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Electronic prescribing (EP) is a complex discipline, the success of which relies on the successful interplay of system design, data support and clinical practice. It represents the use of electronic systems to facilitate and enhance communication of a prescription or medicine order, and improves legibility and completeness of prescriptions, improves availability of electronic decision support tools at the point of prescribing, enables a comprehensive audit trail, and reduces medication-related errors. These benefits are far-reaching in significance, both in terms of their effects on risk management and risk reduction and their financial impact. Given the likely growth of interest in electronic medicines management, this discussion of relevant design issues and their impact is timely.