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An introduction to differential geometry with applications to elasticity
Interestingly, notions that pertain to di?erential geometry per se,suchas covariant derivatives of tensor ?elds, are also introduced in Chapters 3 and 4, where they appear most naturally in the derivation of the basic boundary value problems of three-dimensional elasticity and shell theory.
An introduction to bioanalysis of biopharmaceuticals
Provides a comprehensive review of the fundamental and practical aspects of bioanalytical support and the integral role it plays in the development of safe and efficacious biopharmaceutical drugs with speed and cost-effectiveness. Focuses on a broad range of conventional and emerging biopharmaceutical modalities including monoclonal antibody-based therapeutics, gene therapy, cell therapy, peptides and oligonucleotides.
An Atlas of Radioscopic Catheter Placement for the Electrophysiologist
Atlas of Radioscopic Catheter Placement for the Electrophysiologist is unique because it is the first book that provides a teaching tool for fellows in training, allied health professionals and accomplished electrophysiologists on relevant X-ray views commonly encountered in different electrophysiology procedures, and how these views correlate with cardiac anatomy.
An assessment framework for compliance with international space law and norms : Promoting equitable access and Use of space for emerging actors
proposes a framework for assessing countries’ levels of compliance with international space law and norms. It begins by exploring the development of two movements – the evidence-based policymaking and programming movement, and the rise of ratings and rankings research – and their growth across various disciplines. The analysis suggests that such efforts are useful in gauging the behavior of countries in space according to how well they adhere to existing space law and norms. To date, there is no comprehensive, periodic, and systematic measure of countries’ efforts to comply with space law and norms; this work endeavors to fill that gap by offering a framework in which to assess compliance.
Amino acids and the asymmetry of life : Caught in the act of formation
This book describes how the basic building blocks of life, the amino acids, formed. After a comprehensible introduction into stereochemistry, the author addresses the inherent property of amino acids in living organisms, namely the preference for left-handedness. What was the cause for violation of parity of amino acids in the emergence of life on Earth? All the fascinating models proposed by physicists, chemists and biologist are vividly presented including the scientific conflicts.
Amino acid biosynthesis : Pathways, regulation and metabolic engineering
Amino Acids Biosynthesis presents the current knowledge of fundamental as well as applied microbiology of amino acids. Topics discussed are the amino acid biosynthetic pathways, their genetic and biochemical regulation, transport of amino acids and genomics of producing microorganisms. The characterization of the control mechanisms of amino acid biosynthesis has revealed insights into principles of genetic and biochemical regulation, such as transcriptional regulators and a new class of regulatory elements, the riboswitch. The volume further deals with the metabolic engineering of microorganisms for the biotechnological production of amino acids for use as pharmaceuticals and, particularly, as food and feed additives.
Ambient Intelligence in Everyday Life : Foreword by Emile Aarts
Originating from the Workshop on Ambient Intelligence in Everyday Life held at the Miramar Congress Center, San Sebastian, Spain, in July 2005, this book is devoted to the cognitive aspects of ambient intelligence. The 15 carefully reviewed and revised articles presented are organized in topical sections on human-centric computing, ambient interfaces, and architectures for ambient intelligence.
Ambient intelligence for scientific discovery : Foundations, theories, and systems
Many difficult scientific discovery tasks can only be solved in interactive ways, by combining intelligent computing techniques with intuitive and adaptive user interfaces. It is inevitable to use human intelligence in scientific discovery systems: human eyes can capture complex patterns and relationships, along with detecting the exceptional cases in a data set; the human brain can easily manipulate perceptions to make decisions. Ambient intelligence is about this kind of ubiquitous and autonomous human interaction with information. Scientific discovery is a process of creative perception and communication, dealing with questions like: how do we significantly reduce information while maintaining meaning, or how do we extract patterns from massive data and growing data resources. Originating from the SIGCHI Workshop on Ambient Intelligence for Scientific Discovery, this state-of-the-art survey is organized in three parts: new paradigms in scientific discovery, ambient cognition, and ambient intelligence systems. Many chapters share common features such as interaction, vision, language, and biomedicine.
Ambient Intelligence ; European Conference, AmI 2007, Darmstadt, Germany, November 7-10, 2007, Proceedings
This book presented sections on mobility and sensing, applications of AmI, activity and location sensing, AmI and artificial intelligence, AmI middleware and infrastructure, and interaction with the environment. The book is rounded off by a section on case studies and lessons learned, presenting a high level selection of current research reports and papers that reflect the most important activities of current ambient intelligence research.
Ambient intelligence : A novel paradigm
Ambient Intelligence (AmI) is an integrating technology for supporting a pervasive and transparent infrastructure for implementing smart environments. Such technology is used to enable environments for detecting events and behaviors of people and for responding in a contextually relevant fashion. AmI proposes a multi-disciplinary approach for enhancing human machine interaction. The authors start with a description of the iDorm as an example of a smart environment conforming to the AmI paradigm, and introduces computer vision as an important component of the system. Other computer vision examples describe visual monitoring for the elderly, classic and novel surveillance techniques using clusters of cameras installed in indoor and outdoor application domains, and the monitoring of public spaces. Face and speech recognition systems are also covered as well as enhanced LEGO blocks for novel educational purposes. The book closes with a provocative chapter on how a cybernetic system can be designed as the backbone of a human machine interaction.
Alzheimers Disease
Alzheimer’s disease (AD) is a neurodegenerative disease that robs the minds of our elderly population. Approximately one in every eight adults over the age of 65 and nearly half of those over 85 are afflicted with this disease. The aging population in developed societies will impose an ever increasing socioeconomic threat in the future. Current medicines for AD patients are mainly symptomatic treatments and a huge unmet medical need exists to slow the progression of this disease. A great deal of research has been dedicated to understanding the pathogenesis of AD from which comes many ideas for intervening with its progression. Some of these ideas have been fast-tracked to clinical trials due to the availability of medicines with proven clinical efficacies for other diseases (e.g. atorvastatin, simvastatin, rosiglitazone and clioquinol) while others represent novel chemical entities (e.g. glycogen synthase kinase-3 inhibitors).
Alternatives to Animal Testing : Proceedings of Asian Congress 2016
This book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs.
Alternative medicines for diabetes management : Advances in pharmacognosy and medicinal chemistry
Apart from diet and exercise, the strategic use of different classes of prescribed or non-prescribed xenobiotic compounds for the restoration of euglycemic levels in the body is well known. The ongoing rivalry between the recommended usage of allopathic medicines versus ayurvedic remedies has encouraged many researchers to focus their studies on thoroughly isolating and characterizing the extracts from different parts of plants and then evaluating their relative activities via in vitro, in vivo and in some cases clinical studies.
Alqadam Train Station
Aims to focuses on the redesign of the Southern Train Station of Damascus, located in the Al-Qadam area. The proposal aims to preserve the historical identity of the existing station while expanding it to meet the needs of modern urban mobility. The design balances heritage conservation with contemporary architectural expression, creating a space that respects the cultural fabric of Damascus while addressing future growth.Key elements include increasing station capacity, integrating sustainable design strategies, and enhancing passenger flow. Renewable energy use, passive ventilation, and green spaces are central to reducing environmental impact and improving user comfort. يركّز مشروع التخرج هذا على إعادة تصميم المحطة الجنوبية للقطارات في دمشق، الواقعة في منطقة القديهدف المشروع إلى الحفاظ على الهوية التاريخية للمحطة القديمة مع تطويرها وتوسيعها لتلبية احتياجات النقل الحضري المعاصر. يجمع التصميم بين صون التراث والتعبير المعماري الحديث، ليخلق فضاءً يحترم النسيج الثقافي لدمشق ويستجيب في الوقت نفسه لمتطلبات النمو المستقبلي. تشمل العناصر الأساسية زيادة القدرة الاستيعابية للمحطة، ودمج استراتيجيات التصميم المستدام، وتحسين حركة المسافرين. كما يعتمد المشروع على استخدام الطاقة المتجددة، والتهوية الطبيعية، وإضافة المساحات الخضراء لتقليل الأثر البيئي وتعزيز راحة المستخدمين.
Alive : Advancements in Adaptive Architecture
Proposes to embrace the unknown and cultivate the architectural discipline towards an integrated and cross-disciplinary practice. It unravels compelling innovative and forward-thinking design narratives by leading international practitioners and researchers who investigate novel associations between architecture, nature and humanity for a future, alive architecture.
Algorithms in Bioinformatics ; Vol. 3692 ; 5th international workshop, WABI 2005, Mallorca, Spain, October 3-6, 2005, Proceedings
this book present the proceedings of the 5th Workshop on Algorithmsin Bioinformatics (WABI 2005) which took place in Spain, 2005. The Workshop on Algorithms in Bioinformatics highlights research workspecifically developed to address algorithmic problems in biosequence analysis. The emphasis is therefore on statistical and probabilistic algorithms that addressimportant problems in the field of molecular and structural biology. the workshop aims to present recent research results, includingsignificant work in progress, and to identify and explore directions of futureresearch.Original research papers (including significant work in progress) or state-of-the-art surveys were solicited on all aspects of algorithms in bioinformatics,including, but not limited to: exact and approximate algorithms for genomics,genetics, sequence analysis, gene and signal recognition, alignment, molecularevolution, phylogenetics, structure determination or prediction, gene expressionand gene networks, proteomics, functional genomics, and drug design.
Algorithms in Bioinformatics : Theory and Implementation
Explores a comprehensive and insightful treatment of the practical application of bioinformatic algorithms in a variety of fields. Delivers a fulsome treatment of some of the main algorithms used to explain biological functions and relationships. It introduces readers to the art of algorithms in a practical manner which is linked with biological theory and interpretation. The book covers many key areas of bioinformatics, including global and local sequence alignment, forced alignment, detection of motifs, Sequence logos, Markov chains or information entropy. Other novel approaches are also described, such as Self-Sequence alignment, Objective Digital Stains (ODSs) or Spectral Forecast and the Discrete Probability Detector (DPD) algorithm. Readers will also benefit from the inclusion of: A detailed presentation of new methods, such as Self-sequence alignment, Objective Digital Stains and Spectral Forecast ; A treatment of sequence alignment, including local sequence alignment, global sequence alignment and forced sequence alignment with full implementations ; Discussions of position-specific weight matrices, including the count, weight, relative frequencies, and log-likelihoods matrices ; A detailed presentation of the methods related to Markov Chains as well as a description of their implementation in Bioinformatics and adjacent fields ; An examination of information and entropy, including sequence logos and explanations related to their meaning ; A chapter on philosophical transactions that allows the reader a broader view of the prediction process ; Extensive worked examples with detailed case studies that point out the meaning of different results
Algorithms and Models for the Web-Graph ; 5th International Workshop, WAW 2007, San Diego, CA, USA, December 11-12, 2007, Proceedings
The book address a wide variety of topics related to the study of the Web-graph such as random graph models for the Web-graph, PageRank analysis and computation, decentralized search, local partitioning algorithms,and traceroute sampling. The Web-graph has been the focal point of a tremendous amount of research for more than a decade. The view of the Web as a graph has great practical importance and has also generated much interesting theoretical work.
Algorithms and data structures for massive datasets
Learn: Probabilistic sketching data structures for practical problems Choosing the right database engine for your application Evaluating and designing efficient on-disk data structures and algorithms Understanding the algorithmic trade-offs involved in massive-scale systems Deriving basic statistics from streaming data Correctly sampling streaming data Computing percentiles with limited space resources Algorithms and Data Structures for Massive Datasets reveals a toolbox of new methods that are perfect for handling modern big data applications. You'll explore the novel data structures and algorithms that underpin Google, Facebook, and other enterprise applications that work with truly massive amounts of data. These effective techniques can be applied to any discipline, from finance to text analysis. Graphics, illustrations, and hands-on industry examples make complex ideas practical to implement in your projects--and there's no mathematical proofs to puzzle over. Work through this one-of-a-kind guide, and you'll find the sweet spot of saving space without sacrificing your data's accuracy. About the Technology Standard algorithms and data structures may become slow--or fail altogether--when applied to large distributed datasets. Choosing algorithms designed for big data saves time, increases accuracy, and reduces processing cost.
Algorithms and architectures for parallel processing ; 7th International Conference, ICA3PP 2007, Hangzhou, China, June 11-14, 2007, Proceedings
The improvements in computation and communication capabilities have enabled the creation of demanding applications in critical domains such as the environment, health, aerospace, and other areas of science and technology. Similarly, new classes of applications are enabled by the availability of heterogeneous large-scale distributed systems which are becoming available nowadays (based on technologies such as grid and peer-to-peer systems).Parallel computing systems exploit a large diversity of computer architectures, from supercomputers, shared-memory or distributed-memory multi processors, to local networks and clusters of p- sonal computers. With the recent emergence of multi core architectures, parallel computing is now set to achieve “mainstream” status. Approaches that have been advocated by parallel computing researchers in the past are now being utilized in a number of software libraries and hardware systems that are available for everyday use. Parallel computing ideas have also come to dominate areas such as multi user gaming (especially in the development of gaming engines based on “cell” arc- tectures).
