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This book contains up-to-date reviews on different aspects of the ubiquitin proteasome system and its involvement in several neurodegenerative diseases. It is an indispensable source of information for scientists studying neurodegeneration. The book provides information on the basics of the ubiquitin proteasome system, but mainly describes a number of aspects of involvement of this system in neurodegeneration. All major hypotheses on the possible causes of neurodegeneration, such as oxidative stress, inflammation, and aging, are discussed in view of their effect on the ubiquitin proteasome system.