RNA Interference
Publication year: 2008
ISBN: 978-3-540-75157-1
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The use of RNA interference (RNAi) to evoke gene silencing in mammalian cells has almost become routine laboratory practice. Through refinement of double-stranded RNA (dsRNA) triggers of RNAi and creation of genome-scale libraries, the first genome-wide loss of function screens have been carried out in mammals. This review discusses some of the key features of RNAi in mammalian systems.
Subject: Biomedical and Life Sciences, RNA, RNAi pathway, biochemistry, cell, chemistry, chromatin, gene, genetics, mammalian oocytes, metabolism, microRNA, plants, polymer, transcription, yeast
