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ICARIS 2006 is the ?fth instance of a series of conferences dedicated to the comprehension and the exploitation of immunological principles through their translation into computational terms.Their axis of research tries to stabilize an on-going identity somewhere in the crossroad of engineering (building useful artifacts), natural sciences (biologyor psychology— improving the comprehension and prediction of natural phenomena) and t- oretical computer sciences (developing and mastering the algorithmic world). Accordingly and depending on which of these perspectives receives more s- port, they attempt at attracting di?erent kinds of scientists and at stimul- ing di?erent kinds of scienti?c attitudes. For many years and in the previous ICARIS conferences, it was clearly the “engineering.