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This proceedings volume contains a selection of papers presented at the symposium "International Conference on High Performance Scientific Computing'' held at the Hanoi Institute of Mathematics of the Vietnam National Center for Natural Science and Technology (NCST). The contributions cover the broad interdisciplinary spectrum of scientific computing and present recent advances in theory, development of methods, and applications in practice. Subjects covered are mathematical modelling, numerical simulation, methods for optimization and optimal control, parallel computing, symbolic computing, software development, applications of scientific computing in physics, chemistry, biology and mechanics, environmental and hydrology problems, transport, logistics and site location, communication networks, production scheduling, industrial and commercial problems.