Book Details

Internet Resource: Please Login to download book

Tumor Induced Immune Suppression: Mechanisms and Therapeutic Reversal focuses on the critical question of tumor biology: "Why can tumors escape immune system control?" It also addresses one of the most important problems within the field of clinical oncology: the lack of efficient cancer vaccines. Edited by Dmitry Gabrilovich and Andy Hurwitz, the book is the first attempt at a systematic and comprehensive analysis of the various immunosuppressive mechanisms in cancer. This analysis includes information on: Different surface molecules that mediate T-cell suppression in cancer; The specific roles of dendritic cells, macrophages, and myeloid-derived suppressor cells in tumor non-responsiveness; The contribution of regulatory T cells in the inability of immune systems to mount antitumor response; The role of T-cell signaling and different metabolic pathways in tumor-associated immune suppression.