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After the completion of the human genome project, Proteomics is regarded as the 'next frontier.' Not only does Proteomics aim at establishing repertories of all proteins expressed in a cell at a given time and under given physiological or developmental conditions, but more importantly, Proteomics aims at unraveling the complex network of interactions in which proteins are involved in the cell. Techniques have been developed to rapidly create protein-protein interactions maps which in turn can be organized into pathways. Proteins serving as hubs in these networks seem to play crucial biological roles. Some of these proteins may provide new pharmalogical targets for an industry which is rapidly running out of the more classical means of finding new markets. Proteomics and Protein-Protein Interactions: Biology, Chemistry, Bioinformatics, and Drug Design aims at providing a comprehensive yet entertaining view of this rapidly evolving and exciting field. It starts with an overview of the importance of protein-protein interaction in biology (Chapter I). Next, the book dives into Proteomics issues (Chapter II) and describes successful applications of the Proteomics approach. Chapter III focuses on the very specific roles that protein modules play in determining and regulating protein-protein interactions while chapter IV addresses the chemical and energetic underpinnings of such macromolecular interactions. The data generated by a Proteomics approach is abundant and will only be made sense of using bio-informatics: chapter V is dedicated to giving a voice to some of the leaders in the bio-informatics field. Finally, in chapter VI, examples are provided to illustrate the great potential that protein-protein interfaces have as targets for pharmaceutical