Book Details


Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune-Mediated Inflammatory Diseases / Honghui Zhou, Diane R. Mould

Publication year: 2019

ISBN: 111928919X

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Discuss the pathophysiology of autoimmune diseases in addition to both theoretical and practical aspects of quantitative pharmacology for therapeutic proteins, current translational medicine research methodologies and novel thinking in treatment paradigm strategies for IMIDs. Other notable features include: Contributions from well-known authors representing leading academic research centers, specialized contract research organizations and pharmaceutical industries whose pipelines include therapeutic proteins Chapters on a wide range of topics (e.g., pathophysiology of autoimmune diseases, biomarkers in ulcerative colitis, model-based meta-analysis use in the development of therapeutic proteins) Case studies of applying quantitative pharmacology approaches to guiding therapeutic protein drug development in IMIDs such as psoriasis, inflammatory bowel disease, multiple sclerosis and lupus

Subject: Pharmacology, Immunologic diseases, Immunologic diseases-Treatment, Mathematical models, Pharmaceutical chemistry, Medicinal Chemistry, Drug Discovery, Drug Development, Quantitative Pharmacology, Pharmacometrics, Pharmacokinetics