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One of the most intriguing questions facing modern science is the inner workings of the human brain. Functional magnetic resonance imaging (fMRI) is a powerful tool used to study the human brain in action. The data produced from mapping the active processes within the brain present many challenges to statisticians, computer scientists, engineers and other data analysts, due to their complex structure and the ever-increasing sophistication of the scientific questions being posed by researchers. This book represents the first in-depth discussion of statistical methodology, which it couples with an introduction to the scientific background needed to understand the data.