Book Details


Applied biophysics for drug discovery / Donald Preston Huddler, Edward Zartler

Publication year: 2017

ISBN: 111909948X

Internet Resource: Please Login to download book

It is a guide to new techniques and approaches to identifying and characterizing small molecules in early drug discovery. Biophysical methods are reasserting their utility in drug discovery and through a combination of the rise of fragment-based drug discovery and an increased focus on more nuanced characterisation of small molecule binding, these methods are playing an increasing role in discovery campaigns.

Subject: Drug Discovery, Thermodynamics of Biomolecular Interactions, Isothermal Titration Calorimetry, Thermodynamic Rules of Thumb, Fragment‐Based Drug Design, Enthalpic Screening, Protein–Protein Interactions, Microscale Thermophoresis in Drug Discovery, Weak Affinity Chromatography, NMR Methods,