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Edited volumes run the danger of being a hotchpotch of contributions on a wide variety of topics. Here, we have explicitly focused on a central theme in contemporary economic geography and regional science, namely the relationship between learning, innovation and clustering. Internationally renowned scientists made both theoretical and empirical contributions to this volume. We think this book constitutes a broad palette of contemporary thinking and research on the relationship between spatial concentration and innovation and hope it will play a significant role in future debates on this issue.