy of medicinal plants
Plants produce secondary metabolites that humans harness for their own benefit. About half of drugs currently in clinical use are based on these chemicals found in nature. Chemistry of Natural Products covers secondary metabolites present in medicinal plants and their biosynthesis, biological activities, and isolation and separation techniques.
Chemistry of Biologically Potent Natural Products and Synthetic Compounds
Several novel natural product derivatives, heterocyclic and other synthetic compounds, have been reported to have shown interesting biological activities including anticancer, antimicrobial, anti-inflammatory, anti-glycemic, anti-allergy and antiviral etc. Provides up-to-date information on new developments and most recent medicinal applications of the natural products and derivatives, as well as the chemistry and synthesis of heterocyclic and other related compounds.
Chemical Genomics ; Vol.58 : Small Molecule Probes to Study Cellular Function
Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry.Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.
Chemical components in some winter vegetables and their effectiveness in treating diseases
Cruciferous (Brassicaceae) vegetables comprise many important species cultivated worldwide and utilized traditionally for culinary and medicinal purposes in different cultures. In the last couple of decades, growing scientific evidence has suggested that consumption of cruciferous vegetables has a preventive role against a variety of human diseases. This prompted the development of nutritional ingredients derived from these vegetables and their use as dietary supplements in different formulations that contain complete plant extracts or specific compounds...
Chemical and functional properties of food components
Described the contents of food raw materials and products, the chemistry/biochemistry of food components, as well as the changes occurring during post-harvest storage and processing affecting the quality of foods. Discusses the role of chemical compounds in the structure of raw materials and the formation of different attributes of food quality, including nutritional value, safety, and sensory properties. It contains four new chapters: “Non-Protein Nitrogenous Compounds”; “Prooxidants and Antioxidants in Food”; “Non-Nutritive Bioactive Compounds in Food of Plant Origin”; and “Analytical Methods Used for Assessing the Quality of Food Products.”
Characterization of Corrosion Products on Steel Surfaces
It is well known that corrosion products, i.e. rust, on iron and steel surfaces cannot be assigned a typical crystallographic structure with long-range order. In fact, the structure of rust is considered to be very complicated, and some forms of rust are assigned to the amorphous state for this reason. Accurate information about the atomic-scale structure of rust is important to shed light on corrosion mechanisms of metallic materials. And, since life of steel structures is often dominated by environmental degradation or corrosion of the surface, the structure of the rust formed on iron and steel surfaces during prolonged exposure to air is of great interest. This book describes the fundamental aspects of materials characterization for the ferric oxyhydroxides formed on steel surfaces.
Characteristic based planning with mySAP SCM™ : Scenarios, processes, and functions
Characteristics are used in SAP as attributes, e.g. to specify the configuration of products or the properties of batches. In many industries – engineering, automotive, mill, pharmaceutical and foods to name the most typical – supply chain planning has to consider these characteristics. APO offers many different functionalities for planning with characteristics, where each of the functionalities has some prerequisites and incompatibilities. This book offers help and advice for the basic design of the implementation by explaining the processes and scenarios (process chains) for planning with characteristics, the functionalities for planning with characteristics in APO including their prerequisites and incompatibilities and the entities, dependencies and system configuration determinants for planning with characteristics in R/3 and APO. This book is based on the releases R/3 4.7 and mySAP SCM 4.1.
Channel strategies and marketing mix in a connected world
Aims to revisit the “traditional” interaction between channel strategies and the marketing mix in a connected world. In particular, it focuses on the following four dimensions in this context: Consumers, Products, Value Proposition and Sustainability. Keeping in mind the growing digitalization of business processes in the retail world and the move towards omni-channel retailing.
Challenge In biologic drug delivery
Biologics are currently one of the most promising avenues for therapeutic interventions in conditions such as metabolic disease, ageing and inflammatory disorders, and for chronic ailments, oral delivery of such medicines has for years been recognised as an important goal. Despite decades of intensive research, oral delivery of biologics is only just starting to prove feasible. There has been much talk about the barriers to uptake of biologics, and indeed, one function of the intestine is to prevent, in one way or another, passage of unwanted materials across the gut, and yet, grams of biological agents both large and small pass across the intestinal cell wall every day. This review first describes the functioning of the gut under normal circumstances, then identifies the principle biological mechanisms, which have been harnessed successfully, to date, to achieve oral uptake, outlining the pros and cons of each approach.
Cell Technology for Cell Products ; Proceedings of the 19th ESACT Meeting, Harrogate, UK, June 5-8, 2005
The 19th ESACT meeting was to highlight the novel capabilities of the industry to move the products towards the clinic and was attended by a wide range of workers in the industry and for many it was their first ESACT meeting. The meeting was started with a session on Transcription to Secretion with a notable set of presentations on the emerging issues. The other sessions that followed Therapeutic Cell Engineering, Gene Medicine, Cells to Tissue, Protein products and Process Technology guided the delegates through the advances made for the progression of the biotechnology towards the industrial application of the products from cells. The meeting was supported by some exceptional invited speakers from around the world whose contributions complemented the emerging technologies and the changes being made at the industrial end of the ESACT spectrum.
Cell Culture Engineering
Many patients suffering with life-threatening diseases or chronic dysfunctions, which were medically untreatable not long ago, can attest to the wonder these drugs have achieved. Although the first generation of p- tein therapeutics was produced in recombinant Escherichia coli, most recent products use mammalian cells as production hosts. Not long after the first p- duction of recombinant proteins in E. coli, it was realized that the complex tasks of most post-translational modifications on proteins could only be efficiently carried out in mammalian cells.
Catalyst separation, recovery and recycling : Chemistry and process design
This book looks at new ways of tackling the problem of separating reaction products from homogeneous catalytic solutions. The new processes involve low leaching supported catalysts, soluble supports such as polymers and dendrimers and unusual solvents such as water, fluorinated organics, ionic liquids and supercritical fluids. The advantages of the different possibilities are discussed alongside suggestions for further research that will be required for commercialisation.
Casting : An Analytical Approach
For a long time, the die cast industry has used trial and error as a leading development method, resulting in tremendous growth in the utilisation of available CFD (computational fluid dynamics) software. This software allows the development of better products that maximise the advantages the die cast process has to offer. Casting: An Analytical Approach will refresh knowledge of the governing laws of the fluid dynamics that have an effect on die cast die and die cast process design. MATLAB® (MathWorks, Inc.) and Visual Basic® (Microsoft) code are listed in Casting: An Analytical Approach for every stage of product, die and die cast process design; providing better understanding of die and process design and simplifying calculations of the die cast die as well as the die cast process. Gas ventilation system calculations and fundamentals of compressible gas flow are also included.
CADD and informatics in drug discovery
Updates knowledge on recent advances in computational and bioinformatics tools/techniques and their practical applications in modern drug design and discovery programme. Also it encompasses fundamental principles, advanced methodologies and applications of various CADD approaches including several cutting-edge areas / presenting recent developments covering ongoing trends in the field of computer-aided drug discovery. Having contributions by a global team of experts, the book is expected to be an ideal resource for drug discovery scientists, medicinal chemists, pharmacologists, toxicologists, phytochemists, biochemists, biologists, RandD personnel, researchers, students, teachers and those working in the field of drug discovery. It will fill the knowledge gaps that exist in the current CADD approaches and methodologies/ protocols being widely used in both academic and research practices. Further, a special focus on current status of various computational drug design approaches (SBDD, LBDD, De-novo drug design, Pharmacophore-based search), bioinformatics tools and databases, computational screening and modeling of phytochemicals/natural products, artificial intelligence and machine learning, and network pharmacology and system biology would certainly guide researchers, students or readers to conduct their research in the emerging area(s) of interest. It is also expected to be highly beneficial to different stakeholders working in the pharmaceutical and biotechnology industries (RandD), the academic as well as research sectors. .
Building information modeling : BIM in current and future practice
"Thought leaders from universities and professional practice composed essays exploring BIM's potential to improve the products and processes of architectural design including the structure and content of the tools themselves. These authors provide insights for assessing the current practice and research directions of BIM and speculate about its future. Design Thinking and BIM / BIM Analytics / Comprehensive BIM / Reasoning with BIM / Professional BIM / BIM Speculations"
Building from waste : Recovered materials in architecture and construction
"Reduce, Reuse, Recycle, and Recover" is the sustainable guideline that has replaced the "Take, Make, Waste" attitude of the industrial age. Based on their background at the ETH Zurich and the Future Cities Laboratory in Singapore, the authors provide both a conceptual and practical look into materials and products which use waste as a renewable resource. It looks into innovative concepts of how materials usually regarded as waste can be processed into new construction elements. The products are organized along the manufacturing processes: densified, reconfigured, transformed, designed and cultivated materials.
Broadband Fixed Wireless Access : A System Perspective
Broadband Fixed Wireless Access provides a systematic overview of the emerging WiMax technology, and much of the material is based on the practical experiences of the authors in building broadband wireless systems. This material will be of significant interest to network architects and developers of broadband fixed wireless access products. With the adoption of the IEEE 802.16 standard and the advent of next generation equipment, the WiMax technology has been growing in interest. The authors discuss applications at microwave frequencies between 2 and 11 GHz that could be attractive options for operators without an existing access infrastructure for reaching end users with broadband services. This introductory volume demystifies the technology and provides technical exposure to the various system trade-offs. Additionally.
Brexit and the Control of Tobacco Illicit Trade
This book assesses the consequences of Brexit for the control of illicit trade in tobacco products in the UK and EU. Based on the currently applicable legal framework, it examines the significance of a possible non-application of the acquis communautaire in the UK in matters relating to anti-illicit trade in tobacco legislation.
