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Natural anti-depressant drugs
Mental health problem and neurological disorders are a serious public health concern globally with more than one billion sufferers worldwide. Depression, anxiety, stress, and other mental disorders, which are on the rise worldwide, are indications that pharmacological therapy can have serious adverse effects, which is why many patients prefer to use herbal products to treat these symptoms. Because pharmacotherapy of depression is a long-term process associated with the risk of numerous adverse drug effects, much attention is paid to alternative therapy methods, including phytopharmacotherapy, especially in treating mild or moderate depression.
Myosins : A Superfamily of Molecular Motors
Application of state-of-the-art cellular and molecular biological, structural biological, genetic, biochemical and biophysical techniques has provided and continues to provide critical information regarding the structure–function relationship; and the cellular roles of various myosins in organisms as diverse as protozoa, yeast, plants and higher animals. The association of myosins with diseases including neurological disorders, immu- deficiencies, cardiomyopathies, hearing and vision loss testify to the importance of understanding the biochemical properties and cellular roles of myosins. The 16 chapters in this volume summarize the tremendous progress made in studying members of the myosin superfamily in recent years and offer critical insight into what future research will yield.
Myeloproliferative disorders
Contains a series of contributions from internationally renowned academics with special expertise in one or other diseases which collectively are grouped under the heading myeloproliferative disorders. This term includes Ph-positive chronic myeloid leukemia as well as the various Ph-negative variants.
Musculoskeletal disorders : The fatigue failure mechanism
Experts delivers an essential and incisive discussion of how musculoskeletal disorders (MSDs) develop and progress, as well as how they can be prevented and controlled. Offering a novel, evidence-based approach to this costly problem, the book has broad implications for employers, insurers, and other stakeholders in workplace health and safety.
Multiple Sclerosis: Autoimmunity and Management
Multiple sclerosis (MS) is an immune-mediated inflammatory disease that attacks myelinated axons in the central nervous system, destroying the myelin and the axon in variable degrees and producing significant physical disability within 20–25 years in more than 30% of patients. The hallmark of MS is symptomatic episodes that occur months or years apart and affect different anatomic locations. Also, see the Autoimmune Disorders: Making Sense of Nonspecific Symptoms slideshow to help identify several diseases that can cause a variety of nonspecific symptoms. MS is diagnosed on the basis of clinical findings and supporting evidence from ancillary tests. Treatment consists of immunomodulatory therapy for the underlying immune disorder and management of symptoms, as well as nonpharmacologic treatments, such as physical and occupational therapy. Disease-modifying therapies have shown beneficial effects in patients with relapsing MS, including reduced frequency and severity of clinical attacks. These agents appear to slow the progression of disability and the reduce accumulation of lesions within the brain and spinal cord.
MRI of the Temporomandibular Joint : Correlation Between Imaging and Pathology
This book is the outcome of a fruitful, long-standing cooperation between expert radiologists and clinicians, and explains the most relevant features and technical requirements that are needed to optimally conduct and assess MR examinations for temporomandibular joint (TMJ) pathologies.
MRI and CT of the Female Pelvis
MRI and CT exquisitely depict the anatomy of the female pelvis and offer fascinating diagnostic possibilities in women with pelvic disorders. This volume provides a comprehensive account of the use of these cross-sectional imaging techniques to identify and characterize developmental anomalies and acquired diseases of the female genital tract. Both benign and malignant diseases are considered in depth, and detailed attention is also paid to normal anatomical findings and variants. Further individual chapters focus on the patient with pelvic pain and the use of MRI for pelvimetry during pregnancy and the evaluation of fertility. Throughout, emphasis is placed on the most recent diagnostic and technical advances, and the text is complemented by many detailed and informative illustrations.
MR Imaging in White Matter Diseases of the Brain and Spinal Cord
Comprises a series of comprehensive and up-to-date reviews on the use of MR imaging in these major neurological conditions. The diverse available MR techniques, such as magnetization transfer MRI, diffusion-weighted MRI, MR spectroscopy, functional MRI, cell-specific MRI, perfusion MRI, and microscopic imaging with ultra-high field MRI, offer an extraordinarily powerful means of gaining fundamental in vivo insights into disease processes. The strengths and weaknesses of all these techniques in the study of multiple sclerosis and other relevant diseases are extensively considered. After an introductory section on neuroimaging technology, subsequent sections address disorders of myelination, demyelinating diseases, immune-mediated disorders, and white matter disorders related to aging and other conditions. This book provides a valuable summary of the state of the art in the field, and defines important areas for future research.
Motor Control and Learning
Motor Control and Learning focuses on the effects of development, aging, and practice on the control of human voluntary movement. These issues have been at the center of attention of the motor control community, but no book until now has addressed all of these issues under one cover in the context of contemporary views on the control of human voluntary movement. This book emphasizes the links between progress in basic motor control research and applied areas such as motor disorders and motor rehabilitation.
Molecular Mechanisms of Synaptogenesis
Molecular Mechanisms of Synaptogenesis is a compilation of recent exciting findings that summarizes the ever-expanding knowledge of how neuronal contacts develop in the normal brain and how their functions are affected in mental disorders. In the last decade, advances in molecular and cellular biology, combined with the development of sophisticated fluorescence microscopy tools to visualize synapses in live neurons, have revealed many intriguing and unexpected findings regarding the dynamics of synapse formation. Studies by a number of researchers have identified several critical protein components of synapses and shown the time course of their arrival at the synapse. Several molecules serve to hold the synaptic contacts between nerve cells and regulate their function.
Molecular Markers of Brain Tumor Cells : Implications for Diagnosis, Prognosis and Anti-Neoplastic Biological Therapy
Childhood brain tumors are a diverse group of diseases characterized by the abnormal growth of tissue contained within the skull. Other than leukemia and lymphoma, brain tumors are the most common type of neoplasms that occur in children. The leading cause of death from childhood neoplasms among persons up to 19 years is brain tumors. As such, this book is a review of the most recent molecular biological research concerning brain tumors with references and comparisons to a variety of neoplastic disorders. The book then uses this information to foreshadow the direction that future anti-neoplastic therapies will take. Because of the wide spectrum of the objectives of the book, any individual involved in cancer research will greatly benefit from the work. Histopathologists, neuropathologists, clinical and research oncologists, and medical students will find this book to be an invaluable resource as a reference guide. Patients and their families will also find the book useful as it offers a comprehensive update on new, non-classical therapeutic modality options and contains a detailed description and analysis of brain tumors. Such an endeavor has yet to be undertaken by any other book and may prove to be the most comprehensive book on brain tumors thus far.
Molecular autoimmunity
The autoimmune disease paroxysmal cold hemoglobinuria, a rare hemolytic disorder. After a century of research, the list of autoimmune diseases has become impressive. With a prevalence of approximately 5% of the world-wide population, these chronic, debilitating conditions affect almost every major organ of the body and, for reasons that remain unclear, are much more prevalent in woman than in men. Despite our rapidly expanding knowledge of the cellular and molecular pathways that govern a normal immune response, deciphering the precise etiology of autoimmune diseases remains an important challenge. Over the last few years, our understanding of the pathogenesis of autoimmune diseases has improved rapidly, leading to the emergence of elegant immunointervention strategies. Molecular Autoimmunity illustrates how cutting-edge research is continuing to advance our understanding of autoimmune disease mechanisms and identifies novel therapeutic targets that provide a hope for effective future treatments. This volume contains a selected number of exciting advances in unraveling autoimmune reactions, and the resulting new armory of experimental immunotherapies that may lead to new ways of controlling autoimmune reactions.
Molecular and Cellular Signaling
A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kinds of cells are made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Molecular and Cellular Signaling provides an introduction to molecular and cellular signaling in biological systems with an emphasis on the underlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadening their understanding of how cells regulate and coordinate their core activities and how diseases arise when these regulatory systems malfunction, as well as those in chemistry, physics and computer science interested in pursuing careers in biological and medical physics, bioinformatics and systems biology. To that end, the book includes background information and review sections, and chapters on signaling in the immune, endocrine (hormonal) and nervous systems. It has chapters on cancer, apoptosis and gene regulation, and contains chapters on bacteria and viruses. In those chapters not specifically devoted to pathogens, connections between diseases, drugs and signaling are made. Each chapter also features a problem set to facilitate further discussion and understanding.
Modern treatments for chronic blood diseases
Blood is a body fluid in humans and other animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells. In vertebrates, it is composed of blood cells suspended in blood plasma. Plasma, which constitutes 55% of blood fluid, is mostly water (92% by volume), and contains proteins, glucose, mineral ions, hormones, carbon dioxide (plasma being the main medium for excretory product transportation), and blood cells themselves. Albumin is the main protein in plasma, and it functions to regulate the colloida osmotic pressure of blood. The blood cells are mainly red blood cells (also called RBCs or erythrocytes), white blood cells (also called WBCs or leukocytes) and platelets (also called thrombocytes). Thalassemias are inherited blood disorders characterized by decreased hemoglobin production Symptoms depend on the type and can vary from none to severe. Often there is mild to severe anemia (low red blood cells or hemoglobin). Anemia can result in feeling tired and pale skin. There may also be bone problems, an enlarged spleen, yellowish skin, and dark urine. Slow growth may occur in children.
Modafinil as a drug to raise mental and cognitive abilities
Investigates the scientific foundation of Modafinil’s cognitive effects, examining its pharmacodynamics, pharmacokinetics, and clinical applications. Furthermore, it explores the drug’s comparative advantages over natural cognitive enhancers, its side effect profile, patterns of use, and broader societal impact. By offering a comprehensive overview, this study aims to contribute to a better understanding of Modafinil as a modern cognitive enhancer in both medical and non-medical contexts.
Migraine
Migraine is a chronic paroxysmal neurological disorder characterised by multiphase attacks of head pain and a myriad of neurological symptoms. The underlying genetic and biological underpinnings and neural networks involved are coming sharply into focus. This progress in the fundamental understanding of migraine has led to novel, mechanism-based and disease-specific therapeutics. In this Seminar, the clinical features and neurobiology of migraine are reviewed, evidence to support available treatment options is provided, and emerging drug, device, and biological therapies are discussed.
Migraine
Migraine is one of the most common diseases of the present era, it ranked sixth in the world for neurological diseases, it’s severity varies from person to person and may interfere with daily activities in our article ,we will discuss the mechanisms of migraine occurrence, it’s traditional treatments and the modern treatment used internationally it is also possible that the migraine is a symptom or a predictor of serious diseases which we will learn about in this research.
Micro-, Meso- and Macro-Connectomics of the Brain
Highlights cutting-edge methods that can accelerate progress in elucidating static ‘hard-wired’ circuits of the brain as well as dynamic interactions that are vital for brain function. The power of connectomic approaches in characterizing abnormal circuits in the many brain disorders that afflict humankind is considered. Experts in computational neuroscience and network theory provide perspectives needed for synthesizing across different scales in space and time. Altogether, this book provides an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.
Metabolism and Functions of Bioactive Ether Lipids in the Brain
This book will be particularly useful to neuroscience graduate students, academics, and researchers. Clinicians will find this book useful for understanding molecular aspects of neurodegeneration in acute neural trauma and neurodegenerative diseases that are mediated by plamalogen-selective phospholipases A2 and PAF acetyl hydrolases. This monograph is the first to provide a comprehensive description of not only metabolism and role of plasmalogen and platelet activating factor in brain tissue but also the involvement of these lipids with abnormal signal transduction processes in neurological disorders.
Mental health disorders in pregnancy and the early postpartum
Mental health disorders are common in pregnancy and after childbirth with over 10% of women manifesting some form of mental illness during this time. Maternity services will encounter women with symptoms that vary in severity from mild self-limiting to potentially life-threatening. These conditions carry risks for both the woman and the fetus/newborn. Detecting women with, or at risk of, a serious mental health disorder and enabling them to access appropriate care in a timely fashion is a shared responsibility. However, given the frequency of contact they have with women through this period, maternity services have a pivotal role. From a mental health perspective, high-risk pregnancies are those primarily associated with serious mental illness (psychotic illnesses, bipolar disorder and severe depressive episodes). Healthcare professionals caring for pregnant women should have the appropriate skills to detect serious mental illness and identify women at risk and how to access specialist mental health care.
