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Drug delivery systems for cancer therapeutics have revolutionized medicine. De-livery systems have improved the efficacy and reduced the toxicity of current therapiesand resulted in the development of new ones. Today, millions of cancer patients have di-rectly benefited from drug delivery systems, and polymers have been at the frontline ofthese technological advances. Targeted delivery systems of chemotherapeutics to the tu-mour compartment can be achieved systemically, either passively or actively. Polymerconjugation radically changes the pharmacokinetics of the bound drug, and conjugateswith prolonged circulation times target tumours passively via the enhanced permeabil-ity and retention (EPR) effect.