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Biofilm is a complex structure of microbiome having bacterial colonies adhere to the surface. These cells are embedded in extracellular polymeric substances, a matrix generally composed of eDNA, proteins and polysaccharides, showing high resistance to antibiotics. Quorum sensing plays an important role in regulating the biofilm formation. Biofilm is one of the major causes of infection persistence especially in nosocomial settings through indwelling devices. There are many approaches being used to control biofilm. Indeed, the adhesive characteristics of natural human flora are now considered as a tool for preventing the adhesion of pathogenic bacteria to avert infection. These antibiofilm approaches represent a promising therapeutic target in the treatment of biofilm infections and development of a strong capability to interfere with different phases of the biofilm development.