Book Details

978-1-4020-6300-8

Problems of High Altitude Medicine and Biology

Publication year: 2007

ISBN: 978-1-4020-6300-8

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The major characteristic pathological findings of pulmonary vascular remodelling are increased wall thickening of pulmonary vessels and mus- larization of small arteries. In laboratory animals, decreased ambient oxygen concentrations cause similar pathological findings, including pulmonary smooth muscle hypertrophy and proliferation [22,23]. It has been suggested that proliferation of pulmonary arterial smooth muscle cells (PASMC) is a key component of pulmonary vascular remodelling, and several in vitro studies have also addressed that exposure to hypoxia can stimulate prolife- tion of PASMC [13,4,1]. The proliferation of the PASMC begins when the cells enter into the cell cycle.


Subject: Mathematics and Statistics, Atmen, Biology, Chemistry, NATO, Radiologieinformationssystem, Science, Security, Sub-Series A, hypertension