Telomeres and Telomerase in Ageing, Disease, and Cancer
Publication year: 2008
ISBN: 978-3-540-73709-4
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A special focus of the book is on adult stem cells. There is emerging evidence that adult stem cell ageing impairs organismal fitness and survival and contributes to cancer formation (cancer stem cells). The book summarizes basic mechanisms of adult stem cell ageing. Moreover, the authors describe evidence that telomere dysfunction impairs stem cell function by inducing cell intrinsic checkpoints as well as environmental alterations.
Subject: Biomedical and Life Sciences, Ageing, DNA, Telomere, aging, apoptosis, cancer, cell, cell lines, development, influence, molecular mechanisms, proliferation, senescence, stem cell, stem cells
