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The aim of this work is to take stock in a clear and didactic way on all the current knowledge on osteoarthritis of the knee and its treatment. It successively addresses the diagnosis and the medical treatment, then the surgical treatments then finally the various aspects of the total knee prosthesis. This book is designed to be read at several levels: basic information is intended particularly for non-specialist or trainee surgeons, rheumatologists, rehabilitation physicians, radiologists and physiotherapists. More specialized aspects are discussed in a second part of the book concerning the future of medical treatment (biology, gene therapy) and certain complex problems of surgical techniques. The points of controversy concerning the total knee replacement are discussed in the last part of the book, of interest to physicians and surgeons.