Applied biophysics for drug discovery / Donald Preston Huddler, Edward Zartler
Publication year: 2017
ISBN: 111909948X
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It is a guide to new techniques and approaches to identifying and characterizing small molecules in early drug discovery. Biophysical methods are reasserting their utility in drug discovery and through a combination of the rise of fragment-based drug discovery and an increased focus on more nuanced characterisation of small molecule binding, these methods are playing an increasing role in discovery campaigns.
Subject: Drug Discovery, Thermodynamics of Biomolecular Interactions, Isothermal Titration Calorimetry, Thermodynamic Rules of Thumb, Fragment‐Based Drug Design, Enthalpic Screening, Protein–Protein Interactions, Microscale Thermophoresis in Drug Discovery, Weak Affinity Chromatography, NMR Methods,
