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The purpose of this book is to discuss whether statistical methods make sense. That is a fair question, at the heart of the statistician-client relationship, but put so boldly it may arouse anger. The many books entitled something like Foundations of Statistics avoid controversy by merely describing the various methods without explaining why certain conclusions may be drawn from certain data. But we statisticians need a better answer then just shouting a little louder. To avoid a duel, we prejudge the issue and ask the narrower question: "In what sense do statistical methods provide scientific evidence.