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Drugs Affecting Growth of Tumours
During recent years the field of effective anticancer agents has substantially increased. The use of chemotherapy has been accepted as a standard therapy for an expanding number of tumour types and stages, while many new agents are being investigated when standard therapy is lacking or failing. Apart from new targets for anticancer agents, attention is also focused on improving efficacy and tolerability of existing compounds. This topical volume provides an up-to-date overview of clinically relevant data on anticancer agents, and is not only intended for those working as a medical doctor with cancer patients, but also for medical researchers and students. The different classes of anticancer drugs are described by international authorities on the various topics.
Drug repurposing and computational drug discovery strategies and advances
Defined as identifying new pharmacological indications from old, existing, failed, investigational, already marketed, or FDA-approved drugs and prodrugs, and applying these new uses in the treatment of diseases other than the drug’s original intended therapeutic use. The application of computational techniques in discovery research not only helps in the development of drugs from leads or existing drug molecules but can also be useful for the repurposing of existing drug candidates.
Drift-Driven Design of Buildings : Mete Sozen’s Works on Earthquake Engineering
Summarizes the most essential concepts that every engineer designing a new building or evaluating an existing structure should consider in order to control the damage caused by drift (deformation) induced by earthquakes. It presents the work on earthquake engineering done by Dr. Mete Sozen and dozens of his collaborators and students over decades of experimentation, analysis, and reconnaissance. Many of the concepts produced through this work are integral part of earthquake engineering today. Nevertheless, the connection between the concepts in use today and the original sources is not always explained.
Do Smart Adaptive Systems Exist? : Best Practice for Selection and Combination of Intelligent Methods
This book is intended as a reference and a guide summarising and focusing on best practices when using intelligent techniques and building systems requiring a degree of adaptation and intelligence. Another attractive feature of the book is that it brings together experts from neural network, fuzzy, machine learning, evolutionary and hybrid systems communities who will provide their views on how these different intelligent technologies have contributed and will contribute to creation of smart adaptive systems of the future.
Distribution and phenotype of proliferating cells in the Forebrain of adult macaque monkeys after transient global cerebral ischemia
The authors' results show that ischemia differentially activates endogenous neural precursors residing in diverse locations of the adult primate central nervous system. A limited endogenous potential for postischemic neuronal repair exists in neocortex and striatum, but not in the hippocampus proper of the adult macaque monkey brain. The presence of putative parenchymal progenitors and of sustained progenitors in germinative centers opens novel possibilities for precursor cell recruitment.
Discrete-Time Markov Chains : Two-Time-Scale Methods and Applications
The motivation stems from existing and emerging applications in optimization and control of complex hybrid Markovian systems in manufacturing, wireless communication, and financial engineering. Much effort in this book is devoted to designing system models arising from these applications, analyzing them via analytic and probabilistic techniques, and developing feasible computational algorithms so as to reduce the inherent complexity. This book presents results including asymptotic expansions of probability vectors, structural properties of occupation measures, exponential bounds, aggregation and decomposition and associated limit processes, and interface of discrete-time and continuous-time systems. One of the salient features is that it contains a diverse range of applications on filtering, estimation, control, optimization, and Markov decision processes, and financial engineering.
Discovering Knowledge in Data : An Introduction to Data Mining
Provides the tools needed to thrive in today’s big data world. Demonstrates how to leverage a company’s existing databases to increase profits and market share, and carefully explains the most current data science methods and techniques. The reader will “learn data mining by doing data mining”.
Direct and indirect resin composite veneers
Re-establishing a patient’s lost dental asthetic appearance is one of the most important topics for contemporary dentistry.New treatment materials and methods have been coming on the scene, day by day, in order to achieve such an aim. Most dentists prefer more conservative and aesthetic approaches. Laminate veneers are restorations which are envisioned to correct existing abnormalities, esthetic deficiencies and discolorations. Laminate veneer restorations may be processed in two different ways: direct or indirect. Direct resin composite veneers are one of the most commonly used restorations in the treatment of poor esthetics in anterior teeth presenting unsatisfactory colour and shape, defective restorations, slight misalignment and fractures.
Dimension Reduction of Large-Scale Systems ; Proceedings of a Workshop held in Oberwolfach, Germany, October 19-25, 2003
In the past decades, model reduction has become an ubiquitous tool in analysis and simulation of dynamical systems, control design, circuit simulation, structural dynamics, CFD, and many other disciplines dealing with complex physical models. The aim of this book is to survey some of the most successful model reduction methods in tutorial style articles and to present benchmark problems from several application areas for testing and comparing existing and new algorithms. As the discussed methods have often been developed in parallel in disconnected application areas.
Digital twin technology : fundamentals and applications
Provides an in-depth examination of digital twin technology to take you on an enthralling trip across the intersection of the virtual and real worlds. It explores the transformational impact of digital twins, from their roots in engineering to their widespread applications in manufacturing, health care, and other areas. Real-world case studies highlight the practical benefits, while potential hazards are addressed wisely. This book is your guide to comprehending the present and visualizing a future where digital twins transform innovation, efficiency, and connectedness in our increasingly complicated world. Begin this illuminating trip and embrace the possibilities that exist at the intersection of the physical and digital worlds.
Digital Simulation in Electrochemistry
The book shows how to numerically solve the parabolic partial differential equations (pdes) encountered in electroanalytical chemistry. It does this in a didactic manner, by first introducing the basic equations to be solved and some model systems as text cases, for which solutions exist. Then it treats basic numerical approximation for derivatives and techniques for the numerical solution of ordinary differential equations, from which the more complicated methods for pdes can be derived. The major implicit methods are described in detail, and the handling of homogeneous chemical reactions, including coupled and nonlinear cases, is detailed. More advanced techniques are presented briefly, as well as some commercially available program packages.
Device Applications of Nonlinear Dynamics
This edited book is devoted specifically to the applications of complex nonlinear dynamic phenomena to real systems and device applications. While in the past decades there has been significant progress in the theory of nonlinear phenomena under an assortment of system boundary conditions and preparations, there exist comparatively few devices that actually take this rich behavior into account. "Device Applications of Nonlinear Dynamics" applies and exploits this knowledge to make devices which operate more efficiently and cheaply, while affording the promise of much better performance. Given the current explosion of ideas in areas as diverse as molecular motors, nonlinear filtering theory, noise-enhanced propagation, stochastic resonance and networked systems, the time is right to integrate the progress of complex systems research into real devices.
Development Policies and Policy Processes in Africa : Modeling and Evaluation
Examines the methodological challenges in analyzing the effectiveness of development policies. It presents a selection of tools and methodologies that can help tackle the complexities of which policies work best and why, and how they can be implemented effectively given the political and economic framework conditions of a country. The contributions in this book offer a continuation of the ongoing evidence-based debate on the role of agriculture and participatory policy processes in reducing poverty. They develop and apply quantitative political economy approaches by integrating quantitative models of political decision-making into existing economic modeling tools, allowing a more comprehensive growth-poverty analysis.
Detection and analysis of SARS Coronavirus : Advanced biosensors for pandemic viruses and related pathogens
The highly contagious SARS CoV-2 pathogen has challenged health systems around the world as they struggle to detect and monitor the spread of the pathogen. In Detection and Analysis of SARS Coronavirus: Advanced Biosensors for Pandemic Viruses and Related Pathogens expert chemists Chaudhery Mustansar Hussain and Sudheesh K. Shukla deliver a practical analysis of how contactless coronavirus detectors may be developed using existing biosensor technology.
Designing Urban Food Policies : Concepts and Approaches
This book is for scientists and experts who work on urban food policies. It provides a conceptual framework for understanding the urban food system sustainability and how it can be tackled by local governments. Written by a collective of researchers, this book describes the existing conceptual frameworks for an analysis of urban food policies, at the crossroads of the concepts of food system and sustainable city.
Design Thinking for Visual Communication
Identifies methods and thought processes used by designers in order to start the process that eventually leads to a finished piece of work. Step-by-step guidance for each part of the process is highlighted by real-life case studies, enabling the student to see teaching in practice. This focus on ideas and methods eschews an abstract, academic approach in favour of a useable approach to design as a problem-solving activity. The new edition now includes contributions from a broader international range of design practices and adds depth to existing case studies by looking in greater detail at some of the processes used
Design of adaptive finite Element software : The finite element toolbox ALBERTA
During the last years, scientific computing has become an important research branch located between applied mathematics and applied sciences and engineering. Highly efficient numerical methods are based on adaptive methods, higher order discretizations, fast linear and non-linear iterative solvers, multi-level algorithms, etc. Such methods are integrated in the adaptive finite element software ALBERTA. It is a toolbox for the fast and flexible implementation of efficient software for real life applications, based on modern algorithms. ALBERTA also serves as an environment for improving existent, or developing new numerical methods in an interplay with mathematical analysis and it allows the direct integration of such new or improved methods in existing simulation software.
Design and analysis of randomized algorithms : Introduction to design paradigms
Randomness is a powerful phenomenon that can be harnessed to solve various problems in all areas of computer science. Randomized algorithms are often more efficient, simpler and, surprisingly, also more reliable than their deterministic counterparts. Computing tasks exist that require billions of years of computer work when solved using the fastest known deterministic algorithms, but they can be solved using randomized algorithms in a few minutes with negligible error probabilities. Introducing the fascinating world of randomness, this book systematically teaches the main algorithm design paradigms – foiling an adversary, abundance of witnesses, fingerprinting, amplification, and random sampling, etc. – while also providing a deep insight into the nature of success in randomization. Taking sufficient time to present motivations and to develop the reader's intuition, while being rigorous throughout, this text is a very effective and efficient introduction to this exciting field.
Dental biomaterials: from fundamental principles to clinical applications
Novel approaches are being developed to prevent and treat prevalent oral diseases like dental caries, periodontitis, and oral cancer. Researchers are also exploring the potential of biomaterials in regenerative dentistry, such as promoting bone growth and repairing damaged oral tissues.The ongoing research and development in dental materials and biomaterials holds great promise for improving oral health outcomes. However, it is imperative to maintain a sustained focus on research to fully leverage their potential and effectively address the existing gaps in dental care.In the special issue titled "Dental Biomaterials: From Fundamental Principles to Clinical Applications," significant findings have emerged from a variety of sources, including in vitro experiments and clinical trials.
Defects in High-k Gate Dielectric Stacks : Nano-Electronic Semiconductor Devices
One of the key obstacles to high-k integration into Si nano-technology are the electronic defects in high-k materials. It has been established that defects do exist in high-k dielectrics and they play an important role in device operation. However, very little is known about the nature of the defects or about possible techniques to eliminate, or at least minimize them. Given the absence of a feasible alternative in the near future, well-focused scientific research and aggressive development programs on high-k gate dielectrics and related devices must continue for semiconductor electronics to remain a competitive income producing force in the global market.
