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Fundamentals of Renal Pathology
This book will provide the general pathologist, pathology residents and fellows in training, the renal pathologist, and the nephrologist and nephrology resident, with a compact and up-to-date resource on the basics of renal pathology. Beginning with the basic concepts and methods in renal pathology, the text covers renal anatomy, including gross and miscroscopic appearance and pathogenic mechanisms in renal diseases.
Fundamentals of durable reinforced concrete
The book presents a framework for specification through internationally adopted codes and standards and summarises the background to probabilistic approaches to durability design, providing a state-of-the-art review of mathematical modelling of deterioration mechanisms along with current directions in test methods for performance-based specifications.
Frontiers in Anti-Infective Drug Discovery ; Vol.9
Covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field. The ninth volume of this series features 5 reviews that cover some aspects of clinical and pre-clinical antimicrobial drug development, with 2 chapters focusing on drugs to treat leishmaniasis and dengue fever, respectively. - Use of preclinical and early clinical data for accelerating antimicrobial drug development - Post-translational modifications: host defence mechanism, pathogenic weapon, and emerged target of anti-infective drugs - Scope and limitations on the potent antimicrobial activities of hydrazone derivatives - Current scenario of anti-leishmanial drugs and treatment - Dengue hemorrhagic fever: the potential repurposing drugs
From love to medicine : the applications of pheromones in health care
Explores the fascinating world of pheromones, chemical signals that trigger specific behavioral and physiological responses and social interactions in individuals of the same or different species, types, and importance of studying pheromones in a comprehensive manner. Firstly, it delves into the chemical nature of pheromones, including their structures, chemical properties, and the mechanism of action through the Jacobson's organ. Secondly, the project further investigates pheromones' role in communication, examining examples of pheromone-mediated communication and their effects on behavior...
From Innate Immunity to Immunological Memory
The ability to remember an antigenic encounter for several decades, even for a life time, is one of the fundamental properties of the immune system. This phenomenon known as "immunological memory", is the foundation upon which the concept if vaccination rests. Therefore, understanding the mechanisms by which immunological memory is regulated is of paramount importance. Recent advances in immunology, particularly in the field of innate immunity, suggest that the innate immune system plays fundamental roles in influencing immunological memory. Indeed, emerging evidence suggests that events that occur early, within hours if not minutes of pathogen or vaccine entry profoundly shape the quantity, quality and duration of immunological memory. The present volume assembles a collection of essays from leading experts that span the entire spectrum research from understanding the molecular mechanisms of innate immune recognition, to dendritic cell function, to the generation and maintenance of antigen-specific B and T-cell responses.
From GSM to LTE-Advanced Pro and 5G: An Introduction to Mobile Networks and Mobile Broadband
Offers an authoritative guide to the technical descriptions of the various wireless technologies currently in use. Explains the rationale behind their differing mechanisms and implementations while exploring the advantages and limitations of each technology. Reflects the significant changes in mobile network technology that have taken place since the third edition was published. Offers a new chapter on 5G NR that explores its non-standalone and standalone architecture. In the Wi-Fi chapter, additional sections focus on the new WPA3 authentication protocol, the new 802.11ax air interface and protocol extensions like 802.11k and 11v for meshed networks.
From globular proteins to amyloids
Proposes a model and mechanism for explaining protein misfolding. Concepts presented are based on a model originally intended to show how proteins attain their native conformations. This model is quantitative in nature and founded upon arguments derived from information theory. It facilitates prediction and simulation of the amyloid fibrillation process, also identifying the progressive changes that occur in native proteins that lead to the emergence of amyloid aggregations. Introduces basic rules for protein folding, along with the conditions that result in misfolding Presents research that lies in treating the aqueous environment as a continuum rather than a set of individual water molecules (i.e. the classic representation) Provides practical applications for helping the prevention of amyloidosis and improving drug design
Free-Radical-Induced DNA Damage and Its Repair : A Chemical Perspective
Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA. Free-radical DNA damage may lead to mutations, cancer, and cell death. Free radicals have various sources, notably ionizing radiation and oxidative stress. In radiotherapy for cancer and with some anticancer drugs, use is made of cell death by excessive DNA damage. The mechanisms leading to products of free-radical attack which have been studied in models and with small double-stranded DNA fragments are discussed in detail, and the basics of the underlying free-radical chemistry are dealt with in separate chapters.
Fractures du genou = Knee fractures
Provides a comprehensive yet practical overview of the management of knee fractures and their complications. The editorial team comprises specialists from France, Switzerland, Belgium, the United States, and Ireland, many of whom are members of the AO group. Imaging strategies, assessment, classification, and anatomical variations are reviewed for each anatomical location. All therapeutic approaches are discussed without exception: conventional implants, intramedullary nailing, minimally invasive techniques, including the role of external fixation, and newer technologies such as the LISS. These approaches are subjected to critical analysis to identify the best options based on the indications and individual circumstances. The patellar apparatus is addressed in its functional unity. Postoperative management, influenced by functional prognosis, is also covered, as is the management of malunion, stiffness, and other complications. Finally, very specific problems are discussed, such as pediatric injuries, patellectomies, periprosthetic fractures, often complex projectile injuries, the role of immediate arthroplasty and massive grafts, but also associated injuries which sometimes have a heavy impact on the final prognosis.
Foundations of Systematics and Biogeography
the book highlights three principal messages: biological classifications and their explanatory mechanisms are separate notions; most, if not all, homology concepts pre-date the works of Darwin; and that the foundation of all comparative biology is the concept of relationship - neither 'similarity' nor 'genealogical hypotheses of descent' are sufficient. Foundations of Systematics and Biogeography is an ideal volume for students, academics, researchers and professionals in the fields of systematics, biogeography, evolutionary biology and palaeontology.
Foodborne Parasites
Microbiologists are being challenged as foodborne outbreaks are increasingly being observed worldwide. Most of these outbreaks are associated with viral and bacterial pathogens such as Campylobacter, Salmonella, and lately Escherichia coli O157:H7.Foodborne Parasites examines the two major parasite groups that are transmitted via water or foods: the protozoa, which are single celled organisms, and the helminths. The helminths are classified in three sub groups: cestodes (tapeworms), nematodes (round worms), and trematodes (flukes). To better understand their significance, each chapter covers the biology, mechanisms of pathogenesis, epidemiology, treatment, and inactivation of these parasites.
Foodborne Microbial Pathogens : Mechanisms and Pathogenesis
The author presents up-to-date information on molecular and cellular mechanism of several major foodborne microbial pathogens, including select agents for bioterrorism, virulence genes and their regulation in the host or the food environment, pathogenicity testing models, clinical symptoms, and prevention and control strategies. In order to understand the disease process, one must have certain understanding about the role of the immune system. Thus this book also covers the host parasite interaction to a level where the readers will have a better appreciation for the disease mechanism.
Food safety and toxicology : Present and future perspectives
Safety assurance of consumer goods has become a global challenge. The presence of natural and synthetic contaminants in food compromises food safety and poses a risk to public health. Discusses biological and chemical food contaminants, predictive and detection methods of food toxicants, survival mechanism of food pathogens, legislation on microbial contaminants to prevent public health risks and strategies to mitigate contamination.
Food allergens : methods and protocols
Provides a comprehensive collection of methods and protocols in food allergy and food allergens studies. The selected protocols explore the study of food allergens, from recombinant production, purification procedures, IgE and T cell epitopes characterization, to allergen structure description, cellular responses, and tolerance induction, through a variety of techniques and animal models.
Flux Pinning in Superconductors
Covers the flux pinning mechanisms and properties and the electromagnetic phenomena caused by the flux pinning common for metallic, high-Tc and MgB2 superconductors. The condensation energy interaction known for normal precipitates or grain boundaries and the kinetic energy interaction proposed for artificial Nb pins in Nb-Ti, etc., are introduced for the pinning mechanism.
Flavonoids as nutraceuticals
Flavonoids are well-known plant metabolites that have extraordinary properties that can be used for treating health issues. The pharmaceutical importance of flavonoids is due to their anti-depressant, anti-viral, anti-inflammatory, and antioxidant capacities. They are also of great importance when it comes to neuroprotection, cardiovascular disorders, and many types of cancer. Flavonoids are also easily available and produce less harmful side effects than some conventional therapeutics. This new volume examines the growing use of flavonoids for prevention and treatment of diseases and discusses their beneficial mechanisms. Chapters in the volume address diverse uses as anti-aging tools, as anti-inflammatory agents, for treating pregnancy-induced disorders, as a promising tool to combat infection of Covid-19, etc. The book explores their specific therapeutic antiviral potentials, the gene expression by flavonoids, and the role of flavonoids in agriculture.
Fisica solare = Solar physics
An introduction to Solar Physics, intended to illustrate to those who intend to approach this discipline (students, PhDs, researchers) the physical mechanisms underlying the complex phenomena observed on our closest star. It does not claim to be exhaustive (suffice it to say that solar physics spans a wide range of disciplines, such as nuclear physics, thermodynamics, electrodynamics, atomic and molecular physics, spectroscopy across all bands of the electromagnetic spectrum, magnetohydrodynamics, plasma physics, the development of new instrumentation, optics, etc.). Rather, a number of topics of fundamental relevance to the current study of the Sun have been selected (especially with regard to ground-based observations with large telescopes), and an attempt has been made to provide a general overview of these topics, including their historical evolution, without going into excessive detail. Since Solar Physics can rightfully be considered the "Rosetta Stone" of all Astrophysics, the volume can also be considered a valid introduction to this subject.
Fish Histology : Female Reproductive Systems
This volume describes the myriad ways in which fish have approached problems of reproduction — it is an amply illustrated comparative study of the microscopic structure of the female genital systems of fish. The timing of its appearance is auspicious in that it coincides with the decline of the golden age of descriptive morphology. It is a compilation of thousands of micrographs — mostly electron micrographs — from classic works in the field and should prove valuable to investigators studying fish in areas such as ecology, physiology, and reproductive biology who may view histology as essential in their work but have little background in this area. It includes chapters on the origin of genital systems, the structure of ovarian follicles, mechanisms of ovulation, the cortical reaction, oviducts, oviparity, and amazing examples of viviparity.
Fire properties of polymer composite materials
This book is the first to deal comprehensively with the important topic of the fire behaviour of polymer composite materials. Composites are used in a diverse range of applications, including land and marine transport, aerospace, the chemical industry, and most branches of civil engineering infrastructure. It is our belief that fire behaviour is the single most important factor limiting the wider use of composites in many of these areas. Our aim in producing this volume is therefore to stimulate the work that is needed to overcome this fundamental problem. The first step in such a journey is, of course, to summarise what is presently known, which is what we have attempted here. The book covers all of the key issues on the behaviour of polymer composites in fire.
Financial Compensation for Victims of Catastrophes : A Comparative Legal Approach
Some countries have created a specific fund solution; others follow a generous ad hoc approach whereby large amounts of compensation are made available on an ex post basis. This book shall pay attention to all of these seemingly quite different solutions. Experts from different countries report on the way catastrophes are dealt with in their particular jurisdiction from the angle of tort law, social security, insurance or alternative compensation mechanisms such as compensation funds. Various possible remedies for victims are critically discussed; attention is also paid to the economic analysis of law.
