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This is a book about interdisciplinary public health reasoning and epidemic m- th elling, in general, and the study of the infamous 14 century AD Black Death d- aster, in particular. We focus on the intellectual context in which epidemic mod- ling takes place, in a way that accounts for the present-day interdisciplinary and multicultural trends in scientific inquiry. Like most scientific fields, public health research defines itself based on knowledge, which raises serious epistemic and cognitive issues.