Book Details

Structure-based Drug Discovery

Publication year: 2007

ISBN: 978-1-4020-4407-6

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Structure-based drug discovery describes the latest developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being used worldwide. The use of 3-D protein structures in new, Fragment-based, approaches to drug discovery are described in some detail. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions. In addition, developments in computational chemistry methodology are covered together with an assessment of practical applications.


Subject: Chemistry and Materials Science, Computational chemistry, Drug discovery, Fragment - based, NMR, Protein structure, Structural genomics, X-ray crystallography, biology, chemistry