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Antibiotic pharmacokinetic : Pharmacodynamic considerations in the critically Ill
Provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.
Antiangiogenic Agents in Cancer Therapy
Antiangiogenesis remains a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge. Antiangiogenic Agents in Cancer Therapy, Second Edition provides a current, up-dated perspective on the state of the art of angiogenesis and therapy with a compendium of scientific findings and approaches to the study of angiogenesis in cancer. Leaders in the field present chapters on such topics as the environmental influences and the genetic and physiologic abnormalities that mediate angiogenesis and its role in the progression of malignant disease, working models of tumor angiogenesis, and the role of angiogenesis inhibition in the therapy of malignant disease in humans. Comprehensive and cutting-edge, Antiangiogenic Agents in Cancer Therapy, Second Edition is an ideal, valuable guide to the most recent advances in the field, and a collection that will be useful for many years to come.
Anthropological Perspectives on Environmental Communication
Through anthropological and ethnographic analyses, this collection addresses how interests, values, and ideologies affect dialogue and sustainability work. Drawing on studies from three continents – Europe, North America, and South America – the paradoxes and the plurality of meanings associated with the creation of sustainable futures are explored. The book focuses on how communication practices collide with organizational frameworks, customary practices, livelihoods, and landscape.
Anthracycline Chemistry and Biology I : Biological Occurence and Biosynthesis, Synthesis and Chemistry
"This book … covers many different aspects of the origin, chemistry, and biosynthesis of one of the oldest but most important classes of anticancer agents. … In summary, the book is nicely produced, very well edited, and should serve as a valuable source of information … . This book will serve as an inspiration for scientists and students in the areas of chemistry, drug discovery, and biological evaluation. It should be an essential addition to institutional library collections … ."
Antarctica : Contributions to Global Earth Sciences
Sixty articles arranged in eight thematic sections refer to most recent geological and geophysical results of Antarctic research. The Precambrian of the East Antarctic shield and its geological history is considered as well as sub-ice topography, geophysics and stratigraphy, sedimentology and geophysics of the surrounding Southern Ocean. Particular emphasis is given to the connection of the Antarctic and the surrounding continents when forming part of Gondwana.
Antarctic ecosystems : Environmental contamination, climate change, and human impact
This volume provides an overview of climate change data, its effects on the structure and functioning of Antarctic ecosystems, and the occurrence and cycling of persistent contaminants. It discusses the unique physico-chemical characteristics of the Antarctic environment, ecophysiological adaptations of terrestrial and marine organisms, the transfer of contaminants in pelagic and neritic food chains and the possible consequences for animals at higher trophic levels.
Another side of drugs
Drug interactions remain an important consequence of pharmacologic intervention. It is clear that the pharmacologic response of a drug can be markedly influenced by concurrent administration of another therapeutic agent or food. These interactions may result in a decreased therapeutic effect or in an increase in the amount and extent of untoward reactions. Despite the well-described and real clinical consequences of certain drug interactions, this aspect of patient care often continues to be overlooked.
Annotating, Extracting and Reasoning about Time and Events ; International Seminar, Dagstuhl Castle, Germany, April 20-15, 2005, Revised Papers
The book presented centers around an emergingde factost and ardfortime and event annotation: TimeML. TimeML has recently been adopted as a candidate for an ISO standard, and is currently being reviewed in this capacity.It discussions focussed on the following three Time- related issues: using the TimeML language efiectively for consistent annotation, determining how useful such annotation is for further processing,and describing modifications that should be applied to the standard for applications such as question-answering and information retrieval. Discussions at the Dagstuhl Seminar led to new researchideas, and a variety
Animals in space : From research rockets to the space shuttle
Animals in Space will explain why dogs, primates, mice and other rodents were chosen and tested, at a time when dedicated scientists from both space nations were determined to establish the survivability of human subjects on both ballistic and orbital space flights. It will also recount the way this happened; the secrecy involved and the methods employed, and offer an objective analysis of how the role of animals as spaceflight test subjects not only evolved, but subsequently changed over the years in response to a public outcry led by animal activists. It will explore the ways in which animal high-altitude and space flight research impacted on space flight biomedicine and technology, and how the results - both successful and disappointing - allowed human beings to then undertake that same hazardous journey with far greater understanding and confidence.
Animals and the shaping of modern medicine : One health and its histories
This book breaks new ground by situating animals and their diseases at the very heart of modern medicine. In demonstrating their historical significance as subjects and shapers of medicine, it offers important insights into past animal lives, and reveals that what we think of as ‘human’ medicine was in fact deeply zoological.Each chapter analyses an important episode in which animals changed and were changed by medicine. Ranging across the animal inhabitants of Britain’s zoos, sick sheep on Scottish farms, unproductive livestock in developing countries, and the tapeworms of California and Beirut, they illuminate the multi-species dimensions of modern medicine and its rich historical connections with biology, zoology, agriculture and veterinary medicine. The modern movement for One Health – whose history is also analyzed – is therefore revealed as just the latest attempt to improve health by working across species and disciplines.
Anesthesiology : New insights
Provides a comprehensive overview of current developments in anaesthesiology. The chapters : Solutions for Insufficient Epidural Analgesia for Planned Vaginal Birth and Interdisciplinary Emergencies in the Delivery Room, Anesthesia for Robotic Surgeries in Children, Anesthetic Management of Bronchoscopic Lung Volume Reduction, General Anaesthesia in the Context of Haemorrhagic Shock and Trauma, Anesthesiologic Management of Patients with Opioids or Psychoactive Substance Use, Fascial Plane Blocks, Considerations and New Perspectives of Locoregional Anesthesia in Dentistry, The Effect of Parental Anxiety on Postoperative Paediatric Cognitive Dysfunction.
Ancient monuments and modern identities : A critical history of archaeology in 19th and 20th century Greece
Sets out to examine the role of archaeology in the creation of ethnic, national and social identities in 19th and 20th century Greece. The essays included in this volume examine the development of interpretative and methodological principles guiding the recovery, protection and interpretation of material remains and their presentation to the public. The role of archaeology is examined alongside prevailing perceptions of the past, and is thereby situated in its political and ideological context. The book is organized chronologically and follows the changing attitudes to the past during the formation, expansion and consolidation of the Modern Greek State. The aim of this volume is to examine the premises of the archaeological discipline, and to apply reflection and critique to contemporary archaeological theory and practice.
Anatomy for Dental Medicine
Strikes an optimal balance between systemic and regional approaches to complex head and neck anatomy. Award-winning full-color illustrations, succinct text, summary tables, and questions put anatomical structures and knowledge into a practical context. NEW! Additional radiologic images and landmark features throughoutNEW! Reorganized brain/nerve sectionsNEW! Expanded clinical question appendix including patient box questions in the style of the INBDENEW! Factual question appendix places greater emphasis on areas including the skull, larynx, cross sectional anatomy, body below the neck, and local anesthesia
Anatomy : Regional, Surgical, and Applied
Presents a concise, accessible guide to regional and clinically applied anatomy, which clearly demonstrates to students the level of knowledge required for medical and healthcare-related curricula / Uses high-quality clinical and intraoperative images integrated into the text to emphasizes important topics through bullet points / Features logically arranged sections, each devoted to a body region or system, which includes a self-test quiz, with the single best answer and spotter-style questions
Anaphora and Type Logical Grammar
This book develops a hybrid architecture that allows to incorporate anaphora resolution into grammatical deduction while avoiding these consequences. To this end, the grammar logic is enriched with a connective that specifically deals with anaphora.After giving a self-contained introduction into Type Logical Grammar in general, the book discusses the formal properties of this connective. In the sequel, Jäger applies this machinery to numerous linguistic phenomena pertaining to the interaction of pronominal anaphora, VP ellipsis and quantification. In the final chapter, the framework is extended to indefiniteness, specificity and sluicing.
Analyzing the availability of fin tech and its role in enhancing the strategic : Performance of Syrian banks using the balanced scorecard
Aims to examine the role of financial technology (FinTech) in enhancing the strategic performance of Syrian banks by analyzing its impact on the four dimensions of the balanced scorecard : financial performance, customer satisfaction, internal process quality, and learning and growth. Amid economic and technological challenges, integrating fintech emerges as a strategic tool to boost operational efficiency, reduce costs, and promote financial inclusion. The study explores the experiences of several Syrian banks in implementing modern financial technologies, such as digital banking and smart payment systems, while evaluating key financial indicators like return on assets (ROA) and return on equity (ROE).
Analytical Ultracentrifugation VIII
This book presents a comprehensive collection of 21 contributions from leading scientists in this field covering a broad spectrum of topics and presenting recent progress concerning instrumentation, data analysis and modeling, biological systems, particles, colloids, synthetic macromolecules, interacting systems. Due to the versatility of this fascinating and powerful technique, information and original publications are widespread and comprehensive collections are rare. Therefore, this volume presents a valuable source for biologists, chemists, materials scientists, and physicists interested in most recent information, results and development related to this important analytical method.
Analytical Chemistry : Theoretical and Metrological Fundamentals
Fundamentals of Analytical Chemistry are usually presented as a sum of chemical and physical foundations, laws, axioms and equations for analytical methods and procedures. In contrast, this book delivers a practice-oriented, general guiding theory valid for all methods and techniques. Starting with a closer look to analytical signals and their dependencies, all the important figures of merit characterizing the power of analytical procedures and the reliability of analytical results are discussed and quantified, such as sensitivity, precision, accuracy and ruggedness. Elements of signal theory, information theory, statistics and fundamentals of calibration are also presented for this aim.
Analytical approaches for reinforced concrete
Applies deductive reasoning, logic and mathematics to RC. Laying out, deductively, the principles of RC, it encourages researchers to re-imagine and innovate using a solid conceptual framework. Sections consider the reasoning behind key theories, as well as problems that remain unsolved.
Analytical and Stochastic Modeling Techniques and Applications ; 15th International Conference, ASMTA 2008 Nicosia, Cyprus, June 4-6, 2008 Proceedings
This book constitutes the refereed proceedings of the 15th International Conference on Analytical and Stochastic Modeling Techniques and Applications, ASMTA 2008, held in Nicosia, Cyprus, in June 2008.
