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General principle was developed for the selection of subjects for Pharmacogenetics investigations. Depending on the particular metabolic pathway involved, studies may require that subjects be under carefully controlled, homogeneous environmental condition. Otherwise, segregation in families of some genetically transmitted traits can be concealed by effect from multiple hos factors. Therefore; in some Pharmacogenetics studies of pharmacokinetic variations, differences among subjects with respect to critical host factors can profoundly influence the results obtained and conclusions drawn.