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The impact of papillomavirus (HPV) infection is considerable. More than one in two women has been exposed to HPV in her lifetime and around 10% will develop a chronic infection. Of these, 20% will develop cervical cancer in the absence or failure of screening. In France, high-risk HPV infection causes 80,000 precancerous lesions, 3,400 cervical cancers and the death of 1,000 women every year. Smear screening performed at a regular rate and according to quality standards has resulted in a significant decrease in incidence and mortality over the past 20 years. However, despite this considerable success, the so-called preventable disease has not been eradicated; testing is a complex process that only benefits part of the population while those who benefit endure its weaknesses. Optimization of screening and treatment is now made possible by the use of innovative techniques including the smear in liquid suspension, the HPV test, and soon viral genotyping and molecular markers guaranteeing maximum protection. Because cervical cancer is the result of chronic HPV infection, we already have the extraordinary chance to prevent it with a prophylactic vaccine. This progress will have a major impact on our practices as it happens in a poorly prepared medico-sociological environment. This resolutely practical and educational book provides an overview of knowledge and perspectives on HPV infection and its associated pathologies while deciphering the new challenges and practices in the vaccine era.