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Transdermal Drug Delivery System is a medicated way to administer the active ingredient by the skin; the adhesive patch is the major representation of this system. It is placed on the healthy skin to transfer the medication through the dermas then into the bloodstream.” TDDS” historically used since 19th century. In comparison with other formulations, it has many advantages. Meanly avoidance of first pass metabolism. Several types of TDDS are prepared, they differ by the number of layers and components. Some examples have been cited and modern technology, like nanocarrier, is used in TDDS. One of the APIs used in TDDS is Testosterone; this hormone is produced by human body, secreted in stable amount, when it decreases it causes important troubles. We mention that this kind of pharmaceutical form is missed in our country (Syria) so, we studied the possibility to prepare this form in our research lab. And we take the Testosterone as API of our works.