Organ on a chip for drug development and disease modeling نينار انطون ؛ جويل عساف ؛ كارون كلكيان ؛ صفا نجار ؛ إشراف د. رانيا مطر ؛ أوس السلمان
Publication year: 2022
ISBN: Ph00214
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“Organ-on-a-chip” systems integrate microengineering, microfluidic technologies, and biomimetic principles to create key aspects of living organs faithfully, including critical microarchitecture, spatiotemporal cell–cell interactions, and extracellular microenvironments. This creative platform and its multiorgan integration recapitulating organ-level structures and functions can bring unprecedented benefits to a diversity of applications, such as developing human in vitro models for healthy or diseased organs, enabling the investigation of fundamental mechanisms in disease etiology and organogenesis, benefiting drug development in toxicity screening and target discovery, and potentially serving as replacements for animal testing.
Subject: Drug development, Microfluidics, Organs-on-a-chip, body-on-a-chip, Disease models
