Drug discovery and GBCR – Related CNS Disorders / Anas Shabakji ; Sarah Joudieh ; Ruba Abou Assali
Publication year: 2019
ISBN: Ph00025
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Neurodegenerative diseases are a large group of neurological disorders with diverse etiological and pathological phenomena. However, current therapeutics rely mostly on symptomatic relief while failing to target the underlying disease pathobiology. G-protein-coupled receptors (GPCRs) are one of the most frequently targeted receptors for developing novel therapeutics for central nervous system (CNS) disorders. Many currently available antipsychotic therapeutics also act as either antagonists or agonists of different GPCRs. Therefore, GPCR-based drug development is spreading widely to regulate neurodegeneration and associated cognitive deficits through the modulation of canonical and noncanonical signals.
Subject: Drug development, Drugs Design, Drugs Research, Drug Discovery, Pharmaceutical chemistry, Neurological disorders, Nervous System Diseases, G Protein Coupled Receptor, Chemicals and Drugs Category, Proteins
