Diverse Roles of Integrin Receptors in Articular Cartilage
Publication year: 2008
ISBN: 978-3-540-78771-6
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Recent studies from the authors' laboratory and from other leading groups have shown that ß1-integrins are essential for cell signalling and communication in chondrocytes. Furthermore, ß1-integrins function as mechanoreceptors in the chondrocyte mechanotransduction pathway. Their expression is therefore essential for maintaining the chondrocyte phenotype, preventing chondrocyte apoptosis and regulating chondrocyte-specific gene expression. This book volume summarizes the work that the authors have done on ß1-integrins over the last 18 years and focuses on the expression and regulation of these proteins in chondrocytes and their role in the context of the unique function of chondrocytes within articular cartilage.
Subject: Biomedical and Life Sciences, ageing cartilage, articular cartilage, cartilage, cells, chondrocyte, chondrogenesis, collagen types I, II, cytoskeletal proteins, extracellular matrix proteins, mesenchymal limb bud cells, osteoarthritis, proinflammatory cytokines, tissue
