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Deoxynucleoside Analogs in Cancer Therapy
Emerging as an important new volume in the renowned Cancer Drug Discovery and Development™ series, Deoxynucleoside Analogs in Cancer Therapy expertly summarizes the current status of development and application of deoxynucleoside analogs. Authoritative up-to-date reviews are presented by scientists well known in their specific areas and all contributions include valuable sound advice on structure and topics. Organized into several sections, the first part covers general aspects of drug uptake and metabolism and explains how novel technology has enabled a rapid expansion of this field. The second part is concerned with a number of specific drugs including cytarabine, gemcitabine, troxacitabine, clofarabine and Ara-G. The final section covers pharmacokinetics, prodrugs, and specific applications such as radiosensitization, gene therapy, and the use of deoxynucleoside analogs as tracers
Dental materials : Properties and manipulation ; 11th ed.
Comprehensive and cutting-edge content describes the latest materials commonly used in dental practice, including those in esthetics, ceramics, dental implants, and impressions. Approximately 500 illustrations and photographs make it easier to understand properties and differences in both materials and specific types of products. Review questions provide an excellent study tool with 20 to 30 self-test questions in each chapter. Quick Review boxes summarize the material in each chapter. Note boxes highlight key points and important terminology throughout the text. Key terms are bolded at their initial mention in the text and defined in the glossary. A logical and consistent format sets up a solid foundation before progressing into discussions of specific materials, moving from the more common and simple applications such as composites to more specialized areas such as polymers and dental implants. Learning objectives in each chapter focus readers’ attention on essential information. Supplemental readings in each chapter cite texts and journal articles for further research and study.
Deliberative public engagement with science : An empirical investigation
This compact open access reference delves beyond popular concepts of educated consumers and an informed public by examining the science behind deliberative engagement. Using data from four longitudinal studies, the authors assess public engagement methods in deliberative discussions of ethical, legal, and social issues concerning innovations in nanotechnology. Coverage includes the theoretical origins of the studies, forms of engagement and variations used, and in-depth details on cognitive, affective, and social components that go into the critical thinking process and forming of opinions. Not only are the findings intriguing in and of themselves, but researchers from varied fields will also find them useful in pursuing their own projects.
Deep Statistical Comparison for Meta-heuristic Stochastic Optimization Algorithms
Presents a comprehensive comparison of the performance of stochastic optimization algorithms / Includes an introduction to benchmarking and statistical analysis / Provides a web-based tool for making statistical comparisons of optimization algorithms / Overviews of the current approaches used to analyze algorithm performance in a range of common scenarios, while also addressing issues that are often overlooked. In turn, it shows how these issues can be easily avoided by applying the principles that have produced Deep Statistical Comparison and its variants. The focus is on statistical analyses performed using single-objective and multi-objective optimization data. At the end of the book, examples from a recently developed web-service-based e-learning tool (DSCTool) are presented. The tool provides users with all the functionalities needed to make robust statistical comparison analyses in various statistical scenarios. The book is intended for newcomers to the field and experienced researchers alike. For newcomers, it covers the basics of optimization and statistical analysis, familiarizing them with the subject matter before introducing the Deep Statistical Comparison approach. Experienced researchers can quickly move on to the content on new statistical approaches.
Deep learning for computational problems in hardware security : Modeling attacks on strong physically unclonable function circuits
Discusses a broad overview of traditional machine learning methods and state-of-the-art deep learning practices for hardware security applications, in particular the techniques of launching potent "modeling attacks" on Physically Unclonable Function (PUF) circuits, which are promising hardware security primitives. The volume is self-contained and includes a comprehensive background on PUF circuits, and the necessary mathematical foundation of traditional and advanced machine learning techniques such as support vector machines, logistic regression, neural networks, and deep learning. This book can be used as a self-learning resource for researchers and practitioners of hardware security, and will also be suitable for graduate-level courses on hardware security and application of machine learning in hardware security.
Deep learning approach for text summarization
Machine learning and deep learning, as we know, have started ruling over almost every field in the computing industry and so, has revolutionized the process of text summarization too. Automatic text summarization is an advancing realm of the natural language processing research in which concise textual summaries are generated from lengthy input documents. Extensive research has been carried out on how automatic summarization can be prosecuted through various extractive and abstractive techniques. In this paper, we address all the approaches to text summarization and present the modus operandi of an Architecture called Encoder Decoder, under the machine learning approach.
Data Warehousing and Data Mining Techniques for Cyber Security
It provide techniques for collecting information from distributed databases and for performing data analysis. The ever expanding, tremendous amount of data collected and stored in large databases has far exceeded our human ability to comprehend--without the proper tools. There is a critical need for data analysis that can automatically analyze data, summarize it and predict future trends. In the modern age of Internet connectivity, concerns about denial of service attacks, computer viruses and worms are extremely important. Data Warehousing and Data Mining Techniques for Cyber Security contributes to the discipline of security informatics. The author discusses topics that intersect cyber security and data mining, while providing techniques for improving cyber security. Since the cost of information processing and internet accessibility is dropping, an increasing number of organizations are becoming vulnerable to cyber attacks. This volume introduces techniques for applications in the area of retail, finance, and bioinformatics, to name a few.
Data Streams : Models and Algorithms
It primarily discusses issues related to the mining aspects of data streams rather than the database management aspect of streams. This volume covers mining aspects of data streams in a comprehensive style. Each contributed chapter, from a variety of well known researchers in the data mining field, contains a survey on the topic, the key ideas in the field from that particular topic, and future research directions.
Data center networking : Network topologies and traffic management in large-scale data centers
Provides a comprehensive reference in large data center networking. It first summarizes the developing trend of DCNs, and reports four novel DCNs, including a switch-centric DCN, a modular DCN, a wireless DCN, and a hybrid DCN. Furthermore another important factor in DCN targets at managing and optimizing the network activity at the level of transfers to aggregate correlated data flows and thus directly to lower down the network traffic resulting from such data transfers. In particular, the book reports the in-network aggregation of incast transfer, shuffle transfer, uncertain incast transfer, and the cooperative scheduling of uncertain multicast transfer.
Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases
Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases.This book summarizes the findings of the 56th International Workshop of the Ernst Schering Research Foundation that focused on "Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases".
Cytogenetics and molecular cytogenetics
Genomic technologies provide the means of diagnosis and management of many human diseases. Without insights from cytogenetics, correct interpretation of modern high-throughput results is difficult, if not impossible. This book summarizes applications of cytogenetics and molecular cytogenetics for students, clinicians and researchers in genetics, genomics and diagnostics. The book combines the state-of-the-art knowledge and practical expertise from leading researchers and clinicians and provides a comprehensive overview of current medical and research applications of many of these technologies.
Cytochrome P450 : Structure, Mechanism, and Biochemistry
In this newest edition, we find that the newest discussion of P450 structure includes information of bacterial (soluble) P450s interwoven with that of eukaryotic (membrane bound) of this superfamily, highlighting the newest developments in this area. The complete battery of human P450s is now known and summarized in the new edition. In addition, general overviews of plant P450s and those from microbes contained within this newest edition provide a broader view of P450 diversity than seen in earlier editions. Each of these three editions should be on bookshelves of laboratories studying P450s. The third edition of Cytochrome P450: Structure, Mechanism, and Biochemistry provides an opportunity to judge progress in many key areas of P450 research while at the same time learn of new directions in the field. It is an excellent and most useful volume.
Cyclized Helical Peptides : Synthesis, Properties and Therapeutic Applications
Constraint helical peptides have emerged as a solution to target previously undruggable protein-protein interactions, which feature large and complex surfaces. Cyclized Helical Peptides: Synthesis, Properties and Therapeutic Applications offers a review of the most current methodologies of constructing constrained helices. The authors noted experts on the topic include the information on the fundamental features of cyclized helical peptides and discuss their limitations. The book summarizes and explores the effects of chemical methods constructing helical peptides on helicity, binding affinity, cell penetration, and nonspecific toxicity
Ctenophores : Methods and protocols
Explores emerging approaches and methods inspired by recent research using ctenophores or placozoans, facilitating the study of these enigmatic species and ancient animal lineages. Practical protocols are integrated with introductory chapters about general biology, summarizing the diversity, evolution, genomics, development, and neurobiology of these organisms. Special chapters outline strategies and applications for culturing, microscopy, physiology, electrical synapses, and bioluminescence, molecular and single-cell biology, transcription factors, as well as gene and protein expression analyses. The book also contains bioinformatics and computational chapters covering peptidomics and epigenomics. Written for the highly successful Methods in Molecular Biology series, chapters include detailed implementation advice that leads to dependable results in the laboratory.
Critical Points for the Organisation of Test Performance Studies in Microbiology : Plant Pathogens as a Case Study
This book in the field of plant pest detection shows a constant demand in development and improvement of fast and reliable detection tools, especially for high-priority pests. This open access book describes and summarizes the whole process of the organization of test performance study (TPS) for these tools. The outcome of TPS, obtained through the evaluation of the performance of one or more diagnostic tests by several laboratories on defined samples, is the finding of the best performing test/s for particular pest and for specific uses.
COVID-19 in Alzheimer's disease and dementia
COVID-19 in Alzheimer’s Disease and Dementia crucially summarizes the current status of the coronavirus in patients suffering from these conditions, describing why they are a common cause of morbidity among those with COVID-19. The first section includes chapters that provide a general description of COVID-19, including SARS-CoV-2 structure, function, and biology, and its impact on the elderly with chronic conditions include hypertension, diabetes, obesity, kidney disease, respiratory illnesses, and infectious diseases. Also discussed are effects of the virus on the immune system. The second section shifts to the impact of COVID-19 on those with dementia or Alzheimer’s disease, with special emphasis on age, gender, ethnic background, and lifestyle.
Cortical Deficits In Schizophrenia : From Genes to Function
Opens with a chapter by Paul Harrison highlighting the several convergence points among the diverse schizophrenia-related genes. This is followed by chapters reviewing several different specific genes, including Neuregulin, DISC-1, dysbindin, and Homer, among others, and by several chapters presenting information on physiological cortical processes that could be affected by those genes. These include glutamatergic, GABAergic and cholinergic neurotransmission.Current hot topics in schizophrenia research are also highlighted in the book. A concept that is gaining strength in the field, the chapters in this book summarize the current state of affairs in schizophrenia pathophysiology, with a consideration of genetic elements that may contribute to it. Cortical Deficits in Schizophrenia: From Genes to Function will prove a useful tool for those interested in a better understanding of schizophrenia. Even if more predisposing genes (not included in this book) become identified, the work laid out here will prove critical for assigning a functional (or dysfunctional) role to those genes. Although this is a fast-evolving field, the information and concepts covered in this book will likely be useful for years to come.
Coronary Heart Disease in Clinical Practice
The broad coverage of this book includes chapters on all aspects of modern coronary heart disease practice, including cardiac investigations, angina, acute myocardial infarction, heart failure, arrhythmia, lipids, hypertension and diabetes. Aspects of risk modification, including nutrition, obesity, smoking and alcohol, are also outlined. The book contains carefully selected medical questions on hot topics and each is answered at length with the aid of illustrations and tables. It also highlights and summarizes the important aspects of the numerous current international guidelines and trials.
Cooperation in Wireless Networks : Principles and Applications : Real Egoistic Behavior is to Cooperate!
Cooperation in Wireless Networks: Principles and Applications covers the underlying principles of cooperative techniques as well as several applications demonstrating the use of such techniques in practical systems. The work is written in a collaborative manner by several authors from Asia, America, and Europe. Twenty chapters introduce and discuss in detail the main cooperative strategies for the whole communication protocol stack from the application layer down to the physical layer. Furthermore power saving strategies, security, hardware realization, and user scenarios for cooperative communication systems are introduced and discussed. The book also summarizes the strength of cooperation for upcoming generation of wireless communication systems, clearly motivating the use of cooperative techniques and pointing out that cooperation will become one of the key technologies enabling 4G and beyond. This book puts into one volume a comprehensive and technically rich view of the wireless communications scene from a cooperation point of view.
Cooperation in Primates and Humans : Mechanisms and Evolution
Cooperative behavior has been one of the enigmas of evolutionary theory since the days of Darwin. The contributions to this book examine the many facets of cooperative behavior in primates and humans. Some of the world’s leading experts summarize and review the state of the art of theoretical and empirical studies of cooperation. This is the first attempt to bridge the gap between parallel research activities in primatology and studies of humans. This comparative approach highlights both common principles as well as aspects of human uniqueness with respect to cooperative behavior.
