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Gastroesophageal reflux disease (GERD) is a common disease with a high prevalence worldwide and a great socioeconomic burden. GERD is a multifactorial disease in which anatomical and functional factors both play a pathogenetic role. The disease can manifest in various symptoms which can be grouped into typical, atypical and extra-esophageal symptoms. The pathophysiology of GERD is complex and not completely understood. An abnormal LES pressure and increased reflux during transient LES relaxations are believed to be key etiologic factors. Prolonged exposure of the esophagus to acid is another. Heartburn and acid regurgitation are the most common symptoms of GERD, although pathologic reflux can result in a wide variety of clinical presentations.