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Chamomile is one of the most widely used herbs in Western countries, in the present study, we assessed the effect of chamomile combined with insulin on the learning and memory impairments (Alzheimer's disease) induced by scopolamine. The cognition-enhancing effect of chamomile & insulin was investigated using the Y-maze test. Drug-induced amnesia was induced by treating animals with scopolamine. Mix solution administration intranasally reversed scopolamine induced cognitive impairments in mice by the Y-maze test. Moreover, results suggest that the combination of both chamomile and insulin may be a useful cognitive impairment treatment, and its beneficial effects are mediated, in part, via inhibitory effects in vivo on the release of several pro-inflammatory mediators and as a co-absorbent.